(R)-I-BET762 carboxylic acid (Synonyms: (R)-Molibresib carboxylic acid; (R)-GSK525762A carboxylic acid; (R)-PROTAC BRD4-binding moiety 2)

Cat. No.: HY-107443A: FAQs
Data Sheet Handling Instructions

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(R)-I-BET762 carboxylic acid, the R-enantiomer of I-BET762 carboxylic acid (HY-107443). I-BET762 carboxylic acid is an I-BET762-based warhead ligand for conjugation reactions of PROTAC targeting on BET. I-BET762 carboxylic acid is a BRD4 inhibitor with a pIC₅₀ of 5.1.

For research use only. We do not sell to patients.

(R)-I-BET762 carboxylic acid Chemical Structure

CAS No. : 1786401-70-4

Size	Price	Stock	Quantity
5 mg	USD 455	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 760	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1600	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2560	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 4100	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Other Forms of (R)-I-BET762 carboxylic acid:

I-BET762 carboxylic acid In-stock

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Purity & Documentation
References
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Description

Molecular Weight

396.83

Formula

C₂₀H₁₇ClN₄O₃

CAS No.

1786401-70-4

SMILES

CC1=NN=C2[C@@H](CC(O)=O)N=C(C3=CC=C(Cl)C=C3)C4=C(C=CC(OC)=C4)N21

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (252.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5200 mL	12.5999 mL	25.1997 mL
5 mM	0.5040 mL	2.5200 mL	5.0399 mL
10 mM	0.2520 mL	1.2600 mL	2.5200 mL

View the Complete Stock Solution Preparation Table

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mirguet O, et al. Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains. J Med Chem. 2013 Oct 10;56(19):7501-15. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5200 mL	12.5999 mL	25.1997 mL	62.9993 mL
	5 mM	0.5040 mL	2.5200 mL	5.0399 mL	12.5999 mL
	10 mM	0.2520 mL	1.2600 mL	2.5200 mL	6.2999 mL
	15 mM	0.1680 mL	0.8400 mL	1.6800 mL	4.2000 mL
	20 mM	0.1260 mL	0.6300 mL	1.2600 mL	3.1500 mL
	25 mM	0.1008 mL	0.5040 mL	1.0080 mL	2.5200 mL
	30 mM	0.0840 mL	0.4200 mL	0.8400 mL	2.1000 mL
	40 mM	0.0630 mL	0.3150 mL	0.6300 mL	1.5750 mL
	50 mM	0.0504 mL	0.2520 mL	0.5040 mL	1.2600 mL
	60 mM	0.0420 mL	0.2100 mL	0.4200 mL	1.0500 mL
	80 mM	0.0315 mL	0.1575 mL	0.3150 mL	0.7875 mL
	100 mM	0.0252 mL	0.1260 mL	0.2520 mL	0.6300 mL

(R)-I-BET762 carboxylic acid Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-I-BET762 carboxylic acid1786401-70-4(R)-Molibresib carboxylic acid (R)-GSK525762A carboxylic acid (R)-PROTAC BRD4-binding moiety 2Ligands for Target Protein for PROTACEpigenetic Reader DomainTarget Protein-binding MoietyR-enantiomerI-BET762 carboxylic acidBRD4Inhibitorinhibitorinhibit

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