Nicotinic acid riboside

Name: Nicotinic acid riboside
Brand: MedChemExpress
SKU: HY-W104368
Rating: 4.5 (1 reviews)

Cat. No.: HY-W104368 Purity: 99.79%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Nicotinic acid riboside is a NAD⁺ precursor in human cells. Nicotinic acid riboside is an authentic intermediate of human NAD⁺ metabolism.

For research use only. We do not sell to patients.

Nicotinic acid riboside Chemical Structure

CAS No. : 17720-18-2

Size	Price	Stock	Quantity
5 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 280	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 750	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1200	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Nicotinic acid riboside is a NAD⁺ precursor in human cells. Nicotinic acid riboside is an authentic intermediate of human NAD⁺ metabolism^[1]^[2].

In Vitro

Nicotinic acid riboside (HepG2 cells; 0.01 nM~0.1 mM) helps FK866-treated cells to maintain viability at low micromolar concentrations^[1].
. Nicotinic acid riboside formation and release are caused by overexpression of FLAG-tagged CN-II and CN-III in HEK293 and HepG2 cells. CN-II and CN-III generate Nicotinic acid riboside in vitro by dephosphorylation of nicotinic acid mononucleotide (NAMN)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

255.22

Formula

C₁₁H₁₃NO₆

CAS No.

17720-18-2

Appearance

Solid

Color

White to off-white

SMILES

[O-]C(C1=C[N+]([C@@H]2O[C@@H]([C@H]([C@H]2O)O)CO)=CC=C1)=O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 62.5 mg/mL (244.89 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.9182 mL	19.5909 mL	39.1819 mL
5 mM	0.7836 mL	3.9182 mL	7.8364 mL
10 mM	0.3918 mL	1.9591 mL	3.9182 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (391.82 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.79%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (249 KB) HNMR (264 KB) LCMS (92 KB)

Handling Instructions (2659 KB)

References

[1]. Sasaki Y, et al. Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection. Exp Neurol. 2021;345:113842. [Content Brief]

[2]. Bogan KL, et al. Identification of Isn1 and Sdt1 as glucose- and vitamin-regulated nicotinamide mononucleotide and nicotinic acid mononucleotide [corrected] 5'-nucleotidases responsible for production of nicotinamide riboside and nicotinic acid riboside [ [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.9182 mL	19.5909 mL	39.1819 mL	97.9547 mL
	5 mM	0.7836 mL	3.9182 mL	7.8364 mL	19.5909 mL
	10 mM	0.3918 mL	1.9591 mL	3.9182 mL	9.7955 mL
	15 mM	0.2612 mL	1.3061 mL	2.6121 mL	6.5303 mL
	20 mM	0.1959 mL	0.9795 mL	1.9591 mL	4.8977 mL
	25 mM	0.1567 mL	0.7836 mL	1.5673 mL	3.9182 mL
	30 mM	0.1306 mL	0.6530 mL	1.3061 mL	3.2652 mL
	40 mM	0.0980 mL	0.4898 mL	0.9795 mL	2.4489 mL
	50 mM	0.0784 mL	0.3918 mL	0.7836 mL	1.9591 mL
	60 mM	0.0653 mL	0.3265 mL	0.6530 mL	1.6326 mL
	80 mM	0.0490 mL	0.2449 mL	0.4898 mL	1.2244 mL
	100 mM	0.0392 mL	0.1959 mL	0.3918 mL	0.9795 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.