2. Metabolic Enzyme/Protease
  3. HIF/HIF Prolyl-Hydroxylase
  4. myo-Inositol trispyrophosphate hexasodium

myo-Inositol trispyrophosphate hexasodium  (Synonyms: ITPP hexasodium)

Cat. No.: HY-141510 Purity: ≥98.0%
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myo-Inositol trispyrophosphate (ITPP) hexasodium is a salt form of inositol triphosphate (ITPP). myo-Inositol trispyrophosphate (ITPP) hexasodium is a membrane-permeant hemoglobin allosteric regulator. myo-Inositol trispyrophosphate (ITPP) hexasodium enhances the oxygen release capacity of red blood cells by reducing the affinity of hemoglobin to oxygen. myo-Inositol trispyrophosphate (ITPP) hexasodium can be used in the study of cardiovascular disease and cancer.

For research use only. We do not sell to patients.

myo-Inositol trispyrophosphate hexasodium Chemical Structure

myo-Inositol trispyrophosphate hexasodium Chemical Structure

CAS No. : 23103-35-7

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Based on 1 publication(s) in Google Scholar

Other Forms of myo-Inositol trispyrophosphate hexasodium:

myo-Inositol trispyrophosphate hexasodium Related Antibodies

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Description

myo-Inositol trispyrophosphate (ITPP) hexasodium is a salt form of inositol triphosphate (ITPP). myo-Inositol trispyrophosphate (ITPP) hexasodium is a membrane-permeant hemoglobin allosteric regulator. myo-Inositol trispyrophosphate (ITPP) hexasodium enhances the oxygen release capacity of red blood cells by reducing the affinity of hemoglobin to oxygen. myo-Inositol trispyrophosphate (ITPP) hexasodium can be used in the study of cardiovascular disease and cancer[1][2][3].

In Vitro

Non-salt dose:
myo-Inositol trispyrophosphate (78 mM; 1 h) significantly reduces hypoxia-induced HIF-1α expression in red blood cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

myo-Inositol trispyrophosphate hexasodium Related Antibodies
In Vivo

Non-salt dose:
myo-Inositol trispyrophosphate (1.5 g/kg; intraperitoneal injection; twice a week for 4 weeks) has a protective effect in rat model of myocardial infarction[1].
myo-Inositol trispyrophosphate (1.5 g/kg; intravenous injection; once a week for 11 weeks) has antitumor activity in a rat model of pancreatic cancer[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (280-320 g) with myocardial infarction[1]
Dosage: 1.5 g/kg (Non-salt dose)
Administration: Intraperitoneal injection (i.p.); twice a week for 4 weeks
Result: Essentially halted the increase of LV dilation and significantly reduced impairment of LV ejection fraction, while it had no effect on sham-operated rats.
Animal Model: DSL-6A/C1 tumors treated immunocompetent male Lewis rats[2]
Dosage: 1.5 g/kg (Non-salt dose)
Administration: Intravenous injection (i.v.); once a week for 11 weeks
Result: Significantly extended the survival time of rats.
Basically did not cause liver metastasis and primary tumor growth was restricted to 2 cm3.
Restored the pO2 pressure in tumors reducing hypoxia-inducible and proangiogenic factors.
Molecular Weight

737.88

Formula

C6H6Na6O21P6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=P1(O[C@]2([H])[C@@]3([H])[C@@](OP(OP(O3)(O[Na])=O)(O[Na])=O)([H])[C@]4([H])[C@@](OP(OP(O4)(O[Na])=O)(O[Na])=O)([H])[C@@]2([H])OP(O1)(O[Na])=O)O[Na]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (33.88 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3552 mL 6.7762 mL 13.5523 mL
5 mM 0.2710 mL 1.3552 mL 2.7105 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

SDS (252 KB)

COA (271 KB) HNMR (282 KB) CNMR (191 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.3552 mL 6.7762 mL 13.5523 mL 33.8808 mL
5 mM 0.2710 mL 1.3552 mL 2.7105 mL 6.7762 mL
10 mM 0.1355 mL 0.6776 mL 1.3552 mL 3.3881 mL
15 mM 0.0903 mL 0.4517 mL 0.9035 mL 2.2587 mL
20 mM 0.0678 mL 0.3388 mL 0.6776 mL 1.6940 mL
25 mM 0.0542 mL 0.2710 mL 0.5421 mL 1.3552 mL
30 mM 0.0452 mL 0.2259 mL 0.4517 mL 1.1294 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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myo-Inositol trispyrophosphate hexasodium Related Classifications

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Keywords:

myo-Inositol trispyrophosphate hexasodium23103-35-7ITPP hexasodiumHIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHred blood cellsmyocardial infarction modelpancreatic cancer modelInhibitorinhibitorinhibit

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