Lycoperodine-1 (Synonyms: Cyclomethyltryptophan)

Name: Lycoperodine-1
Brand: MedChemExpress
SKU: HY-121584
Rating: 4.5 (1 reviews)

Cat. No.: HY-121584 Purity: 99.82%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Lycoperodine-1 (Cyclomethyltryptophan) is an active product that can be isolated from tomato fruits (Lycopersicon sculentum). Lycoperodine-1 act as an agonist of Ca²⁺ sensing receptors (CaSR).

For research use only. We do not sell to patients.

Lycoperodine-1 Chemical Structure

CAS No. : 42438-90-4

Size	Price	Stock	Quantity
5 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 75	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 130	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 190	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 270	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
Platelet	IC₅₀	701.01 nM Compound: 1, TCCA	Antiplatelet aggregation activity against ADP-induced pig platelet aggregation after 5 mins by aggregometer Antiplatelet aggregation activity against ADP-induced pig platelet aggregation after 5 mins by aggregometer	[PMID: 20329729]
Platelet	IC₅₀	752.28 nM Compound: 1, TCCA	Antiplatelet aggregation activity against platelet-activating factor-induced pig platelet aggregation after 5 mins by aggregometer Antiplatelet aggregation activity against platelet-activating factor-induced pig platelet aggregation after 5 mins by aggregometer	[PMID: 20329729]
Platelet	IC₅₀	866.14 nM Compound: 1, TCCA	Antiplatelet aggregation activity against arachidonic acid-induced pig platelet aggregation after 5 mins by aggregometer Antiplatelet aggregation activity against arachidonic acid-induced pig platelet aggregation after 5 mins by aggregometer	[PMID: 20329729]
Platelet	IC₅₀	981.52 nM Compound: 1, TCCA	Antiplatelet aggregation activity against thrombin-induced pig platelet aggregation after 5 mins by aggregometer Antiplatelet aggregation activity against thrombin-induced pig platelet aggregation after 5 mins by aggregometer	[PMID: 20329729]

Molecular Weight

216.24

Formula

C₁₂H₁₂N₂O₂

CAS No.

42438-90-4

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@@H]1CC2=C(NC3=C2C=CC=C3)CN1

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 40 mg/mL (184.98 mM; ultrasonic and adjust pH to 9 with 1 M NaOH; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.6245 mL	23.1225 mL	46.2449 mL
5 mM	0.9249 mL	4.6245 mL	9.2490 mL
10 mM	0.4624 mL	2.3122 mL	4.6245 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 4 mg/mL (18.50 mM); Clear solution

This protocol yields a clear solution of ≥ 4 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (40.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 4 mg/mL (18.50 mM); Clear solution

This protocol yields a clear solution of ≥ 4 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (40.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.82%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (252 KB) HNMR (116 KB) RP-HPLC (206 KB)

Handling Instructions (2659 KB)

References

[1]. Shoji Yahara, et al. Steroidal Alkaloid Glycosides from Tomato (Lycopersicon esculentum). J Nat Prod. 2004 Mar;67(3):500-2. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.6245 mL	23.1225 mL	46.2449 mL	115.6123 mL
	5 mM	0.9249 mL	4.6245 mL	9.2490 mL	23.1225 mL
	10 mM	0.4624 mL	2.3122 mL	4.6245 mL	11.5612 mL
	15 mM	0.3083 mL	1.5415 mL	3.0830 mL	7.7075 mL
	20 mM	0.2312 mL	1.1561 mL	2.3122 mL	5.7806 mL
	25 mM	0.1850 mL	0.9249 mL	1.8498 mL	4.6245 mL
	30 mM	0.1541 mL	0.7707 mL	1.5415 mL	3.8537 mL
	40 mM	0.1156 mL	0.5781 mL	1.1561 mL	2.8903 mL
	50 mM	0.0925 mL	0.4624 mL	0.9249 mL	2.3122 mL
	60 mM	0.0771 mL	0.3854 mL	0.7707 mL	1.9269 mL
	80 mM	0.0578 mL	0.2890 mL	0.5781 mL	1.4452 mL
	100 mM	0.0462 mL	0.2312 mL	0.4624 mL	1.1561 mL

Lycoperodine-1 Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lycoperodine-142438-90-4CyclomethyltryptophanLycoperodine1Lycoperodine 1CaSRCalcium-sensing receptortomato fruitsLycopersicon sculentumInhibitorinhibitorinhibit

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Lycoperodine-1 (Synonyms: Cyclomethyltryptophan)

Customer Review

Lycoperodine-1 Related Antibodies

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Biological Activity

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Complete Stock Solution Preparation Table

Lycoperodine-1 Related Classifications

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