2. Immunology/Inflammation Anti-infection
  3. COX Interleukin Related Bacterial Fungal Parasite
  4. Lupeol acetate

Lupeol acetate is a derivative of Lupeol. Lupeol acetate is an anti-inflammatory, antibacterial, anti-trypanosomic and anticancer agent with oral activity. Lupeol acetate significantly improves the symptoms of rheumatoid arthritis by down-regulating the expression of inflammatory cytokines and osteoclast production. Lupeol acetate inhibits spermatogenesis in male rats and eventually led to infertility.

For research use only. We do not sell to patients.

Lupeol acetate Chemical Structure

Lupeol acetate Chemical Structure

CAS No. : 1617-68-1

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Based on 1 publication(s) in Google Scholar

Lupeol acetate Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Lupeol acetate

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  • Purity & Documentation

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Description

Lupeol acetate is a derivative of Lupeol. Lupeol acetate is an anti-inflammatory, antibacterial, anti-trypanosomic and anticancer agent with oral activity. Lupeol acetate significantly improves the symptoms of rheumatoid arthritis by down-regulating the expression of inflammatory cytokines and osteoclast production. Lupeol acetate inhibits spermatogenesis in male rats and eventually led to infertility[1][2][3][4].

IC50 & Target

COX-2

 

Cellular Effect
Cell Line Type Value Description References
A549 IC50
29.826 μM
Compound: Compound 9
Cytotoxicity against human A549 cells assessed as cell growth inhibition by MTT assay
Cytotoxicity against human A549 cells assessed as cell growth inhibition by MTT assay
[PMID: 27913179]
B16 IC50
22.7 μM
Compound: 3
Growth inhibition of mouse B16 2F2 cells after 3 days
Growth inhibition of mouse B16 2F2 cells after 3 days
[PMID: 12027734]
B16 ED50
7.5 μM
Compound: 3
Induction of melanogenesis in mouse B16 2F2 cells assessed as intracellular melanin content after 3 days
Induction of melanogenesis in mouse B16 2F2 cells assessed as intracellular melanin content after 3 days
[PMID: 12027734]
Hep 3B2 IC50
18.692 μM
Compound: Compound 9
Cytotoxicity against human Hep3B cells assessed as cell growth inhibition by MTT assay
Cytotoxicity against human Hep3B cells assessed as cell growth inhibition by MTT assay
[PMID: 27913179]
J774.A1 IC50
33.2 μM
Compound: 5
Antiinflammatory activity in mouse J774A1 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS challenge measured after 24 hrs by Griess method
Antiinflammatory activity in mouse J774A1 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS challenge measured after 24 hrs by Griess method
[PMID: 24909081]
RAW264.7 IC50
> 0.4 μM
Compound: lupenyl acetate
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide release after 24 hrs
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide release after 24 hrs
[PMID: 20192236]
RAW264.7 IC50
36.7 μM
Compound: 5
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS challenge measured after 24 hrs by Griess method
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS challenge measured after 24 hrs by Griess method
[PMID: 24909081]
In Vitro

Lupeol acetate (3.125-100mg/mL; 7 days) inhibits the growth of M. phaseolina with a bacteriostatic rate of 79-81%[1].
Lupeol acetate (3-94 µg/mL; 24-48 h) induces death of trypomastigote with an EC50 of 15.82 µg/mL and an inhibition of amastigote stage with an IC50 of 32.55 µg/mL[2].
Lupeol acetate (0-80 μM; 25 h) inhibits the activation and expression of TNF-α and IL-1β in LPS (HY-D1056) -treated RAW 264.7 and BMDMs cells[3].
Lupeol acetate (0-80 μM; 25 h) decreases the migration ability of macrophages by down-regulating the expression of COX-2 and MCP-1 and blocks osteoclast differentiation mediated by RANKL[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lupeol acetate Related Antibodies

Western Blot Analysis[3]

Cell Line: LPS(HY-D1056) treated RAW 264.7 cells
Concentration: 0, 10, 20, 40 and 80 μM
Incubation Time: 25 h
Result: Reduced the levels of COX-2 and MCP-1.
In Vivo

Lupeol acetate (50 mg/kg; Intraperitoneal injection; 21 days) shows improvement in the mouse model of rheumatoid arthritis[3].
Lupeol acetate (10 mg/day; Oral administration; 60 days) plays an anti-fertility role in male rats[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DBA/1J mouse aged 8 weeks old with collagen-induced arthritis[3]
Dosage: 50 mg/kg
Administration: Intraperitoneal injection (i.p.); 21 days
Result: Reduced the incidence of arthritis and relieved symptoms of rheumatoid arthritis.
Significantly decreased clinical score and paw thickness.
Significantly lowered TNF-α and IL-1β levels in serum.
Inhibited inflammatory activity, significantly decreased the accumulation of 18F-FDG in the joints.
Reduced the infiltration of macrophages and bone erosion.
Animal Model: Male albino rats of the Wistar strain aged 3.5-4 months old (170 and 200 g)[4]
Dosage: 10 mg/day
Administration: Oral administration (p.o.); 60 days
Result: Did not cause any significant change in the body weights, but significantly reduced in the weight of reproductive organs, i.e. testes, epididymides, seminal vesicle and ventral prostate.
Significantly declined testicular sperm count, epididymal sperm count and motility, which resulted in reduction of male fertility by 100%.
Interfered with spermatogenesis and significantly reduced most tubule cell types.
Significantly reduced biochemical parameters of tissues i.e. protein, sialic acid, glycogen and cholesterol content of testes and seminal vesicular fructose.
Molecular Weight

468.75

Formula

C32H52O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]([C@@]1(CC[C@@]2([H])C3(C)C)C)(CC4)[C@@](CC[C@]1([H])[C@]2(CC[C@@H]3OC(C)=O)C)([H])[C@]([C@@H]5C(C)=C)([H])[C@@]4(CC5)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : ≥ 2 mg/mL (4.27 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1333 mL 10.6667 mL 21.3333 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

SDS (251 KB)

COA (253 KB) HNMR (270 KB) MS (198 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 2.1333 mL 10.6667 mL 21.3333 mL 53.3333 mL
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Lupeol acetate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lupeol1617-68-1COXInterleukin RelatedBacterialFungalParasiteCyclooxygenaseILmacrophagescytokinesarthritisantibacterial agentanti-trypanosomic agentanti-tumor agentInhibitorinhibitorinhibit

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