2. NF-κB
  3. Keap1-Nrf2
  4. Nrf2-IN-3

Nrf2-IN-3 (Compound R16) is a Nrf2 inhibitor. Nrf2-IN-3 binds KEAP1 mutants (G333C mKEAP1) and repairs the disrupted KEAP1/NRF2 interactions. Nrf2-IN-3 sensitizes KEAP1-mutated cancer cells to Cisplatin (HY-17394) and Gefitinib (HY-50895) by repairing the mKEAP1/NRF2 complex.

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Nrf2-IN-3 Chemical Structure

Nrf2-IN-3 Chemical Structure

CAS No. : 6325-13-9

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Based on 1 publication(s) in Google Scholar

Nrf2-IN-3 Related Antibodies

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Description

Nrf2-IN-3 (Compound R16) is a Nrf2 inhibitor. Nrf2-IN-3 binds KEAP1 mutants (G333C mKEAP1) and repairs the disrupted KEAP1/NRF2 interactions. Nrf2-IN-3 sensitizes KEAP1-mutated cancer cells to Cisplatin (HY-17394) and Gefitinib (HY-50895) by repairing the mKEAP1/NRF2 complex[1].

Molecular Weight

442.53

Formula

C22H26N4O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CCCSCCCC(N/N=C/C1=C(O)C=CC=C1)=O)N/N=C/C2=C(O)C=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 116.67 mg/mL (263.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2597 mL 11.2987 mL 22.5973 mL
5 mM 0.4519 mL 2.2597 mL 4.5195 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2597 mL 11.2987 mL 22.5973 mL 56.4933 mL
5 mM 0.4519 mL 2.2597 mL 4.5195 mL 11.2987 mL
10 mM 0.2260 mL 1.1299 mL 2.2597 mL 5.6493 mL
15 mM 0.1506 mL 0.7532 mL 1.5065 mL 3.7662 mL
20 mM 0.1130 mL 0.5649 mL 1.1299 mL 2.8247 mL
25 mM 0.0904 mL 0.4519 mL 0.9039 mL 2.2597 mL
30 mM 0.0753 mL 0.3766 mL 0.7532 mL 1.8831 mL
40 mM 0.0565 mL 0.2825 mL 0.5649 mL 1.4123 mL
50 mM 0.0452 mL 0.2260 mL 0.4519 mL 1.1299 mL
60 mM 0.0377 mL 0.1883 mL 0.3766 mL 0.9416 mL
80 mM 0.0282 mL 0.1412 mL 0.2825 mL 0.7062 mL
100 mM 0.0226 mL 0.1130 mL 0.2260 mL 0.5649 mL
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Nrf2-IN-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nrf2-IN-36325-13-9Keap1-Nrf2cancerantitumorCisplatinGefitinibKEAP1 mutantInhibitorinhibitorinhibit

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