2. PROTAC Epigenetics
  3. Ligands for Target Protein for PROTAC Epigenetic Reader Domain
  4. I-BET762 carboxylic acid

I-BET762 carboxylic acid  (Synonyms: Molibresib carboxylic acid; GSK525762A carboxylic acid; PROTAC BRD4-binding moiety 2)

Cat. No.: HY-107443 Purity: 98.20%
COA Handling Instructions

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I-BET762 carboxylic acid (Molibresib carboxylic acid) is an I-BET762-based warhead ligand for conjugation reactions of PROTAC targeting on BET. I-BET762 carboxylic acid (Molibresib carboxylic acid) is a BRD4 inhibitor with a pIC50 of 5.1.

For research use only. We do not sell to patients.

I-BET762 carboxylic acid Chemical Structure

I-BET762 carboxylic acid Chemical Structure

CAS No. : 1300019-38-8

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Based on 1 publication(s) in Google Scholar

Other Forms of I-BET762 carboxylic acid:

I-BET762 carboxylic acid Related Antibodies

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Description

I-BET762 carboxylic acid (Molibresib carboxylic acid) is an I-BET762-based warhead ligand for conjugation reactions of PROTAC targeting on BET. I-BET762 carboxylic acid (Molibresib carboxylic acid) is a BRD4 inhibitor with a pIC50 of 5.1[1].

IC50 & Target

BRD4

5.1 (pIC50)

In Vitro

I-BET762 carboxylic acid (Molibresib carboxylic acid) (Compound 27) inhibits peripheral blood mononuclear cells (PBMC) with a pIC50 of <4[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

I-BET762 carboxylic acid Related Antibodies
Molecular Weight

396.83

Formula

C20H17ClN4O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC1=NN=C2[C@H](CC(O)=O)N=C(C3=CC=C(Cl)C=C3)C4=C(C=CC(OC)=C4)N21
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (503.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5200 mL 12.5999 mL 25.1997 mL
5 mM 0.5040 mL 2.5200 mL 5.0399 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.20%

COA (266 KB) LCMS (86 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5200 mL 12.5999 mL 25.1997 mL 62.9993 mL
5 mM 0.5040 mL 2.5200 mL 5.0399 mL 12.5999 mL
10 mM 0.2520 mL 1.2600 mL 2.5200 mL 6.2999 mL
15 mM 0.1680 mL 0.8400 mL 1.6800 mL 4.2000 mL
20 mM 0.1260 mL 0.6300 mL 1.2600 mL 3.1500 mL
25 mM 0.1008 mL 0.5040 mL 1.0080 mL 2.5200 mL
30 mM 0.0840 mL 0.4200 mL 0.8400 mL 2.1000 mL
40 mM 0.0630 mL 0.3150 mL 0.6300 mL 1.5750 mL
50 mM 0.0504 mL 0.2520 mL 0.5040 mL 1.2600 mL
60 mM 0.0420 mL 0.2100 mL 0.4200 mL 1.0500 mL
80 mM 0.0315 mL 0.1575 mL 0.3150 mL 0.7875 mL
100 mM 0.0252 mL 0.1260 mL 0.2520 mL 0.6300 mL
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I-BET762 carboxylic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

I-BET762 carboxylic acid1300019-38-8Molibresib carboxylic acid GSK525762A carboxylic acid PROTAC BRD4-binding moiety 2Ligands for Target Protein for PROTACEpigenetic Reader DomainTarget Protein-binding MoietyInhibitorinhibitorinhibit

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