2. Epigenetics
  3. Epigenetic Reader Domain
  4. Naphthol AS-MX phosphate

Naphthol AS-MX phosphate  (Synonyms: NASTRp)

Cat. No.: HY-104067 Purity: 99.50%
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Naphthol AS-MX phosphate (NASTRp) is a small molecule inhibitor of the CREB (cyclic adenosine phosphate reaction element binding protein)-CBP (CREB binding protein) transcription factor complex. Naphthol AS-MX phosphate shows antitumor activity against lung cancer cells, inhibiting tumor cell proliferation (IC50=3.701 μmol/L), colony formation, and anchored independent growth in soft AGAR. Naphthol AS-MX phosphate can be used in the study of KRAS mutated lung cancer, especially for KRAS mutated lung cancer with poor chemotherapy resistance and prognosis.

For research use only. We do not sell to patients.

Naphthol AS-MX phosphate Chemical Structure

Naphthol AS-MX phosphate Chemical Structure

CAS No. : 1596-56-1

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50 mg USD 62 In-stock
100 mg USD 99 In-stock
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Description

Naphthol AS-MX phosphate (NASTRp) is a small molecule inhibitor of the CREB (cyclic adenosine phosphate reaction element binding protein)-CBP (CREB binding protein) transcription factor complex. Naphthol AS-MX phosphate shows antitumor activity against lung cancer cells, inhibiting tumor cell proliferation (IC50=3.701 μmol/L), colony formation, and anchored independent growth in soft AGAR. Naphthol AS-MX phosphate can be used in the study of KRAS mutated lung cancer, especially for KRAS mutated lung cancer with poor chemotherapy resistance and prognosis[1].

Molecular Weight

371.32

Formula

C19H18NO5P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C(OP(O)(O)=O)C=C2C=CC=CC2=C1)NC3=CC=C(C)C=C3C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (336.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6931 mL 13.4655 mL 26.9309 mL
5 mM 0.5386 mL 2.6931 mL 5.3862 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6931 mL 13.4655 mL 26.9309 mL 67.3274 mL
5 mM 0.5386 mL 2.6931 mL 5.3862 mL 13.4655 mL
10 mM 0.2693 mL 1.3465 mL 2.6931 mL 6.7327 mL
15 mM 0.1795 mL 0.8977 mL 1.7954 mL 4.4885 mL
20 mM 0.1347 mL 0.6733 mL 1.3465 mL 3.3664 mL
25 mM 0.1077 mL 0.5386 mL 1.0772 mL 2.6931 mL
30 mM 0.0898 mL 0.4488 mL 0.8977 mL 2.2442 mL
40 mM 0.0673 mL 0.3366 mL 0.6733 mL 1.6832 mL
50 mM 0.0539 mL 0.2693 mL 0.5386 mL 1.3465 mL
60 mM 0.0449 mL 0.2244 mL 0.4488 mL 1.1221 mL
80 mM 0.0337 mL 0.1683 mL 0.3366 mL 0.8416 mL
100 mM 0.0269 mL 0.1347 mL 0.2693 mL 0.6733 mL
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Naphthol AS-MX phosphate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Naphthol AS-MX1596-56-1NASTRpEpigenetic Reader DomainInhibitorTranscription factor complexesAntitumor activityKRASLung cancerinhibitorinhibit

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