2. Epigenetics Apoptosis
  3. Histone Methyltransferase Apoptosis
  4. PRMT6-IN-3

PRMT6-IN-3 (compound 25) is a selective PRMT6 inhibitor with an IC50 value of 192 nM. PRMT6-IN-3 can induce apoptosis in cancer cells and has anticancer activity.

For research use only. We do not sell to patients.

PRMT6-IN-3 Chemical Structure

PRMT6-IN-3 Chemical Structure

CAS No. : 2890765-10-1

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Based on 1 publication(s) in Google Scholar

PRMT6-IN-3 Related Antibodies

Top Publications Citing Use of Products

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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Description

PRMT6-IN-3 (compound 25) is a selective PRMT6 inhibitor with an IC50 value of 192 nM. PRMT6-IN-3 can induce apoptosis in cancer cells and has anticancer activity[1].
In Vitro

PRMT6-IN-3(compound 25) (80 μM, 3-7 days) has anti-proliferative activity against HCC827 and MDA-MB-435 cells[1].
PRMT6-IN-3(compound 25) (0-40 μM, 72 h) significantly induces apoptosis of cancer cells in a dose-dependent manner. Among them, a concentration of 40 μM could induce apoptosis in 43.44% and 35.08% of HCC827 and MDA-MB-435 cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PRMT6-IN-3 Related Antibodies
In Vivo

The pharmacokinetic parameters of PRMT6-IN-3(compound 25) in rat

Parameters iv (2 mg/kg) po (10 mg/kg)
Tmax (h) 0.08 0.33
T1/2 (h) 1.46 1.63
AUC(0-t)(ng*h/mL) 661.50 123.53
MRT(0-t) (h) 1.24 1.86
Cmax (ng/mL) - 88.32
F (%) - 3.73

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

374.50

Formula

C19H26N4O2S
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=S(C1CC1)(NC2=CC=C(C3=CC(CN(C)CCNC)=CN=C3)C=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 55 mg/mL (146.86 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6702 mL 13.3511 mL 26.7023 mL
5 mM 0.5340 mL 2.6702 mL 5.3405 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.66%

SDS (393 KB)

COA (244 KB) HNMR (247 KB) RP-HPLC (148 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6702 mL 13.3511 mL 26.7023 mL 66.7557 mL
5 mM 0.5340 mL 2.6702 mL 5.3405 mL 13.3511 mL
10 mM 0.2670 mL 1.3351 mL 2.6702 mL 6.6756 mL
15 mM 0.1780 mL 0.8901 mL 1.7802 mL 4.4504 mL
20 mM 0.1335 mL 0.6676 mL 1.3351 mL 3.3378 mL
25 mM 0.1068 mL 0.5340 mL 1.0681 mL 2.6702 mL
30 mM 0.0890 mL 0.4450 mL 0.8901 mL 2.2252 mL
40 mM 0.0668 mL 0.3338 mL 0.6676 mL 1.6689 mL
50 mM 0.0534 mL 0.2670 mL 0.5340 mL 1.3351 mL
60 mM 0.0445 mL 0.2225 mL 0.4450 mL 1.1126 mL
80 mM 0.0334 mL 0.1669 mL 0.3338 mL 0.8344 mL
100 mM 0.0267 mL 0.1335 mL 0.2670 mL 0.6676 mL
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PRMT6-IN-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PRMT6-IN-32890765-10-1Histone MethyltransferaseApoptosisPRMT6apoptosisanticancerInhibitorinhibitorinhibit

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