2. Epigenetics
  3. Histone Methyltransferase
  4. NSD2 ligand 1

NSD2 ligand 1 is a NSD2 ligand. NSD2 ligand 1 can be used for synthesis of LLC0424 (HY-161574) (a PROTAC NSD2 degrader).

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NSD2 ligand 1 Chemical Structure

NSD2 ligand 1 Chemical Structure

Size Price Stock Quantity
5 mg USD 280 In-stock
10 mg USD 465 In-stock
25 mg USD 980 In-stock
50 mg USD 1620 In-stock
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NSD2 ligand 1 Related Antibodies

Top Publications Citing Use of Products

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • Biological Activity

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Description

NSD2 ligand 1 is a NSD2 ligand. NSD2 ligand 1 can be used for synthesis of LLC0424 (HY-161574) (a PROTAC NSD2 degrader)[1].

IC50 & Target

NSD2[1]
Molecular Weight

457.48

Formula

C26H23N3O5
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1)COC2=C1C=CC(C(N(C3CC3)CC4=CC=C(C(NC5=CC=C(O)C=C5)=O)C=C4)=O)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (218.59 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1859 mL 10.9294 mL 21.8589 mL
5 mM 0.4372 mL 2.1859 mL 4.3718 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1859 mL 10.9294 mL 21.8589 mL 54.6472 mL
5 mM 0.4372 mL 2.1859 mL 4.3718 mL 10.9294 mL
10 mM 0.2186 mL 1.0929 mL 2.1859 mL 5.4647 mL
15 mM 0.1457 mL 0.7286 mL 1.4573 mL 3.6431 mL
20 mM 0.1093 mL 0.5465 mL 1.0929 mL 2.7324 mL
25 mM 0.0874 mL 0.4372 mL 0.8744 mL 2.1859 mL
30 mM 0.0729 mL 0.3643 mL 0.7286 mL 1.8216 mL
40 mM 0.0546 mL 0.2732 mL 0.5465 mL 1.3662 mL
50 mM 0.0437 mL 0.2186 mL 0.4372 mL 1.0929 mL
60 mM 0.0364 mL 0.1822 mL 0.3643 mL 0.9108 mL
80 mM 0.0273 mL 0.1366 mL 0.2732 mL 0.6831 mL
100 mM 0.0219 mL 0.1093 mL 0.2186 mL 0.5465 mL
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NSD2 ligand 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSD2 ligand 1Histone MethyltransferaseNSD2 ligandInhibitorinhibitorinhibit

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