Patchouli alcohol

Name: Patchouli alcohol
Brand: MedChemExpress
SKU: HY-N0207
Rating: 4.5 (1 reviews)

Cat. No.: HY-N0207 Purity: 99.38%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Patchouli alcohol is a natural tricyclic sesquiterpene, exhibits anti-Helicobacter pylori, anti-inflammatory and antioxidant properties.

For research use only. We do not sell to patients.

Patchouli alcohol Chemical Structure

CAS No. : 5986-55-0

Size	Price	Stock	Quantity
5 mg	USD 25	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 35	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Patchouli alcohol:

Patchouli alcohol (Standard) Get quote

1 Publications Citing Use of MCE Patchouli alcohol

•Acta Pharmacol Sin. 2022 Jan 28. [Abstract]

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Patchouli alcohol is a natural tricyclic sesquiterpene, exhibits anti-Helicobacter pylori, anti-inflammatory and antioxidant properties^[1].

In Vitro

Patchouli alcohol (5-20 μg/mL; 24 h) not only significantly increases the cell viability and decreased cellular lactate dehydrogenase (LDH) leakage, but also markedly elevates the mitochondrial membrane potential and remarkably attenuated GES-1 cellular apoptosis, thereby protecting gastric epithelial cells against injuries caused by H. pylori. Patchouli alcohol also inhibits the secretions of pro-inflammatory factors, such as MCP-1, TNF-α and IL-6^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	GES-1 cells treated with H. pylori
Concentration:	5 μg/mL, 10 μg/mL, and 20 μg/mL
Incubation Time:	24 h
Result:	Significantly increased the cell viability and decreased cellular lactate dehydrogenase (LDH) leakage.

In Vivo

Patchouli alcohol (5-20 mg/kg; oral administration; for 2 weeks) significantly protects the gastric mucosa from H. pylori-induced damage. Patchouli alcohol effectively attenuates oxidative stress by decreasing contents of intracellular ROS and MDA, and increasing levels of NP-SH, GSH/GSSG. Patchouli alcohol significantly attenuates the secretions of IL-1β, keratinocyte chemoattractant and IL-6^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Five- to six-week-old male C57BL/6 mice injected with H. pylori^[1]
Dosage:	5, 10, and 20 mg/kg
Administration:	Oral administration; for 2 weeks
Result:	Effectively attenuated oxidative stress by decreasing contents of intracellular reactive oxygen species (ROS) and MDA, and increasing levels of non-protein sulfhydryl (NP-SH), catalase and glutathione (GSH)/glutathione disulphide (GSSG).

Molecular Weight

222.37

Formula

C₁₅H₂₆O

CAS No.

5986-55-0

Appearance

Solid

Color

White to off-white

SMILES

O[C@@]1(C2(C)C)CC[C@H](C)[C@]3([H])C[C@@]2([H])CC[C@]13C

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (449.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 20 mg/mL (89.94 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.4970 mL	22.4850 mL	44.9701 mL
5 mM	0.8994 mL	4.4970 mL	8.9940 mL
10 mM	0.4497 mL	2.2485 mL	4.4970 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 6.25 mg/mL (28.11 mM); Clear solution

This protocol yields a clear solution of ≥ 6.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (62.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 6.25 mg/mL (28.11 mM); Clear solution

This protocol yields a clear solution of ≥ 6.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (62.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 6.25 mg/mL (28.11 mM); Clear solution

This protocol yields a clear solution of ≥ 6.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (62.5 mg/mL) to 900 μL Corn oil, and mix evenly.
Protocol 4

Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2 mg/mL (8.99 mM); Clear solution

This protocol yields a clear solution of ≥ 2 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (20.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 5

Add each solvent one by one: 10% EtOH 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2 mg/mL (8.99 mM); Clear solution

This protocol yields a clear solution of ≥ 2 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (20.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 6

Add each solvent one by one: 10% EtOH 90% Corn Oil
Solubility: ≥ 2 mg/mL (8.99 mM); Clear solution

This protocol yields a clear solution of ≥ 2 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (20.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.38%

Select Batch:

Data Sheet (278 KB) SDS (393 KB)

COA (253 KB) HNMR (248 KB) GC (171 KB)

Handling Instructions (2659 KB)

References

[1]. Lian DW, et al. Unraveling the Novel Protective Effect of Patchouli Alcohol Against Helicobacter pylori-Induced Gastritis: Insights Into the Molecular Mechanism in vitro and in vivo. Front Pharmacol. 2018 Nov 22;9:1347. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol / DMSO	1 mM	4.4970 mL	22.4850 mL	44.9701 mL	112.4252 mL
	5 mM	0.8994 mL	4.4970 mL	8.9940 mL	22.4850 mL
	10 mM	0.4497 mL	2.2485 mL	4.4970 mL	11.2425 mL
	15 mM	0.2998 mL	1.4990 mL	2.9980 mL	7.4950 mL
	20 mM	0.2249 mL	1.1243 mL	2.2485 mL	5.6213 mL
	25 mM	0.1799 mL	0.8994 mL	1.7988 mL	4.4970 mL
	30 mM	0.1499 mL	0.7495 mL	1.4990 mL	3.7475 mL
	40 mM	0.1124 mL	0.5621 mL	1.1243 mL	2.8106 mL
	50 mM	0.0899 mL	0.4497 mL	0.8994 mL	2.2485 mL
	60 mM	0.0750 mL	0.3748 mL	0.7495 mL	1.8738 mL
	80 mM	0.0562 mL	0.2811 mL	0.5621 mL	1.4053 mL
DMSO	100 mM	0.0450 mL	0.2249 mL	0.4497 mL	1.1243 mL