2. Anti-infection
  3. Antibiotic Bacterial
  4. Rifapentine

Rifapentine  (Synonyms: DL 473; Cyclopentylrifampicin)

Cat. No.: HY-B0269 Purity: ≥98.0%
COA Handling Instructions

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Rifapentine (DL 473) is an antibiotic used in tuberculosis research.

For research use only. We do not sell to patients.

Rifapentine Chemical Structure

Rifapentine Chemical Structure

CAS No. : 61379-65-5

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 85 In-stock
Solution
10 mM * 1 mL in DMSO USD 85 In-stock
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50 mg USD 77 In-stock
100 mg USD 132 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Rifapentine:

Rifapentine Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Rifapentine

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Rifapentine (DL 473) is an antibiotic used in tuberculosis research[1].

In Vitro

Rifapentine shows antibacterial activity against clinical staphylococci, with MICs ranging from 0.002 to >10 μg/mL (MIC90 values of 1.28 μg/mL for MSSA and MSSE, and ≥10 μg/mL for MRSA and MRSE)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Rifapentine Related Antibodies
In Vivo

Rifapentine (20 mg/kg, i.p., daily for five days followed by twice weekly for three weeks) reduces bacteria burden in the organs of a mouse model of disseminated Mycobacterium avium infection[2].
Rifapentine (a single dose of 30 mg/kg, i.v.) shows a plasma Cmax, T1/2 and AUC0-15 were 33 µg/mL (0.5 h), 4 h and 170 µg h/mL in rabbits. In lung tissue, the Cmax, T1/2 and AUC0-15 are 13 µg/mL (2 h), 6.7 h and 82 µg h/mL[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

877.03

Formula

C47H64N4O12
CAS No.
Appearance

Solid

Color

Pink to red

SMILES

OC(C1=C(C2=O)C(O[C@@]2(O/C=C/[C@@H]([C@H]([C@@]([C@@H]3C)([H])OC(C)=O)C)OC)C)=C(C)C(O)=C1C(O)=C4NC(/C(C)=C\C=C\[C@@H]([C@@H]([C@@H](C)[C@H]3O)O)C)=O)=C4/C=N/N5CCN(C6CCCC6)CC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (57.01 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1402 mL 5.7011 mL 11.4021 mL
5 mM 0.2280 mL 1.1402 mL 2.2804 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (2.85 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1402 mL 5.7011 mL 11.4021 mL 28.5053 mL
5 mM 0.2280 mL 1.1402 mL 2.2804 mL 5.7011 mL
10 mM 0.1140 mL 0.5701 mL 1.1402 mL 2.8505 mL
15 mM 0.0760 mL 0.3801 mL 0.7601 mL 1.9004 mL
20 mM 0.0570 mL 0.2851 mL 0.5701 mL 1.4253 mL
25 mM 0.0456 mL 0.2280 mL 0.4561 mL 1.1402 mL
30 mM 0.0380 mL 0.1900 mL 0.3801 mL 0.9502 mL
40 mM 0.0285 mL 0.1425 mL 0.2851 mL 0.7126 mL
50 mM 0.0228 mL 0.1140 mL 0.2280 mL 0.5701 mL
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Rifapentine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rifapentine61379-65-5DL 473 CyclopentylrifampicinDL473DL-473AntibioticBacterialstaphylococciantibacterialinfectionInhibitorinhibitorinhibit

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