2. Anti-infection
  3. Parasite
  4. Oxfendazole

Oxfendazole is a sulfoxide form of fenbendazole that is effective when taken orally. Oxfendazole fights parasites and has tumor-promoting activity.

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Oxfendazole Chemical Structure

Oxfendazole Chemical Structure

CAS No. : 53716-50-0

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Based on 2 publication(s) in Google Scholar

Other Forms of Oxfendazole:

Oxfendazole Related Antibodies

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Oxfendazole is a sulfoxide form of fenbendazole that is effective when taken orally. Oxfendazole fights parasites and has tumor-promoting activity[1][2][3].

In Vivo

Oxfendazole (30 mg/kg, oral, single dose) is effective in preventing and controlling natural infections of gastrointestinal nematodes in pigs[1].
Oxfendazole (0-500 mg/kg, oral, 8 weeks) has the potential to promote liver tumors in rats[2].
Pharmacokinetic parameters of Oxfendazole administered in different doses to goats through the rumen or directly into the reticulum[3]

Route Dose (mg/kg) AUC (μg/mL•h) Cmax (μg/mL) Tmax (h) βT1/2 (h)
Intraruminal 5 12.7 0.35 12 6.5
Intraruminal 10 26.7 0.55 15.5 8.5
Intraruminal 20 35.8 0.61 17.6 9.1
Intra-abomasal 10 18.3 0.9 4.1 /

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Naturally parasitized pigs[1]
Dosage: 30 mg/kg; single dose
Administration: Oral
Result: Was effective against natural infections in piglets caused by adult roundworms, esophageal tapeworms, pig tapeworms, and giant roundworms.
Animal Model: Fisher 344 rat[2]
Dosage: 0, 10, 100, 250, 500 mg/kg; 8 weeks
Administration: Oral
Result: Led to an increase in relative liver weight, with noticeable hypertrophy of centrilobular hepatocytes, a significant increase in smooth endoplasmic reticulum in liver cells, and a marked rise in the number of placental form glutathione S-transferase positive single cells.
Clinical Trial
Molecular Weight

315.35

Formula

C15H13N3O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(OC)NC1=NC2=CC=C(S(C3=CC=CC=C3)=O)C=C2N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 31.25 mg/mL (99.10 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 0.67 mg/mL (2.12 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1711 mL 15.8554 mL 31.7108 mL
5 mM 0.6342 mL 3.1711 mL 6.3422 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (7.93 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (6.60 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.29%

COA (248 KB) HNMR (273 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 3.1711 mL 15.8554 mL 31.7108 mL 79.2770 mL
DMSO 5 mM 0.6342 mL 3.1711 mL 6.3422 mL 15.8554 mL
10 mM 0.3171 mL 1.5855 mL 3.1711 mL 7.9277 mL
15 mM 0.2114 mL 1.0570 mL 2.1141 mL 5.2851 mL
20 mM 0.1586 mL 0.7928 mL 1.5855 mL 3.9638 mL
25 mM 0.1268 mL 0.6342 mL 1.2684 mL 3.1711 mL
30 mM 0.1057 mL 0.5285 mL 1.0570 mL 2.6426 mL
40 mM 0.0793 mL 0.3964 mL 0.7928 mL 1.9819 mL
50 mM 0.0634 mL 0.3171 mL 0.6342 mL 1.5855 mL
60 mM 0.0529 mL 0.2643 mL 0.5285 mL 1.3213 mL
80 mM 0.0396 mL 0.1982 mL 0.3964 mL 0.9910 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Oxfendazole Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oxfendazole53716-50-0ParasiteAntiparasitictumor promotinggoatInhibitorinhibitorinhibit

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