2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. PC SPDP-NHS carbonate ester

PC SPDP-NHS carbonate ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

PC SPDP-NHS carbonate ester Chemical Structure

PC SPDP-NHS carbonate ester Chemical Structure

CAS No. : 2279944-61-3

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1 mg USD 210 In-stock
5 mg USD 525 In-stock
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Based on 1 publication(s) in Google Scholar

PC SPDP-NHS carbonate ester Related Antibodies

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Description

PC SPDP-NHS carbonate ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target

Disulfide Cleavable Linker

 

Cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PC SPDP-NHS carbonate ester Related Antibodies
Molecular Weight

608.64

Formula

C25H28N4O10S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CCCOC1=CC([N+]([O-])=O)=C(C(C)OC(ON2C(CCC2=O)=O)=O)C=C1OC)NCCSSC3=NC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

Chloroform : 50 mg/mL (82.15 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6430 mL 8.2150 mL 16.4301 mL
5 mM 0.3286 mL 1.6430 mL 3.2860 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Chloroform 1 mM 1.6430 mL 8.2150 mL 16.4301 mL 41.0752 mL
5 mM 0.3286 mL 1.6430 mL 3.2860 mL 8.2150 mL
10 mM 0.1643 mL 0.8215 mL 1.6430 mL 4.1075 mL
15 mM 0.1095 mL 0.5477 mL 1.0953 mL 2.7383 mL
20 mM 0.0822 mL 0.4108 mL 0.8215 mL 2.0538 mL
25 mM 0.0657 mL 0.3286 mL 0.6572 mL 1.6430 mL
30 mM 0.0548 mL 0.2738 mL 0.5477 mL 1.3692 mL
40 mM 0.0411 mL 0.2054 mL 0.4108 mL 1.0269 mL
50 mM 0.0329 mL 0.1643 mL 0.3286 mL 0.8215 mL
60 mM 0.0274 mL 0.1369 mL 0.2738 mL 0.6846 mL
80 mM 0.0205 mL 0.1027 mL 0.2054 mL 0.5134 mL
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PC SPDP-NHS carbonate ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PC SPDP-NHS carbonate ester2279944-61-3ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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PC SPDP-NHS carbonate ester
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