ML-7

Cat. No.: HY-119038: FAQs
Data Sheet Handling Instructions

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ML-7 is a myosin light chain kinase inhibitor with the activity to inhibit superoxide anion (O(2)(-)) release in human neutrophils. ML-7 can affect the activity of neutrophils independently of myosin light chain kinase. ML-7 inhibits the extracellular O(2)(-) release of stimulated cells, but has no effect on the intracellular O(2)(-) production. ML-7 also strongly inhibits the binding of the intracellular compartment of oxide production to the cell membrane, indicating that it plays a key role in stimulated neutrophils. At the same time, ML-7 protects cardiac function from ischemia/reperfusion injury.

For research use only. We do not sell to patients.

ML-7 Chemical Structure

CAS No. : 109376-83-2

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Other In-stock Forms of ML-7:

ML-7 hydrochloride

Other Forms of ML-7:

ML-7 hydrochloride In-stock

21 Publications Citing Use of MCE ML-7

: ML-7 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2023 Mar 27.; ML-7 hydrochloride (ML-7; 10 μM; 2 h; pretreatment) significantly reduces the protein level of phosphorylated MLC2 and the phosphorylation ratio of MLC2 in BMECs.

: ML-7 purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2021 Mar 22. [Abstract]; Relative protein expression of ZO-1 pretreated with 10 μmol/L ML7 for 1 h. ML7 directly inhibits the expression of ZO-1.

: ML-7 purchased from MedChemExpress. Usage Cited in: Toxicol Lett. 2020 Oct 10;332:146-154. [Abstract]; Cells are incubated with 10 μM ML-7 for 1 h, followed by incubation with 1.0 μM As2O3 for 24 h and assessment of occludin protein expression with Western blotting.

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Description	ML-7 is a myosin light chain kinase inhibitor with the activity to inhibit superoxide anion (O(2)(-)) release in human neutrophils. ML-7 can affect the activity of neutrophils independently of myosin light chain kinase. ML-7 inhibits the extracellular O(2)(-) release of stimulated cells, but has no effect on the intracellular O(2)(-) production. ML-7 also strongly inhibits the binding of the intracellular compartment of oxide production to the cell membrane, indicating that it plays a key role in stimulated neutrophils. At the same time, ML-7 protects cardiac function from ischemia/reperfusion injury^[1].
Molecular Weight	416.28
Formula	C₁₅H₁₇IN₂O₂S
CAS No.	109376-83-2
SMILES	O=S(N1CCNCCC1)(C2=C3C=CC=C(C3=CC=C2)I)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (268 KB) Handling Instructions (2659 KB)
References	[1]. ML-7 inhibits exocytosis of superoxide-producing intracellular compartments in human neutrophils stimulated with phorbol myristate acetate in a myosin light chain kinase-independent manner [Content Brief]

ML-7 Related Classifications

Cardiovascular Disease

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ML-7109376-83-2ML7ML 7Endogenous MetaboliteInhibitorinhibitorinhibit

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ML-7

Other Forms of ML-7:

ML-7 Related Antibodies

21 Publications Citing Use of MCE ML-7

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