2. Stem Cell/Wnt
  3. β-catenin
  4. NRX-2663

NRX-2663 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-2663 enhances the binding of β-catenin peptide for β-TrCP with an EC50 of 22.9 µM and a Kd of 54.8 nM.

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NRX-2663 Chemical Structure

NRX-2663 Chemical Structure

CAS No. : 2763260-34-8

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1 mg USD 264 In-stock
5 mg USD 660 In-stock
10 mg USD 1050 In-stock
25 mg USD 2100 In-stock
50 mg USD 3350 In-stock
100 mg USD 5400 In-stock
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Based on 1 publication(s) in Google Scholar

NRX-2663 Related Antibodies

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Description

NRX-2663 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-2663 enhances the binding of β-catenin peptide for β-TrCP with an EC50 of 22.9 µM and a Kd of 54.8 nM[1].

IC50 & Target

EC50: 22.9 µM (β-catenin:β-TrCP Interaction)[1]
Kd: 54.8 nM (β-catenin:β-TrCP Interaction)[1]
In Vitro

NRX-2663 displays both improved potency in the binding assay with pSer33/Ser37 β-catenin (EC50 of 80 µM) and cooperativity of binding (13-fold). NRX-2663 also markedly enhances the ubiquitylation of the pSer33/Ser37 β-catenin peptide, with ubiquitin chain formation at ligand concentrations of 16 μM and above resembling ubiquitin chain formation on wild-type pSer33/pSer37 β-catenin peptide[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NRX-2663 Related Antibodies
Molecular Weight

418.32

Formula

C20H13F3N2O5
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

OC(C1=CC=CC(NC(C2=C(C=C(NC2=O)C(F)(F)F)OC3=CC=CC=C3)=O)=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (239.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3905 mL 11.9526 mL 23.9051 mL
5 mM 0.4781 mL 2.3905 mL 4.7810 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3905 mL 11.9526 mL 23.9051 mL 59.7629 mL
5 mM 0.4781 mL 2.3905 mL 4.7810 mL 11.9526 mL
10 mM 0.2391 mL 1.1953 mL 2.3905 mL 5.9763 mL
15 mM 0.1594 mL 0.7968 mL 1.5937 mL 3.9842 mL
20 mM 0.1195 mL 0.5976 mL 1.1953 mL 2.9881 mL
25 mM 0.0956 mL 0.4781 mL 0.9562 mL 2.3905 mL
30 mM 0.0797 mL 0.3984 mL 0.7968 mL 1.9921 mL
40 mM 0.0598 mL 0.2988 mL 0.5976 mL 1.4941 mL
50 mM 0.0478 mL 0.2391 mL 0.4781 mL 1.1953 mL
60 mM 0.0398 mL 0.1992 mL 0.3984 mL 0.9960 mL
80 mM 0.0299 mL 0.1494 mL 0.2988 mL 0.7470 mL
100 mM 0.0239 mL 0.1195 mL 0.2391 mL 0.5976 mL
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NRX-2663 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NRX-26632763260-34-8NRX2663NRX 2663β-cateninBeta cateninE3ligasedegradationmutantSCFβ-TrCPPPISer33Ser37Inhibitorinhibitorinhibit

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