Ritlecitinib tosylate (Synonyms: PF-06651600 tosylate)

Cat. No.: HY-100754C Purity: 99.77%: FAQs
Data Sheet SDS COA Handling Instructions

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Ritlecitinib tosylate is an orally active and selective JAK3 inhibitor with an IC₅₀ of 33.1 nM. Ritlecitinib tosylate is used for inflammatory and autoimmune diseases research.

For research use only. We do not sell to patients.

Ritlecitinib tosylate Chemical Structure

CAS No. : 2192215-81-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 70	In-stock	Estimated Time of Arrival: December 31
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10 mM * 1 mL in DMSO	USD 70	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 64	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 89	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 205	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 392	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 548	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of Ritlecitinib tosylate:

5 Publications Citing Use of MCE Ritlecitinib tosylate

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JAK1 JAK2 JAK3 Tyk2 JAK

Biological Activity
Purity & Documentation
References
Customer Review

Description

Ritlecitinib tosylate is an orally active and selective JAK3 inhibitor with an IC₅₀ of 33.1 nM. Ritlecitinib tosylate is used for inflammatory and autoimmune diseases research^[1].

Molecular Weight

457.55

Formula

C₂₂H₂₇N₅O₄S

CAS No.

2192215-81-7

Appearance

Solid

Color

White to off-white

SMILES

CC(C=C1)=CC=C1S(O)(=O)=O.C=CC(N2[C@@H](C)CC[C@@H](NC3=C4C(NC=C4)=NC=N3)C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 83.33 mg/mL (182.12 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1856 mL	10.9278 mL	21.8555 mL
5 mM	0.4371 mL	2.1856 mL	4.3711 mL
10 mM	0.2186 mL	1.0928 mL	2.1856 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.77%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (249 KB) HNMR (305 KB) LCMS (98 KB)

Handling Instructions (2659 KB)

References

[1]. Telliez JB, et al. Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition. ACS Chem Biol. 2016 Dec 16;11(12):3442-3451. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1856 mL	10.9278 mL	21.8555 mL	54.6388 mL
	5 mM	0.4371 mL	2.1856 mL	4.3711 mL	10.9278 mL
	10 mM	0.2186 mL	1.0928 mL	2.1856 mL	5.4639 mL
	15 mM	0.1457 mL	0.7285 mL	1.4570 mL	3.6426 mL
	20 mM	0.1093 mL	0.5464 mL	1.0928 mL	2.7319 mL
	25 mM	0.0874 mL	0.4371 mL	0.8742 mL	2.1856 mL
	30 mM	0.0729 mL	0.3643 mL	0.7285 mL	1.8213 mL
	40 mM	0.0546 mL	0.2732 mL	0.5464 mL	1.3660 mL
	50 mM	0.0437 mL	0.2186 mL	0.4371 mL	1.0928 mL
	60 mM	0.0364 mL	0.1821 mL	0.3643 mL	0.9106 mL
	80 mM	0.0273 mL	0.1366 mL	0.2732 mL	0.6830 mL
	100 mM	0.0219 mL	0.1093 mL	0.2186 mL	0.5464 mL

Ritlecitinib tosylate Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ritlecitinib2192215-81-7PF-06651600PF06651600PF 06651600JAKJanus kinaseInhibitorinhibitorinhibit

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Ritlecitinib tosylate (Synonyms: PF-06651600 tosylate)

Customer Review

Other Forms of Ritlecitinib tosylate:

Ritlecitinib tosylate Related Antibodies

5 Publications Citing Use of MCE Ritlecitinib tosylate

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All JAK Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Ritlecitinib tosylate Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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