2. Cytoskeleton
  3. Integrin
  4. Nesvategrast

Nesvategrast (SF0166) is a potent and selective αvβ3 antagonist with IC50 values of 0.6 nM, 8 nM, and 13 nM for αvβ3, αvβ6, and αvβ8, respectively. Nesvategrast inhibits cellular adhesion to vitronectin across human, rat, rabbit, and dog cell lines with IC50 values of 7.6 pM to 76 nM. Nesvategrast decreases neovascularization in the oxygen-induced retinopathy mouse model.

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Nesvategrast Chemical Structure

Nesvategrast Chemical Structure

CAS No. : 1621332-91-9

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Nesvategrast Related Antibodies

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

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Description

Nesvategrast (SF0166) is a potent and selective αvβ3 antagonist with IC50 values of 0.6 nM, 8 nM, and 13 nM for αvβ3, αvβ6, and αvβ8, respectively. Nesvategrast inhibits cellular adhesion to vitronectin across human, rat, rabbit, and dog cell lines with IC50 values of 7.6 pM to 76 nM. Nesvategrast decreases neovascularization in the oxygen-induced retinopathy mouse model[1].

IC50 & Target[1]

αvβ3

0.6 nM (IC50)

αvβ6

8 nM (IC50)

αvβ8

13 nM (IC50)

In Vitro

Nesvategrast (0.5-4 μg; 12 days; chick chorioallantoic membrane (CAM) models) inhibits angiogenesis stimulated by basic fibroblast growth factor in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nesvategrast Related Antibodies
In Vivo

Nesvategrast (Bilateral eye topical drip 5% Nesvategrast) inhibits retinal neovascularization in 129SVE newborn mice with oxygen-induced retinopathy (OIR) models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female 129SVE newborn mice with oxygen-induced retinopathy (OIR) models[1]
Dosage: 5% SF0166
Administration: Bilateral eye topical drip 5% SF0166
Result: Reduced new blood vessel formation.
Clinical Trial
Molecular Weight

475.49

Formula

C23H27F2N5O4
CAS No.
SMILES

OC(C[C@@H](C1=CN=C(OC(F)F)C=C1)N2C(N(CCCC(N3)=CC=C4C3=NCCC4)CC2)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Nesvategrast Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nesvategrast1621332-91-9SF0166SF 0166SF-0166Integrincellular adhesionvitronectinchick chorioallantoic membraneneovascularizationInhibitorinhibitorinhibit

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