2. Epigenetics TGF-beta/Smad Cytoskeleton Cell Cycle/DNA Damage Stem Cell/Wnt
  3. PKC ROCK
  4. (rac)-AR-13503

(rac)-AR-13503  (Synonyms: (rac)-AR-13324 M1 metabolite)

Cat. No.: HY-125639
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(rac)-AR-13503 ((rac)-AR-13324 M1 metabolite) is the isoform of AR-13503 (HY-12798C). AR-13503 a ROCK/PKC inhibitor, inhibiting angiogenesis and enhancing retinal pigment epithelium (RPE) permeability. AR-13503 also inhibits the formation of aberrant neovascularization (NV) in oxygen-induced retinopathy (OIR) model in mice.

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(rac)-AR-13503 Chemical Structure

(rac)-AR-13503 Chemical Structure

CAS No. : 1254032-16-0

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Other Forms of (rac)-AR-13503:

(rac)-AR-13503 Related Antibodies

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

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Description

(rac)-AR-13503 ((rac)-AR-13324 M1 metabolite) is the isoform of AR-13503 (HY-12798C). AR-13503 a ROCK/PKC inhibitor, inhibiting angiogenesis and enhancing retinal pigment epithelium (RPE) permeability. AR-13503 also inhibits the formation of aberrant neovascularization (NV) in oxygen-induced retinopathy (OIR) model in mice[1][2].

In Vitro

AR-13503 (16 h) inhibits human umbilical vein endothelial cell (HUVEC) tube formation, with an IC50 value of 21 nM[1].
AR-13503 (400 nM; 5 d) decreases the sprouting area of the choroidal in a dose-dependent manner[1].
AR-13503 (400 nM; 2 weeks) enhances primary porcine RPE barrier function in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(rac)-AR-13503 Related Antibodies
In Vivo

AR-13503 (1.25 mg/kg; i.p.; once daily for 5 days) in collaboration with Aflibercept (HY-108801), significantly decreases the development of aberrant neovascularization (NV)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Oxygen-induced retinopathy (OIR) mice model (C57BL/6; 7-days-old)[1]
Dosage: 1.25 mg/kg
Administration: Intraperitoneal injection; once daily for 5 days
Result: The combination group had a greater (~75%) reduction in NV than Aflibercept alone (~55%).
Clinical Trial
Molecular Weight

321.37

Formula

C19H19N3O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C(CN)C1=CC=C(CO)C=C1)NC2=CC3=C(C=C2)C=NC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(rac)-AR-13503 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(rac)-AR-135031254032-16-0(rac)-AR-13324 M1 metabolitePKCROCKProtein kinase CRho-associated protein kinaseRho-associated kinaseRho-kinaseROKInhibitorinhibitorinhibit

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