2. GPCR/G Protein Immunology/Inflammation
  3. CXCR
  4. (R,R)-CXCR2-IN-2

(R,R)-CXCR2-IN-2, diastereoisomer of CXCR2-IN-2 (compound 68), is a brain penetrant CXCR2 antagonist with a pIC50 of 9 and 6.8 in the Tango assay and d in the HWB Gro-α induced CD11b expression assay, respectively.

For research use only. We do not sell to patients.

(R,R)-CXCR2-IN-2 Chemical Structure

(R,R)-CXCR2-IN-2 Chemical Structure

CAS No. : 1838123-22-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 468 In-stock
Solution
10 mM * 1 mL in DMSO USD 468 In-stock
Solid
5 mg USD 425 In-stock
10 mg USD 680 In-stock
25 mg USD 1300 In-stock
50 mg USD 2100 In-stock
100 mg USD 3300 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (R,R)-CXCR2-IN-2:

(R,R)-CXCR2-IN-2 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

(R,R)-CXCR2-IN-2, diastereoisomer of CXCR2-IN-2 (compound 68), is a brain penetrant CXCR2 antagonist with a pIC50 of 9 and 6.8 in the Tango assay and d in the HWB Gro-α induced CD11b expression assay, respectively[1].

Molecular Weight

414.90

Formula

C18H23ClN2O5S
CAS No.
Appearance

Solid

Color

Off-white to light brown

SMILES

O=S(C1=C(C(NC(N[C@H]2C(C)=CCC2)=O)=CC=C1Cl)O)([C@@]3(CCOC3)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 220 mg/mL (530.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4102 mL 12.0511 mL 24.1022 mL
5 mM 0.4820 mL 2.4102 mL 4.8204 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 5.5 mg/mL (13.26 mM); Clear solution

    This protocol yields a clear solution of ≥ 5.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (55.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.37% ee.: 99.84%

SDS (251 KB)

COA (251 KB) HNMR (239 KB) NP-HPLC (632 KB) LCMS (139 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4102 mL 12.0511 mL 24.1022 mL 60.2555 mL
5 mM 0.4820 mL 2.4102 mL 4.8204 mL 12.0511 mL
10 mM 0.2410 mL 1.2051 mL 2.4102 mL 6.0255 mL
15 mM 0.1607 mL 0.8034 mL 1.6068 mL 4.0170 mL
20 mM 0.1205 mL 0.6026 mL 1.2051 mL 3.0128 mL
25 mM 0.0964 mL 0.4820 mL 0.9641 mL 2.4102 mL
30 mM 0.0803 mL 0.4017 mL 0.8034 mL 2.0085 mL
40 mM 0.0603 mL 0.3013 mL 0.6026 mL 1.5064 mL
50 mM 0.0482 mL 0.2410 mL 0.4820 mL 1.2051 mL
60 mM 0.0402 mL 0.2009 mL 0.4017 mL 1.0043 mL
80 mM 0.0301 mL 0.1506 mL 0.3013 mL 0.7532 mL
100 mM 0.0241 mL 0.1205 mL 0.2410 mL 0.6026 mL
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(R,R)-CXCR2-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R,R)-CXCR2-IN-21838123-22-0CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsdiastereoisomerbrainpenetrantInhibitorinhibitorinhibit

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