P-CAB agent 2 hydrochloride

Name: P-CAB agent 2 hydrochloride
Brand: MedChemExpress
SKU: HY-153219
Rating: 4.5 (1 reviews)

Cat. No.: HY-153219 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

P-CAB agent 2 hydrochloride is a potent and orally active potassium-competitive acid blocker and a gastric acid secretion inhibitor. P-CAB agent 2 hydrochloride inhibits H⁺/K⁺-ATPase activity with an IC₅₀ value of <100 nM. P-CAB agent 2 hydrochloride inhibits the hERG potassium channel with an IC₅₀ value of 18.69 M. P-CAB agent 2 hydrochloride shows no acute toxicity and inhibits histamine (HY-B1204)-induced gastric acid secretion.

For research use only. We do not sell to patients.

P-CAB agent 2 hydrochloride Chemical Structure

CAS No. : 2209911-80-6

Size	Price	Stock	Quantity
5 mg	USD 323	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 517	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1035	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1656	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2650	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of P-CAB agent 2 hydrochloride:

P-CAB agent 2 Get quote

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

P-CAB agent 2 hydrochloride (100 µM) inhibits the hERG potassium channel with an inhibition rate of 86.21% and an IC₅₀ value of 18.69 M^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

P-CAB agent 2 hydrochloride (example 1) inhibits histamine (HY-B1204)-induced gastric acid secretion in SD rats^[1].
P-CAB agent 2 hydrochloride (600, 2000 mg/kg; p.o.; once) shows no acute toxicity and 600mg/kg shows no significant effect on animal body weight in SD rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	180-220 g, SPF grade, male SD rats^[1]
Dosage:	2 mg/kg
Administration:	P.o.; once
Result:	Inhibited histamine-induced gastric acid secretion with the acid suppression rate of 55.4%.

Molecular Weight

468.97

Formula

C₂₂H₂₆ClFN₂O₄S

CAS No.

2209911-80-6

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=S(C1=CC(OCCCOC)=CC=C1)(N2C=C(CNC)C=C2C3=C(F)C=CC=C3)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (213.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1323 mL	10.6617 mL	21.3233 mL
5 mM	0.4265 mL	2.1323 mL	4.2647 mL
10 mM	0.2132 mL	1.0662 mL	2.1323 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.33 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.33 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (5.33 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (250 KB) HNMR (258 KB) RP-HPLC (384 KB)

Handling Instructions (2659 KB)

References

[1]. YinLin Qin, et al. Pyrrole sulfonyl derivative, and preparation method and medical use thereof. WO2016119505A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1323 mL	10.6617 mL	21.3233 mL	53.3083 mL
	5 mM	0.4265 mL	2.1323 mL	4.2647 mL	10.6617 mL
	10 mM	0.2132 mL	1.0662 mL	2.1323 mL	5.3308 mL
	15 mM	0.1422 mL	0.7108 mL	1.4216 mL	3.5539 mL
	20 mM	0.1066 mL	0.5331 mL	1.0662 mL	2.6654 mL
	25 mM	0.0853 mL	0.4265 mL	0.8529 mL	2.1323 mL
	30 mM	0.0711 mL	0.3554 mL	0.7108 mL	1.7769 mL
	40 mM	0.0533 mL	0.2665 mL	0.5331 mL	1.3327 mL
	50 mM	0.0426 mL	0.2132 mL	0.4265 mL	1.0662 mL
	60 mM	0.0355 mL	0.1777 mL	0.3554 mL	0.8885 mL
	80 mM	0.0267 mL	0.1333 mL	0.2665 mL	0.6664 mL
	100 mM	0.0213 mL	0.1066 mL	0.2132 mL	0.5331 mL