2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. Myosmine

Myosmine, a specific tobacco alkaloid in nuts and nut products, has low affinity for a4b2 nicotinic acetylcholinergic receptors (nAChR) with a Ki of 3300 nM.

For research use only. We do not sell to patients.

Myosmine Chemical Structure

Myosmine Chemical Structure

CAS No. : 532-12-7

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Other Forms of Myosmine:

Myosmine Related Antibodies

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Description

Myosmine, a specific tobacco alkaloid in nuts and nut products, has low affinity for a4b2 nicotinic acetylcholinergic receptors (nAChR) with a Ki of 3300 nM[1][2].

IC50 & Target

Ki: 3300 nM (a4b2 nAChR) and >10 µM (AT1)[1]
In Vitro

Myosmine is easily nitrosated, yielding 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB) and the esophageal tobacco carcinogen N'-nitrosonornicotine[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Myosmine Related Antibodies
In Vivo

Myosmine (0.001, 0.005, 0.5, and 50 micromol/kg; oral; in Wistar rats) causes a higher percentage of the radioactivity excreted in urine (86.2% and 88.9%) at the two lower doses (0.001 and 0.005 micromol/kg),as compared with the higher doses (0.5 and 50 micromol/kg), where only 77.8% and 75.4% of the dose is found in urine[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

146.19

Formula

C9H10N2
CAS No.
Appearance

<42°C Solid,>44°C Liquid

Color

Off-white to yellow

SMILES

C1(C2=CC=CN=C2)=NCCC1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (684.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 100 mg/mL (684.04 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.8404 mL 34.2021 mL 68.4041 mL
5 mM 1.3681 mL 6.8404 mL 13.6808 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.95%

COA (250 KB) HNMR (119 KB) GC (191 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 6.8404 mL 34.2021 mL 68.4041 mL 171.0103 mL
5 mM 1.3681 mL 6.8404 mL 13.6808 mL 34.2021 mL
10 mM 0.6840 mL 3.4202 mL 6.8404 mL 17.1010 mL
15 mM 0.4560 mL 2.2801 mL 4.5603 mL 11.4007 mL
20 mM 0.3420 mL 1.7101 mL 3.4202 mL 8.5505 mL
25 mM 0.2736 mL 1.3681 mL 2.7362 mL 6.8404 mL
30 mM 0.2280 mL 1.1401 mL 2.2801 mL 5.7003 mL
40 mM 0.1710 mL 0.8551 mL 1.7101 mL 4.2753 mL
50 mM 0.1368 mL 0.6840 mL 1.3681 mL 3.4202 mL
60 mM 0.1140 mL 0.5700 mL 1.1401 mL 2.8502 mL
80 mM 0.0855 mL 0.4275 mL 0.8551 mL 2.1376 mL
100 mM 0.0684 mL 0.3420 mL 0.6840 mL 1.7101 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Myosmine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Myosmine532-12-7nAChRNicotinic acetylcholine receptorstobaccoalkaloida4b2nicotinicacetylcholinergicreceptorsInhibitorinhibitorinhibit

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