2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. ONT-993

ONT-993  (Synonyms: AR 00440993)

Cat. No.: HY-151239 Purity: 95.13%
COA Handling Instructions

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ONT-993 is an aliphatic hydroxylated metabolite. ONT-993 inhibits CYP2D6 (IC50=7.9 µM) and causes metabolism-dependent inactivation of CYP3A (KI=1.6 µM).

For research use only. We do not sell to patients.

ONT-993 Chemical Structure

ONT-993 Chemical Structure

CAS No. : 937263-81-5

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5 mg USD 145 In-stock
10 mg USD 230 In-stock
25 mg USD 450 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

ONT-993 is an aliphatic hydroxylated metabolite. ONT-993 inhibits CYP2D6 (IC50=7.9 µM) and causes metabolism-dependent inactivation of CYP3A (KI=1.6 µM)[1].

IC50 & Target

CYP2D6

7.9 μM (IC50)

Molecular Weight

496.52

Formula

C26H24N8O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OCC1(C)N=C(NC2=CC3=C(NC4=CC=C(C(C)=C4)OC5=CC6=NC=NN6C=C5)N=CN=C3C=C2)OC1
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (100.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0140 mL 10.0701 mL 20.1402 mL
5 mM 0.4028 mL 2.0140 mL 4.0280 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0140 mL 10.0701 mL 20.1402 mL 50.3504 mL
5 mM 0.4028 mL 2.0140 mL 4.0280 mL 10.0701 mL
10 mM 0.2014 mL 1.0070 mL 2.0140 mL 5.0350 mL
15 mM 0.1343 mL 0.6713 mL 1.3427 mL 3.3567 mL
20 mM 0.1007 mL 0.5035 mL 1.0070 mL 2.5175 mL
25 mM 0.0806 mL 0.4028 mL 0.8056 mL 2.0140 mL
30 mM 0.0671 mL 0.3357 mL 0.6713 mL 1.6783 mL
40 mM 0.0504 mL 0.2518 mL 0.5035 mL 1.2588 mL
50 mM 0.0403 mL 0.2014 mL 0.4028 mL 1.0070 mL
60 mM 0.0336 mL 0.1678 mL 0.3357 mL 0.8392 mL
80 mM 0.0252 mL 0.1259 mL 0.2518 mL 0.6294 mL
100 mM 0.0201 mL 0.1007 mL 0.2014 mL 0.5035 mL
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ONT-993 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ONT-993937263-81-5AR 00440993ONT993ONT 993AR00440993AR-00440993Cytochrome P450CYPsInhibitorinhibitorinhibit

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