2. NF-κB Stem Cell/Wnt Immunology/Inflammation
  3. Wnt Toll-like Receptor (TLR) β-catenin RANKL/RANK
  4. Pamidronate disodium

Pamidronate disodium  (Synonyms: CGP 23339A)

Cat. No.: HY-B0012A Purity: ≥98.0%
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Pamidronate disodium, the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronate disodium significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of OPG in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronate disodium can inhibit the signaling of Wnt and β-catenin, and is applicable for research on osteoporosis and osteosarcoma.

For research use only. We do not sell to patients.

Pamidronate disodium Chemical Structure

Pamidronate disodium Chemical Structure

CAS No. : 57248-88-1

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5 mg USD 46 In-stock
10 mg USD 72 In-stock
50 mg USD 276 In-stock
100 mg USD 415 In-stock
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Based on 1 publication(s) in Google Scholar

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Pamidronate disodium Related Antibodies

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1 Publications Citing Use of MCE Pamidronate disodium

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Description

Pamidronate disodium, the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronate disodium significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of OPG in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronate disodium can inhibit the signaling of Wnt and β-catenin, and is applicable for research on osteoporosis and osteosarcoma[1][2][3][4].

Clinical Trial
Molecular Weight

279.03

Formula

C3H9NNa2O7P2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OP(C(O)(P(O)(O[Na])=O)CCN)(O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (179.19 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5838 mL 17.9192 mL 35.8384 mL
5 mM 0.7168 mL 3.5838 mL 7.1677 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.5838 mL 17.9192 mL 35.8384 mL 89.5961 mL
5 mM 0.7168 mL 3.5838 mL 7.1677 mL 17.9192 mL
10 mM 0.3584 mL 1.7919 mL 3.5838 mL 8.9596 mL
15 mM 0.2389 mL 1.1946 mL 2.3892 mL 5.9731 mL
20 mM 0.1792 mL 0.8960 mL 1.7919 mL 4.4798 mL
25 mM 0.1434 mL 0.7168 mL 1.4335 mL 3.5838 mL
30 mM 0.1195 mL 0.5973 mL 1.1946 mL 2.9865 mL
40 mM 0.0896 mL 0.4480 mL 0.8960 mL 2.2399 mL
50 mM 0.0717 mL 0.3584 mL 0.7168 mL 1.7919 mL
60 mM 0.0597 mL 0.2987 mL 0.5973 mL 1.4933 mL
80 mM 0.0448 mL 0.2240 mL 0.4480 mL 1.1200 mL
100 mM 0.0358 mL 0.1792 mL 0.3584 mL 0.8960 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Pamidronate disodium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pamidronate disodium57248-88-1CGP 23339AWntToll-like Receptor (TLR)β-cateninRANKL/RANKBeta cateninosteoarthritis (OA)osteosarcomaosteoporosisInhibitorinhibitorinhibit

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