RNF114 ligand 1

Cat. No.: HY-156499 Purity: ≥95.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

RNF114 ligand 1 is a E3 Ubiquitin ligase binder.

For research use only. We do not sell to patients.

RNF114 ligand 1 Chemical Structure

CAS No. : 900137-36-2

Size	Price	Stock	Quantity
5 mg	USD 145	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 230	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Purity & Documentation
References
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Description

RNF114 ligand 1 is a E3 Ubiquitin ligase binder^[1].

Molecular Weight

283.75

Formula

C₁₄H₁₈ClNO₃

CAS No.

900137-36-2

Appearance

Solid

Color

Gray to dark gray

SMILES

O=C(CCl)N1CCCC1C2=CC(OC)=CC=C2OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (352.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5242 mL	17.6211 mL	35.2423 mL
5 mM	0.7048 mL	3.5242 mL	7.0485 mL
10 mM	0.3524 mL	1.7621 mL	3.5242 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.81 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (273 KB) SDS (555 KB)

COA (256 KB)

Handling Instructions (2659 KB)

References

[1]. Jessica S, ta al. Covalent targeting of e3 ligases. The US, WO2020076996A1. 2019-10-09.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5242 mL	17.6211 mL	35.2423 mL	88.1057 mL
	5 mM	0.7048 mL	3.5242 mL	7.0485 mL	17.6211 mL
	10 mM	0.3524 mL	1.7621 mL	3.5242 mL	8.8106 mL
	15 mM	0.2349 mL	1.1747 mL	2.3495 mL	5.8737 mL
	20 mM	0.1762 mL	0.8811 mL	1.7621 mL	4.4053 mL
	25 mM	0.1410 mL	0.7048 mL	1.4097 mL	3.5242 mL
	30 mM	0.1175 mL	0.5874 mL	1.1747 mL	2.9369 mL
	40 mM	0.0881 mL	0.4405 mL	0.8811 mL	2.2026 mL
	50 mM	0.0705 mL	0.3524 mL	0.7048 mL	1.7621 mL
	60 mM	0.0587 mL	0.2937 mL	0.5874 mL	1.4684 mL
	80 mM	0.0441 mL	0.2203 mL	0.4405 mL	1.1013 mL
	100 mM	0.0352 mL	0.1762 mL	0.3524 mL	0.8811 mL

RNF114 ligand 1 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RNF114 ligand 1900137-36-2OthersE3 ligasesRNF114protein degraderInhibitorinhibitorinhibit

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