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ML-7 is a myosin light chain kinase inhibitor with the activity to inhibit superoxide anion (O(2)(-)) release in human neutrophils. ML-7 can affect the activity of neutrophils independently of myosin light chain kinase. ML-7 inhibits the extracellular O(2)(-) release of stimulated cells, but has no effect on the intracellular O(2)(-) production. ML-7 also strongly inhibits the binding of the intracellular compartment of oxide production to the cell membrane, indicating that it plays a key role in stimulated neutrophils. At the same time, ML-7 protects cardiac function from ischemia/reperfusion injury.

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ML-7 Chemical Structure

ML-7 Chemical Structure

CAS No. : 109376-83-2

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ML-7 Related Antibodies

Top Publications Citing Use of Products

    ML-7 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2023 Mar 27.

    ML-7 hydrochloride (ML-7; 10 μM; 2 h; pretreatment) significantly reduces the protein level of phosphorylated MLC2 and the phosphorylation ratio of MLC2 in BMECs.

    ML-7 purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2021 Mar 22.  [Abstract]

    Relative protein expression of ZO-1 pretreated with 10 μmol/L ML7 for 1 h. ML7 directly inhibits the expression of ZO-1.

    ML-7 purchased from MedChemExpress. Usage Cited in: Toxicol Lett. 2020 Oct 10;332:146-154.  [Abstract]

    Cells are incubated with 10 μM ML-7 for 1 h, followed by incubation with 1.0 μM As2O3 for 24 h and assessment of occludin protein expression with Western blotting.

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    Description

    ML-7 is a myosin light chain kinase inhibitor with the activity to inhibit superoxide anion (O(2)(-)) release in human neutrophils. ML-7 can affect the activity of neutrophils independently of myosin light chain kinase. ML-7 inhibits the extracellular O(2)(-) release of stimulated cells, but has no effect on the intracellular O(2)(-) production. ML-7 also strongly inhibits the binding of the intracellular compartment of oxide production to the cell membrane, indicating that it plays a key role in stimulated neutrophils. At the same time, ML-7 protects cardiac function from ischemia/reperfusion injury[1].

    Molecular Weight

    416.28

    Formula

    C15H17IN2O2S
    CAS No.
    SMILES

    O=S(N1CCNCCC1)(C2=C3C=CC=C(C3=CC=C2)I)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    ML-7 Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    ML-7109376-83-2ML7ML 7OthersInhibitorinhibitorinhibit

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