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N,N-Dipropyldopamine hydrobromide 

Cat. No.: HY-132219 Purity: 98.22%
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N. N-dipropyrldopamine is a potent inhibitor of glutamate release and has anticancer activity. The increase of glutamate secretion leads to cancer-induced bone pain (CIBP). N. N-dipropyrldopamine plays an analgesic role in CIBP.

For research use only. We do not sell to patients.

N,N-Dipropyldopamine hydrobromide Chemical Structure

N,N-Dipropyldopamine hydrobromide Chemical Structure

CAS No. : 65273-66-7

Size Price Stock Quantity
1 mg USD 70 In-stock
5 mg USD 210 In-stock
10 mg USD 340 In-stock
25 mg USD 680 In-stock
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Based on 1 publication(s) in Google Scholar

N,N-Dipropyldopamine hydrobromide Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

N. N-dipropyrldopamine is a potent inhibitor of glutamate release and has anticancer activity. The increase of glutamate secretion leads to cancer-induced bone pain (CIBP). N. N-dipropyrldopamine plays an analgesic role in CIBP[1].

IC50 & Target

cystine/glutamate transporter (XC-)[1] IC50:25.45 μM (cystine/glutamate transporter, XC-)[1]
In Vitro

N,N-dipropyldopamine (10-200 μM, 48 h) inhibits cancer cells growth of MDA-MB-231, MCF-7 and Mat-Ly-Lu, with IC50 values of 25.45, 26.3, 28.45 μM, respectively [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N,N-Dipropyldopamine hydrobromide Related Antibodies

Cell Viability Assay[1]

Cell Line: MDA-MB-231, MCF-7 and Mat-Ly-Lu
Concentration: 0-200 μM
Incubation Time: 48 h
Result: Inhibited cell growth with IC50 values of 25.45 μM (MDA-MB-231), 26.3 μM (MCF-7), 28.45 μM (Mat-Ly-Lu).
Molecular Weight

318.25

Formula

C14H24BrNO2
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

OC1=CC=C(CCN(CCC)CCC)C=C1O.[H]Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (314.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1422 mL 15.7109 mL 31.4218 mL
5 mM 0.6284 mL 3.1422 mL 6.2844 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (7.86 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (7.86 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1422 mL 15.7109 mL 31.4218 mL 78.5546 mL
5 mM 0.6284 mL 3.1422 mL 6.2844 mL 15.7109 mL
10 mM 0.3142 mL 1.5711 mL 3.1422 mL 7.8555 mL
15 mM 0.2095 mL 1.0474 mL 2.0948 mL 5.2370 mL
20 mM 0.1571 mL 0.7855 mL 1.5711 mL 3.9277 mL
25 mM 0.1257 mL 0.6284 mL 1.2569 mL 3.1422 mL
30 mM 0.1047 mL 0.5237 mL 1.0474 mL 2.6185 mL
40 mM 0.0786 mL 0.3928 mL 0.7855 mL 1.9639 mL
50 mM 0.0628 mL 0.3142 mL 0.6284 mL 1.5711 mL
60 mM 0.0524 mL 0.2618 mL 0.5237 mL 1.3092 mL
80 mM 0.0393 mL 0.1964 mL 0.3928 mL 0.9819 mL
100 mM 0.0314 mL 0.1571 mL 0.3142 mL 0.7855 mL
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N,N-Dipropyldopamine hydrobromide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N,N-Dipropyldopamine65273-66-7OthersMDA-MB-231MCF-7Mat-Ly-LuCIBPanalgesiaInhibitorinhibitorinhibit

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