Metacetamol (Synonyms: AMAP)

Cat. No.: HY-B1309: FAQs
Data Sheet Handling Instructions Technical Support

Metacetamol (AMAP) is a non-hepatotoxic analog of acetaminophen (APAP). Metacetamol increases glutathione (GSH) in PHH and causes mitochondrial damage. Metacetamol increases total JNK in PHH cell .

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Metacetamol Chemical Structure

CAS No. : 621-42-1

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Biological Activity
Purity & Documentation
References
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Description

Metacetamol (AMAP) is a non-hepatotoxic analog of acetaminophen (APAP). Metacetamol increases glutathione (GSH) in PHH and causes mitochondrial damage. Metacetamol increases total JNK in PHH cell ^[1].

Molecular Weight

151.16

Formula

C₈H₉NO₂

CAS No.

621-42-1

Appearance

Solid

SMILES

CC(NC1=CC=CC(O)=C1)=O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (330.78 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.6155 mL	33.0775 mL	66.1551 mL
5 mM	1.3231 mL	6.6155 mL	13.2310 mL
10 mM	0.6616 mL	3.3078 mL	6.6155 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yuchao Xie, et al. Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes. Toxicol Appl Pharmacol. 2015, 289, 2.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	6.6155 mL	33.0775 mL	66.1551 mL	165.3877 mL
	5 mM	1.3231 mL	6.6155 mL	13.2310 mL	33.0775 mL
	10 mM	0.6616 mL	3.3078 mL	6.6155 mL	16.5388 mL
	15 mM	0.4410 mL	2.2052 mL	4.4103 mL	11.0258 mL
	20 mM	0.3308 mL	1.6539 mL	3.3078 mL	8.2694 mL
	25 mM	0.2646 mL	1.3231 mL	2.6462 mL	6.6155 mL
	30 mM	0.2205 mL	1.1026 mL	2.2052 mL	5.5129 mL
	40 mM	0.1654 mL	0.8269 mL	1.6539 mL	4.1347 mL
	50 mM	0.1323 mL	0.6616 mL	1.3231 mL	3.3078 mL
	60 mM	0.1103 mL	0.5513 mL	1.1026 mL	2.7565 mL
	80 mM	0.0827 mL	0.4135 mL	0.8269 mL	2.0673 mL
	100 mM	0.0662 mL	0.3308 mL	0.6616 mL	1.6539 mL

Metacetamol Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Metacetamol621-42-1AMAPJNKReactive Oxygen Speciesc-Jun N-terminal kinaseAPAPglutathione (GSH)PHHmitochondrial damageInhibitorinhibitorinhibit

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