2. MAPK/ERK Pathway
  3. MEK
  4. Nedometinib

Nedometinib  (Synonyms: NFX-179)

Cat. No.: HY-156625 Purity: 98.25%
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Nedometinib is a tyrosine kinase inhibitor targeting to MEK1. Nedometinib has antineoplastic effect and can be used for research in dermatosis, cutaneous fibroneuroma, neurofibromatosis.

For research use only. We do not sell to patients.

Nedometinib Chemical Structure

Nedometinib Chemical Structure

CAS No. : 2252314-46-6

Size Price Stock Quantity
5 mg USD 340 In-stock
10 mg USD 540 In-stock
25 mg USD 1090 In-stock
50 mg USD 1750 In-stock
100 mg USD 2800 In-stock
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500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Nedometinib Related Antibodies

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MEK1 MEK2 MEK5 MEK

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Description

Nedometinib is a tyrosine kinase inhibitor targeting to MEK1. Nedometinib has antineoplastic effect and can be used for research in dermatosis, cutaneous fibroneuroma, neurofibromatosis[1].

IC50 & Target

MEK1[1]
Molecular Weight

470.24

Formula

C17H16FIN4O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=C(NC2=CC=C(C=C2F)I)N(C)C3=C1C=CC=N3)NOCCO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (212.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1266 mL 10.6329 mL 21.2657 mL
5 mM 0.4253 mL 2.1266 mL 4.2531 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1266 mL 10.6329 mL 21.2657 mL 53.1643 mL
5 mM 0.4253 mL 2.1266 mL 4.2531 mL 10.6329 mL
10 mM 0.2127 mL 1.0633 mL 2.1266 mL 5.3164 mL
15 mM 0.1418 mL 0.7089 mL 1.4177 mL 3.5443 mL
20 mM 0.1063 mL 0.5316 mL 1.0633 mL 2.6582 mL
25 mM 0.0851 mL 0.4253 mL 0.8506 mL 2.1266 mL
30 mM 0.0709 mL 0.3544 mL 0.7089 mL 1.7721 mL
40 mM 0.0532 mL 0.2658 mL 0.5316 mL 1.3291 mL
50 mM 0.0425 mL 0.2127 mL 0.4253 mL 1.0633 mL
60 mM 0.0354 mL 0.1772 mL 0.3544 mL 0.8861 mL
80 mM 0.0266 mL 0.1329 mL 0.2658 mL 0.6646 mL
100 mM 0.0213 mL 0.1063 mL 0.2127 mL 0.5316 mL
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Nedometinib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nedometinib2252314-46-6NFX-179NFX179NFX 179MEKMitogen-activated protein kinase kinaseMAPKKMAP2KInhibitorinhibitorinhibit

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