2. Metabolic Enzyme/Protease
  3. Prolyl Endopeptidase (PREP)
  4. S 17092

S 17092 (S 17092-1) is a potent cerebral prolyl-endopeptidase (PEP) inhibitor with an IC50 of 1.2 nM. S 17092 can be used for the research of memory impairment and cognitive disorders associated with cerebral aging.

For research use only. We do not sell to patients.

S 17092 Chemical Structure

S 17092 Chemical Structure

CAS No. : 176797-26-5

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10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 182 In-stock
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5 mg USD 165 In-stock
10 mg USD 290 In-stock
25 mg USD 620 In-stock
50 mg USD 1060 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

S 17092 (S 17092-1) is a potent cerebral prolyl-endopeptidase (PEP) inhibitor with an IC50 of 1.2 nM. S 17092 can be used for the research of memory impairment and cognitive disorders associated with cerebral aging[1].

Molecular Weight

384.53

Formula

C22H28N2O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H]1[C@@](C2=CC=CC=C2)([H])C1)N3[C@]4([H])[C@](CCCC4)([H])C[C@H]3C(N5CCSC5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (260.06 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6006 mL 13.0029 mL 26.0058 mL
5 mM 0.5201 mL 2.6006 mL 5.2012 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6006 mL 13.0029 mL 26.0058 mL 65.0144 mL
5 mM 0.5201 mL 2.6006 mL 5.2012 mL 13.0029 mL
10 mM 0.2601 mL 1.3003 mL 2.6006 mL 6.5014 mL
15 mM 0.1734 mL 0.8669 mL 1.7337 mL 4.3343 mL
20 mM 0.1300 mL 0.6501 mL 1.3003 mL 3.2507 mL
25 mM 0.1040 mL 0.5201 mL 1.0402 mL 2.6006 mL
30 mM 0.0867 mL 0.4334 mL 0.8669 mL 2.1671 mL
40 mM 0.0650 mL 0.3251 mL 0.6501 mL 1.6254 mL
50 mM 0.0520 mL 0.2601 mL 0.5201 mL 1.3003 mL
60 mM 0.0433 mL 0.2167 mL 0.4334 mL 1.0836 mL
80 mM 0.0325 mL 0.1625 mL 0.3251 mL 0.8127 mL
100 mM 0.0260 mL 0.1300 mL 0.2601 mL 0.6501 mL
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S 17092 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S 17092176797-26-5S 17092-1S17092S-17092Prolyl Endopeptidase (PREP)prolyl oligopeptidasePOPMemory enhancerProlyl endopeptidase inhibitorCognitive disordersNeuropeptidesNeuroprotectionCerebral agingInhibitorinhibitorinhibit

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