2. Anti-infection
  3. Bacterial
  4. Ro 25-0534

Ro 25-0534 is an antimicrobial compound against Pseudomonas. Ro 25-0534 is active against Enterobacteriaceae (MIC90: 0.06-2 μg/mL), Oxacillin (HY-B0465)-susceptible staphylococci, β-hemolytic streptococci, and penicillin-susceptible pneumococci (MIC90: 1-2 μg/mL), Haemophilus influenzae (MIC90: 0.25-0.5 μg/mL), Moraxella catarrhalis (MIC90: 0.5 μg/mL), and most nonenteric Gram-negative bacilli (MIC90: 2-4 μg/mL).

For research use only. We do not sell to patients.

Ro 25-0534 Chemical Structure

Ro 25-0534 Chemical Structure

CAS No. : 143488-32-8

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Based on 1 publication(s) in Google Scholar

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Description

Ro 25-0534 is an antimicrobial compound against Pseudomonas. Ro 25-0534 is active against Enterobacteriaceae (MIC90: 0.06-2 μg/mL), Oxacillin (HY-B0465)-susceptible staphylococci, β-hemolytic streptococci, and penicillin-susceptible pneumococci (MIC90: 1-2 μg/mL), Haemophilus influenzae (MIC90: 0.25-0.5 μg/mL), Moraxella catarrhalis (MIC90: 0.5 μg/mL), and most nonenteric Gram-negative bacilli (MIC90: 2-4 μg/mL)[1].

Molecular Weight

948.95

Formula

C41H41FN10O12S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(C1=C(CN2CCN(C(C=C3N(C4CC4)C=C5C(O)=O)=C(F)C=C3C5=O)CC2)CS[C@@]([C@@H]6NC(/C(C7=CSC(N)=N7)=N\OC(C)(C)C(NNC(C8=CC(O)=C(C=C8)O)=O)=O)=O)([H])N1C6=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (105.38 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0538 mL 5.2690 mL 10.5380 mL
5 mM 0.2108 mL 1.0538 mL 2.1076 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0538 mL 5.2690 mL 10.5380 mL 26.3449 mL
5 mM 0.2108 mL 1.0538 mL 2.1076 mL 5.2690 mL
10 mM 0.1054 mL 0.5269 mL 1.0538 mL 2.6345 mL
15 mM 0.0703 mL 0.3513 mL 0.7025 mL 1.7563 mL
20 mM 0.0527 mL 0.2634 mL 0.5269 mL 1.3172 mL
25 mM 0.0422 mL 0.2108 mL 0.4215 mL 1.0538 mL
30 mM 0.0351 mL 0.1756 mL 0.3513 mL 0.8782 mL
40 mM 0.0263 mL 0.1317 mL 0.2634 mL 0.6586 mL
50 mM 0.0211 mL 0.1054 mL 0.2108 mL 0.5269 mL
60 mM 0.0176 mL 0.0878 mL 0.1756 mL 0.4391 mL
80 mM 0.0132 mL 0.0659 mL 0.1317 mL 0.3293 mL
100 mM 0.0105 mL 0.0527 mL 0.1054 mL 0.2634 mL
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Ro 25-0534 Related Classifications

Keywords:

Ro 25-0534143488-32-8BacterialInhibitorinhibitorinhibit

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