PC SPDP-NHS carbonate ester

Name: PC SPDP-NHS carbonate ester
Brand: MedChemExpress
SKU: HY-140138
Rating: 4.5 (1 reviews)

Cat. No.: HY-140138 Purity: ≥95.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

PC SPDP-NHS carbonate ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

PC SPDP-NHS carbonate ester Chemical Structure

CAS No. : 2279944-61-3

Size	Price	Stock	Quantity
1 mg	USD 210	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 525	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All ADC Linker Isoform Specific Products:

View All Isoforms

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

Biological Activity
Purity & Documentation
References
Customer Review

Description

PC SPDP-NHS carbonate ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1].

IC₅₀ & Target

Disulfide Cleavable Linker

Cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

608.64

Formula

C₂₅H₂₈N₄O₁₀S₂

CAS No.

2279944-61-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(CCCOC1=CC([N+]([O-])=O)=C(C(C)OC(ON2C(CCC2=O)=O)=O)C=C1OC)NCCSSC3=NC=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

Chloroform : 50 mg/mL (82.15 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6430 mL	8.2150 mL	16.4301 mL
5 mM	0.3286 mL	1.6430 mL	3.2860 mL
10 mM	0.1643 mL	0.8215 mL	1.6430 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (269 KB) SDS (393 KB)

COA (246 KB) HNMR (288 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Chloroform	1 mM	1.6430 mL	8.2150 mL	16.4301 mL	41.0752 mL
	5 mM	0.3286 mL	1.6430 mL	3.2860 mL	8.2150 mL
	10 mM	0.1643 mL	0.8215 mL	1.6430 mL	4.1075 mL
	15 mM	0.1095 mL	0.5477 mL	1.0953 mL	2.7383 mL
	20 mM	0.0822 mL	0.4108 mL	0.8215 mL	2.0538 mL
	25 mM	0.0657 mL	0.3286 mL	0.6572 mL	1.6430 mL
	30 mM	0.0548 mL	0.2738 mL	0.5477 mL	1.3692 mL
	40 mM	0.0411 mL	0.2054 mL	0.4108 mL	1.0269 mL
	50 mM	0.0329 mL	0.1643 mL	0.3286 mL	0.8215 mL
	60 mM	0.0274 mL	0.1369 mL	0.2738 mL	0.6846 mL
	80 mM	0.0205 mL	0.1027 mL	0.2054 mL	0.5134 mL