Methyl 2,4,6-trihydroxybenzoate

Name: Methyl 2,4,6-trihydroxybenzoate
Brand: MedChemExpress
SKU: HY-W144096
Rating: 4.5 (1 reviews)

Cat. No.: HY-W144096 Purity: 98.27%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Methyl 2,4,6-trihydroxybenzoate is a metabolite of 2,4,6-trihydroxybenzoate and exhibits properties as an antioxidant, lipid lowering and anticancer activities.

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Methyl 2,4,6-trihydroxybenzoate Chemical Structure

CAS No. : 3147-39-5

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Free Sample (0.1 - 0.5 mg)		Apply Now
100 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
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1 g		Get quote

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Based on 1 publication(s) in Google Scholar

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Purity & Documentation
References
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Description

Methyl 2,4,6-trihydroxybenzoate is a metabolite of 2,4,6-trihydroxybenzoate and exhibits properties as an antioxidant, lipid lowering and anticancer activities^[1].

Molecular Weight

184.15

Formula

C₈H₈O₅

CAS No.

3147-39-5

Appearance

Solid

Color

White to off-white

SMILES

COC(=O)C1=C(C=C(C=C1O)O)O

Structure Classification

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (543.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.4304 mL	27.1518 mL	54.3036 mL
5 mM	1.0861 mL	5.4304 mL	10.8607 mL
10 mM	0.5430 mL	2.7152 mL	5.4304 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (13.58 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (13.58 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (13.58 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.27%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (249 KB) HNMR (223 KB) LCMS (259 KB)

Handling Instructions (2659 KB)

References

[1]. Ishita Chatterjee, et al. Vitamin D receptor promotes healthy microbial metabolites and microbiome. Sci Rep. 2020 Apr 30;10(1):7340. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.4304 mL	27.1518 mL	54.3036 mL	135.7589 mL
	5 mM	1.0861 mL	5.4304 mL	10.8607 mL	27.1518 mL
	10 mM	0.5430 mL	2.7152 mL	5.4304 mL	13.5759 mL
	15 mM	0.3620 mL	1.8101 mL	3.6202 mL	9.0506 mL
	20 mM	0.2715 mL	1.3576 mL	2.7152 mL	6.7879 mL
	25 mM	0.2172 mL	1.0861 mL	2.1721 mL	5.4304 mL
	30 mM	0.1810 mL	0.9051 mL	1.8101 mL	4.5253 mL
	40 mM	0.1358 mL	0.6788 mL	1.3576 mL	3.3940 mL
	50 mM	0.1086 mL	0.5430 mL	1.0861 mL	2.7152 mL
	60 mM	0.0905 mL	0.4525 mL	0.9051 mL	2.2626 mL
	80 mM	0.0679 mL	0.3394 mL	0.6788 mL	1.6970 mL
	100 mM	0.0543 mL	0.2715 mL	0.5430 mL	1.3576 mL