2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor Dopamine Receptor
  4. S-14506 hydrochloride

S-14506 hydrochloride is a potent 5-HT1A agonist, as well as 5-HT2A/2C antagonist. S-14506 hydrochloride displays dopamine antagonist properties by blocking dopamine D2 receptors. S-14506 hydrochloride inhibits the in vivo binding of [3H]raclopride in striatum and olfactory bulbs. S-14506 hydrochloride has the potential for the research of anxiolytic agent.

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S-14506 hydrochloride Chemical Structure

S-14506 hydrochloride Chemical Structure

CAS No. : 286369-38-8

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Based on 1 publication(s) in Google Scholar

Other Forms of S-14506 hydrochloride:

S-14506 hydrochloride Related Antibodies

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Description

S-14506 hydrochloride is a potent 5-HT1A agonist, as well as 5-HT2A/2C antagonist. S-14506 hydrochloride displays dopamine antagonist properties by blocking dopamine D2 receptors. S-14506 hydrochloride inhibits the in vivo binding of [3H]raclopride in striatum and olfactory bulbs. S-14506 hydrochloride has the potential for the research of anxiolytic agent[1][2][3].

IC50 & Target[2][3]

5-HT1 Receptor

 

5-HT2A Receptor

 

5-HT2C Receptor

 

D2 Receptor

 

In Vitro

S-14506 hydrochloride serves as 5-HT1A receptor agonist, appearing to be G(i) protein-dependent[4].
S-14506 hydrochloride (0.1 nM-100 μM; 10 min) shows high affinity for the G protein-uncoupled state of the 5-HT receptor in HeLa cells with pertussis toxin treatment[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

S-14506 hydrochloride Related Antibodies
In Vivo

S-14506 hydrochloride (0.2-3.38 mg/kg; IP; single dose) dose dependently antagonizes Apomorphine (0.75 mg/kg, s.c.) induced stereotyped climbing and sniffing in mice. S-14506 hydrochloride displays dopamine antagonist properties by blocking dopamine D2 receptors[2].
S-14506 hydrochloride (0.63 mg/kg; SC; single dose) is active in forced swimming test in rats. It induces imobility in rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male swiss albino mice (25-30 g) and male Wistar rats (170-230 g)[2]
Dosage: 0.2 mg/kg, 0.8 mg/kg, 3.2 mg/kg, 3.8 mg/kg
Administration: IP; single dose, 30 min before test
Result: Inhibited stereotyped climbing and sniffing behaviours induced by dopamine agonists in mice and on spontaneous behaviours.
Animal Model: Male Wistar rats (200-220 g)[3]
Dosage: 0.01 mg/kg, 0.63 mg/kg
Administration: SC; and gave antagonist 30 min after agonist
Result: Induced a dose-dependent imobility in rats.
Molecular Weight

443.94

Formula

C24H27ClFN3O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(C=C1)F)NCCN2CCN(CC2)C3=C4C=C(C=CC4=CC=C3)OC.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (563.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2526 mL 11.2628 mL 22.5256 mL
5 mM 0.4505 mL 2.2526 mL 4.5051 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2526 mL 11.2628 mL 22.5256 mL 56.3139 mL
5 mM 0.4505 mL 2.2526 mL 4.5051 mL 11.2628 mL
10 mM 0.2253 mL 1.1263 mL 2.2526 mL 5.6314 mL
15 mM 0.1502 mL 0.7509 mL 1.5017 mL 3.7543 mL
20 mM 0.1126 mL 0.5631 mL 1.1263 mL 2.8157 mL
25 mM 0.0901 mL 0.4505 mL 0.9010 mL 2.2526 mL
30 mM 0.0751 mL 0.3754 mL 0.7509 mL 1.8771 mL
40 mM 0.0563 mL 0.2816 mL 0.5631 mL 1.4078 mL
50 mM 0.0451 mL 0.2253 mL 0.4505 mL 1.1263 mL
60 mM 0.0375 mL 0.1877 mL 0.3754 mL 0.9386 mL
80 mM 0.0282 mL 0.1408 mL 0.2816 mL 0.7039 mL
100 mM 0.0225 mL 0.1126 mL 0.2253 mL 0.5631 mL
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S-14506 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S-14506286369-38-8S14506S 145065-HT ReceptorDopamine ReceptorSerotonin Receptor5-hydroxytryptamine Receptordopamine D2[3H]racloprideanxiolytic agentInhibitorinhibitorinhibit

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