2. PROTAC Immunology/Inflammation
  3. PROTACs IKZF Family
  4. MG degrader 1

MG degrader 1 (Compd E14) is a PROTAC degrader of IKZF3, GSPT1, and GSPT2 with an EC50 value of 1.385 nM in MM.1S cells.

For research use only. We do not sell to patients.

MG degrader 1 Chemical Structure

MG degrader 1 Chemical Structure

Size Price Stock Quantity
5 mg USD 294 In-stock
10 mg USD 469 In-stock
25 mg USD 938 In-stock
50 mg USD 1500 In-stock
100 mg USD 2400 In-stock
200 mg   Get quote  
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Customer Review

Based on 1 publication(s) in Google Scholar

MG degrader 1 Related Antibodies

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IKZF1 IKZF3

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MG degrader 1 (Compd E14) is a PROTAC degrader of IKZF3, GSPT1, and GSPT2 with an EC50 value of 1.385 nM in MM.1S cells[1].

IC50 & Target[1]

IKZF3

1.385 nM (EC50)

Molecular Weight

591.65

Formula

C31H37N5O7
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1N(C2CCC(NC2=O)=O)C(C3=C(NCCCCNC(C(C4=CC=CC(OC)=C4)N(CC(C)C)C=O)=O)C=CC=C31)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (211.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6902 mL 8.4509 mL 16.9019 mL
5 mM 0.3380 mL 1.6902 mL 3.3804 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6902 mL 8.4509 mL 16.9019 mL 42.2547 mL
5 mM 0.3380 mL 1.6902 mL 3.3804 mL 8.4509 mL
10 mM 0.1690 mL 0.8451 mL 1.6902 mL 4.2255 mL
15 mM 0.1127 mL 0.5634 mL 1.1268 mL 2.8170 mL
20 mM 0.0845 mL 0.4225 mL 0.8451 mL 2.1127 mL
25 mM 0.0676 mL 0.3380 mL 0.6761 mL 1.6902 mL
30 mM 0.0563 mL 0.2817 mL 0.5634 mL 1.4085 mL
40 mM 0.0423 mL 0.2113 mL 0.4225 mL 1.0564 mL
50 mM 0.0338 mL 0.1690 mL 0.3380 mL 0.8451 mL
60 mM 0.0282 mL 0.1408 mL 0.2817 mL 0.7042 mL
80 mM 0.0211 mL 0.1056 mL 0.2113 mL 0.5282 mL
100 mM 0.0169 mL 0.0845 mL 0.1690 mL 0.4225 mL
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MG degrader 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MG degrader 1MG degrader1MG degrader-1PROTACsIKZF FamilyInhibitorinhibitorinhibit

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