2. Membrane Transporter/Ion Channel Neuronal Signaling
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  4. S 18986

S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors. S 18986 shows cognitive enhancing properties in rodents. S 18986 activates the release of noradrenaline and acetylcholine in rat hippocampus and enhances rat memory in object-recognition tests.

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S 18986 Chemical Structure

S 18986 Chemical Structure

CAS No. : 175340-20-2

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1 mg USD 40 In-stock
5 mg USD 130 In-stock
10 mg USD 210 In-stock
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50 mg USD 750 In-stock
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Based on 1 publication(s) in Google Scholar

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AMPA Receptor NMDA Receptor Kainate Receptor

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Description

S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors. S 18986 shows cognitive enhancing properties in rodents. S 18986 activates the release of noradrenaline and acetylcholine in rat hippocampus and enhances rat memory in object-recognition tests[1][2].

In Vivo

S 18986 is robust memory-enhancing effects in middle-aged animals compared with aged ones. S 18986 shows antiamnesic properties in middle-aged rodents in spatial memory models [1].
S 18986 (5-50 mg/kg; i.p.) significantly increases both the induction and the maintenance of 4 and 20 bursts tetanus-evoked potentiation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Middle-aged (14-15-months-old) mice[1]
Dosage: 0.3, 1, and 10 mg/kg
Administration: p.o.
Result: Showed antiamnesic properties in middle-aged rodents.
Clinical Trial
Molecular Weight

224.28

Formula

C10H12N2O2S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=S1(C2=CC=CC=C2N3[C@@](CCC3)([H])N1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (445.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4587 mL 22.2936 mL 44.5871 mL
5 mM 0.8917 mL 4.4587 mL 8.9174 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.24%

COA (259 KB) HNMR (120 KB) RP-HPLC (205 KB) LCMS (388 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.4587 mL 22.2936 mL 44.5871 mL 111.4678 mL
5 mM 0.8917 mL 4.4587 mL 8.9174 mL 22.2936 mL
10 mM 0.4459 mL 2.2294 mL 4.4587 mL 11.1468 mL
15 mM 0.2972 mL 1.4862 mL 2.9725 mL 7.4312 mL
20 mM 0.2229 mL 1.1147 mL 2.2294 mL 5.5734 mL
25 mM 0.1783 mL 0.8917 mL 1.7835 mL 4.4587 mL
30 mM 0.1486 mL 0.7431 mL 1.4862 mL 3.7156 mL
40 mM 0.1115 mL 0.5573 mL 1.1147 mL 2.7867 mL
50 mM 0.0892 mL 0.4459 mL 0.8917 mL 2.2294 mL
60 mM 0.0743 mL 0.3716 mL 0.7431 mL 1.8578 mL
80 mM 0.0557 mL 0.2787 mL 0.5573 mL 1.3933 mL
100 mM 0.0446 mL 0.2229 mL 0.4459 mL 1.1147 mL
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S 18986 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S 18986175340-20-2S18986S-18986iGluRIonotropic glutamate receptorsbrainpenetrantcognitiverodentsmemoryglutamateneuroprotectionantiamnesicInhibitorinhibitorinhibit

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