2. Metabolic Enzyme/Protease
  3. Epoxide Hydrolase
  4. mEH-IN-1

mEH-IN-1 (Compound 62) is a potent microsomal epoxide hydrolase (mEH) inhibitor with the IC50 of 2.2 nM. The mEH is a mammalian α/β-fold hydrolase enzyme, expressed in almost all tissues, hydrolyzes a wide range of epoxide containing molecules. The mEH is mainly localized in the endoplasmic reticulum (ER) of eukaryotic cells. mEH-IN-1 can be used for the research of preeclampsia, hypercholanemia and cancer.

For research use only. We do not sell to patients.

mEH-IN-1 Chemical Structure

mEH-IN-1 Chemical Structure

CAS No. : 2418576-06-2

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Based on 1 publication(s) in Google Scholar

mEH-IN-1 Related Antibodies

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Description

mEH-IN-1 (Compound 62) is a potent microsomal epoxide hydrolase (mEH) inhibitor with the IC50 of 2.2 nM. The mEH is a mammalian α/β-fold hydrolase enzyme, expressed in almost all tissues, hydrolyzes a wide range of epoxide containing molecules. The mEH is mainly localized in the endoplasmic reticulum (ER) of eukaryotic cells. mEH-IN-1 can be used for the research of preeclampsia, hypercholanemia and cancer[1].

Molecular Weight

385.37

Formula

C16H17F6NOS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC(C(C1CCCC1)SCC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (129.75 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5949 mL 12.9745 mL 25.9491 mL
5 mM 0.5190 mL 2.5949 mL 5.1898 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5949 mL 12.9745 mL 25.9491 mL 64.8727 mL
5 mM 0.5190 mL 2.5949 mL 5.1898 mL 12.9745 mL
10 mM 0.2595 mL 1.2975 mL 2.5949 mL 6.4873 mL
15 mM 0.1730 mL 0.8650 mL 1.7299 mL 4.3248 mL
20 mM 0.1297 mL 0.6487 mL 1.2975 mL 3.2436 mL
25 mM 0.1038 mL 0.5190 mL 1.0380 mL 2.5949 mL
30 mM 0.0865 mL 0.4325 mL 0.8650 mL 2.1624 mL
40 mM 0.0649 mL 0.3244 mL 0.6487 mL 1.6218 mL
50 mM 0.0519 mL 0.2595 mL 0.5190 mL 1.2975 mL
60 mM 0.0432 mL 0.2162 mL 0.4325 mL 1.0812 mL
80 mM 0.0324 mL 0.1622 mL 0.3244 mL 0.8109 mL
100 mM 0.0259 mL 0.1297 mL 0.2595 mL 0.6487 mL
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mEH-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

mEH-IN-12418576-06-2Epoxide HydrolaseMicrosomal Epoxide HydrolasemEH inhibitorendoplasmic reticulumpreeclampsiahypercholanemiacancerInhibitorinhibitorinhibit

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