2. NF-κB
  3. NF-κB
  4. Rubipodanone A

Rubipodanone A, a naphthohydroquinone dimer, shows cytotoxicity against A549, BEL-7402, HeLa, HepG2, SGC-7901 and U251 cells. Rubipodanone A also shows obvious activating effect at 20 and 40 μM for NF-κB.

For research use only. We do not sell to patients.

Rubipodanone A Chemical Structure

Rubipodanone A Chemical Structure

CAS No. : 2170211-22-8

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Based on 1 publication(s) in Google Scholar

Rubipodanone A Related Antibodies

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Description

Rubipodanone A, a naphthohydroquinone dimer, shows cytotoxicity against A549, BEL-7402, HeLa, HepG2, SGC-7901 and U251 cells. Rubipodanone A also shows obvious activating effect at 20 and 40 μM for NF-κB[1].

In Vitro

Rubipodanone A shows cytotoxicity against A549, BEL-7402, HeLa, HepG2, SGC-7901 and U251 cells (IC50=16.77-31.89 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Rubipodanone A Related Antibodies
Molecular Weight

442.46

Formula

C27H22O6
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

C/C(C)=C\C[C@@](C(C1=CC=CC=C21)=O)(C(C(C3=CC=CC=C34)=O)=CC4=O)C(C(OC)=O)=C2O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (22.60 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2601 mL 11.3005 mL 22.6009 mL
5 mM 0.4520 mL 2.2601 mL 4.5202 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.40%

SDS (252 KB)

COA (260 KB) HNMR (491 KB) CNMR (532 KB) RP-HPLC (871 KB) MS (345 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2601 mL 11.3005 mL 22.6009 mL 56.5023 mL
5 mM 0.4520 mL 2.2601 mL 4.5202 mL 11.3005 mL
10 mM 0.2260 mL 1.1300 mL 2.2601 mL 5.6502 mL
15 mM 0.1507 mL 0.7534 mL 1.5067 mL 3.7668 mL
20 mM 0.1130 mL 0.5650 mL 1.1300 mL 2.8251 mL
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Rubipodanone A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rubipodanone A2170211-22-8NF-κBNuclear factor-κBNuclear factor-kappaBnaphthohydroquinonedimercytotoxicityA549BEL-7402HeLaHepG2SGC-7901U251cellsInhibitorinhibitorinhibit

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