(S)-Seco-Duocarmycin SA

Cat. No.: HY-129356A Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

(S)-Seco-Duocarmycin SA is a DNA alkylator, cytotoxic to cancer cells, and acts as a ADC cytotoxin for antibody-drug conjugates.

For research use only. We do not sell to patients.

(S)-Seco-Duocarmycin SA Chemical Structure

CAS No. : 152785-82-5

Size	Price	Stock	Quantity
1 mg	USD 717	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1650	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (S)-Seco-Duocarmycin SA:

Seco-Duocarmycin SA Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

(S)-Seco-Duocarmycin SA is a DNA alkylator, cytotoxic to cancer cells, and acts as a ADC cytotoxin for antibody-drug conjugates^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
L1210	IC₅₀	0.008 nM Compound: seco-DSA	Cytotoxicity against mouse L1210 cells after 72 hrs by phosphatase assay Cytotoxicity against mouse L1210 cells after 72 hrs by phosphatase assay	[PMID: 23944748]

Molecular Weight

513.93

Formula

C₂₅H₂₄ClN₃O₇

CAS No.

152785-82-5

Appearance

Solid

Color

Light yellow to yellow

SMILES

ClC[C@H]1C2=C(C=C(O)C3=C2C=C(C(OC)=O)N3)N(C(C4=CC5=CC(OC)=C(OC)C(OC)=C5N4)=O)C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (194.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9458 mL	9.7290 mL	19.4579 mL
5 mM	0.3892 mL	1.9458 mL	3.8916 mL
10 mM	0.1946 mL	0.9729 mL	1.9458 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (268 KB) SDS (251 KB)

COA (248 KB) HNMR (176 KB)

Handling Instructions (2659 KB)

References

[1]. Tichenor MS, et al. Systematic exploration of the structural features of yatakemycin impacting DNA alkylation and biological activity. J Am Chem Soc. 2007 Sep 5;129(35):10858-69. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9458 mL	9.7290 mL	19.4579 mL	48.6448 mL
	5 mM	0.3892 mL	1.9458 mL	3.8916 mL	9.7290 mL
	10 mM	0.1946 mL	0.9729 mL	1.9458 mL	4.8645 mL
	15 mM	0.1297 mL	0.6486 mL	1.2972 mL	3.2430 mL
	20 mM	0.0973 mL	0.4864 mL	0.9729 mL	2.4322 mL
	25 mM	0.0778 mL	0.3892 mL	0.7783 mL	1.9458 mL
	30 mM	0.0649 mL	0.3243 mL	0.6486 mL	1.6215 mL
	40 mM	0.0486 mL	0.2432 mL	0.4864 mL	1.2161 mL
	50 mM	0.0389 mL	0.1946 mL	0.3892 mL	0.9729 mL
	60 mM	0.0324 mL	0.1621 mL	0.3243 mL	0.8107 mL
	80 mM	0.0243 mL	0.1216 mL	0.2432 mL	0.6081 mL
	100 mM	0.0195 mL	0.0973 mL	0.1946 mL	0.4864 mL