S 17092 (Synonyms: S 17092-1)

Cat. No.: HY-15114 Purity: 98.42%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

S 17092 (S 17092-1) is a potent cerebral prolyl-endopeptidase (PEP) inhibitor with an IC₅₀ of 1.2 nM. S 17092 can be used for the research of memory impairment and cognitive disorders associated with cerebral aging.

For research use only. We do not sell to patients.

S 17092 Chemical Structure

CAS No. : 176797-26-5

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 182	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 182	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 165	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 290	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 620	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1060	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1800	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Description

Molecular Weight

384.53

Formula

C₂₂H₂₈N₂O₂S

CAS No.

176797-26-5

Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H]1[C@@](C2=CC=CC=C2)([H])C1)N3[C@]4([H])[C@](CCCC4)([H])C[C@H]3C(N5CCSC5)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (260.06 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6006 mL	13.0029 mL	26.0058 mL
5 mM	0.5201 mL	2.6006 mL	5.2012 mL
10 mM	0.2601 mL	1.3003 mL	2.6006 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.42%

Select Batch:

Data Sheet (277 KB) SDS (392 KB)

COA (259 KB) HNMR (144 KB) RP-HPLC (175 KB)

Handling Instructions (2659 KB)

References

[1]. Philippe Morain, et al. S 17092: a prolyl endopeptidase inhibitor as a potential therapeutic drug for memory impairment. Preclinical and clinical studies. CNS Drug Rev. Spring 2002;8(1):31-52. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6006 mL	13.0029 mL	26.0058 mL	65.0144 mL
	5 mM	0.5201 mL	2.6006 mL	5.2012 mL	13.0029 mL
	10 mM	0.2601 mL	1.3003 mL	2.6006 mL	6.5014 mL
	15 mM	0.1734 mL	0.8669 mL	1.7337 mL	4.3343 mL
	20 mM	0.1300 mL	0.6501 mL	1.3003 mL	3.2507 mL
	25 mM	0.1040 mL	0.5201 mL	1.0402 mL	2.6006 mL
	30 mM	0.0867 mL	0.4334 mL	0.8669 mL	2.1671 mL
	40 mM	0.0650 mL	0.3251 mL	0.6501 mL	1.6254 mL
	50 mM	0.0520 mL	0.2601 mL	0.5201 mL	1.3003 mL
	60 mM	0.0433 mL	0.2167 mL	0.4334 mL	1.0836 mL
	80 mM	0.0325 mL	0.1625 mL	0.3251 mL	0.8127 mL
	100 mM	0.0260 mL	0.1300 mL	0.2601 mL	0.6501 mL

S 17092 Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S 17092176797-26-5S 17092-1S17092S-17092Prolyl Endopeptidase (PREP)prolyl oligopeptidasePOPMemory enhancerProlyl endopeptidase inhibitorCognitive disordersNeuropeptidesNeuroprotectionCerebral agingInhibitorinhibitorinhibit

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S 17092 (Synonyms: S 17092-1)

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Complete Stock Solution Preparation Table

S 17092 Related Classifications

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