LRRC15 Protein, Cynomolgus (HEK293, His)

LRRC15 is a cell membrane-expressed protein belonging to the LRR superfamily. Involved in cell-cell and cell-ECM interactions. The LRRC15 protein regulates the infectivity of SARS-CoV-2 by interacting with its spike protein. LRRC15 activates the β1-integrin /FAK signaling pathway to promote ovarian cancer metastasis. LRRC15 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived LRRC15 protein, expressed by HEK293 , with C-His labeled tag. The total length of LRRC15 Protein, Cynomolgus (HEK293, His) is 517 a.a., with molecular weight of 70-80 kDa.

LRRC15 is a cell membrane-expressed protein belonging to the LRR superfamily. Involved in cell-cell and cell-ECM interactions. The LRRC15 protein regulates the infectivity of SARS-CoV-2 by interacting with its spike protein. It does not act as an entry receptor for SARS-CoV-2, but when it is expressed on nearby cells, it isolates virions and trans inhibits SARS-CoV-2 infection of ACE2 (+) cells. In addition, the LRRC15 protein directly interacts with the RBD domain of the human coronavirus SARS-CoV-2 spike protein, resulting in the isolation of virions on the cell surface. LRRC15 activates the β1-integrin /FAK signaling pathway to promote ovarian cancer metastasis, and the LRRC15-targeted antiboy-drug conjugate ABBV-085 was found to inhibit ovarian cancer metastasis in preclinical models^[1][2][3].

Cynomolgus

HEK293

C-His

A0A2K5UKB6 (Y22-G538)

102144360  [NCBI]

70-80 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.