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  3. LRRC15 Protein, Cynomolgus (HEK293, His)

LRRC15 Protein, Cynomolgus (HEK293, His)

Cat. No.: HY-P700892
Handling Instructions

LRRC15 is a cell membrane-expressed protein belonging to the LRR superfamily. Involved in cell-cell and cell-ECM interactions. The LRRC15 protein regulates the infectivity of SARS-CoV-2 by interacting with its spike protein. LRRC15 activates the β1-integrin /FAK signaling pathway to promote ovarian cancer metastasis. LRRC15 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived LRRC15 protein, expressed by HEK293 , with C-His labeled tag. The total length of LRRC15 Protein, Cynomolgus (HEK293, His) is 517 a.a., with molecular weight of 70-80 kDa.

For research use only. We do not sell to patients.

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Description

LRRC15 is a cell membrane-expressed protein belonging to the LRR superfamily. Involved in cell-cell and cell-ECM interactions. The LRRC15 protein regulates the infectivity of SARS-CoV-2 by interacting with its spike protein. LRRC15 activates the β1-integrin /FAK signaling pathway to promote ovarian cancer metastasis. LRRC15 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived LRRC15 protein, expressed by HEK293 , with C-His labeled tag. The total length of LRRC15 Protein, Cynomolgus (HEK293, His) is 517 a.a., with molecular weight of 70-80 kDa.

Background

LRRC15 is a cell membrane-expressed protein belonging to the LRR superfamily. Involved in cell-cell and cell-ECM interactions. The LRRC15 protein regulates the infectivity of SARS-CoV-2 by interacting with its spike protein. It does not act as an entry receptor for SARS-CoV-2, but when it is expressed on nearby cells, it isolates virions and trans inhibits SARS-CoV-2 infection of ACE2 (+) cells. In addition, the LRRC15 protein directly interacts with the RBD domain of the human coronavirus SARS-CoV-2 spike protein, resulting in the isolation of virions on the cell surface. LRRC15 activates the β1-integrin /FAK signaling pathway to promote ovarian cancer metastasis, and the LRRC15-targeted antiboy-drug conjugate ABBV-085 was found to inhibit ovarian cancer metastasis in preclinical models[1][2][3].

Species

Cynomolgus

Source

HEK293

Tag

C-His

Accession

A0A2K5UKB6 (Y22-G538)

Gene ID
Molecular Construction
N-term
LRRC15 (Y22-G538)
Accession # A0A2K5UKB6
His
C-term
Synonyms
LIB; LRRC15; EGM_11224
Molecular Weight

70-80 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

LRRC15 Protein, Cynomolgus (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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LRRC15 Protein, Cynomolgus (HEK293, His)
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HY-P700892
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