2. NF-κB
  3. Keap1-Nrf2
  4. Nrf2 activator-2

Nrf2 activator-2 (compound O15), a Osthole derivative, is a potent Nrf2 agonist with an EC50 of 2.9 μM in 293 T cells. Nrf2 activator-2 effectively inhibits the interaction between Keap1 and Nrf2, thus showing the activation effect on Nrf2. Nrf2 activator-2 shows a marked decrease in the level of ubiquitinated Nrf2 in cells.

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Nrf2 activator-2 Chemical Structure

Nrf2 activator-2 Chemical Structure

CAS No. : 2770448-53-6

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Nrf2 activator-2 Related Antibodies

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Description

Nrf2 activator-2 (compound O15), a Osthole derivative, is a potent Nrf2 agonist with an EC50 of 2.9 μM in 293 T cells. Nrf2 activator-2 effectively inhibits the interaction between Keap1 and Nrf2, thus showing the activation effect on Nrf2. Nrf2 activator-2 shows a marked decrease in the level of ubiquitinated Nrf2 in cells[1].

Molecular Weight

385.25

Formula

C20H17BrO3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC1(CCC2=C3OC(C(C4=CC=CC=C4)=CC3=CC(Br)=C2O1)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (64.89 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5957 mL 12.9786 mL 25.9572 mL
5 mM 0.5191 mL 2.5957 mL 5.1914 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5957 mL 12.9786 mL 25.9572 mL 64.8929 mL
5 mM 0.5191 mL 2.5957 mL 5.1914 mL 12.9786 mL
10 mM 0.2596 mL 1.2979 mL 2.5957 mL 6.4893 mL
15 mM 0.1730 mL 0.8652 mL 1.7305 mL 4.3262 mL
20 mM 0.1298 mL 0.6489 mL 1.2979 mL 3.2446 mL
25 mM 0.1038 mL 0.5191 mL 1.0383 mL 2.5957 mL
30 mM 0.0865 mL 0.4326 mL 0.8652 mL 2.1631 mL
40 mM 0.0649 mL 0.3245 mL 0.6489 mL 1.6223 mL
50 mM 0.0519 mL 0.2596 mL 0.5191 mL 1.2979 mL
60 mM 0.0433 mL 0.2163 mL 0.4326 mL 1.0815 mL
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Nrf2 activator-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nrf2 activator-22770448-53-6Keap1-Nrf2Osthole293?T cellsKeap1ubiquitinated Nrf2Inhibitorinhibitorinhibit

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