2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. SD-6

SD-6 is an orally active inhibitor of hAChE and hBChE with IC50 values of 0.907 µM and 1.579 µM, respectively. SD-6 has excellent blood-brain barrier (BBB) permeability and no neurotoxicity, which can be used for research on Alzheimer's disease.

For research use only. We do not sell to patients.

SD-6 Chemical Structure

SD-6 Chemical Structure

CAS No. : 744206-31-3

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Based on 1 publication(s) in Google Scholar

SD-6 Related Antibodies

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Description

SD-6 is an orally active inhibitor of hAChE and hBChE with IC50 values of 0.907 µM and 1.579 µM, respectively. SD-6 has excellent blood-brain barrier (BBB) permeability and no neurotoxicity, which can be used for research on Alzheimer's disease[1].

IC50 & Target[1]

hAChE

0.907 μM (IC50)

hBCHE

1.579 μM (IC50)

In Vitro

SD-6 (5-80 µM; 24 h) has neuroprotective effects in SH-SY5Y cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SD-6 Related Antibodies

Cell Viability Assay[1]

Cell Line: SH-SY5Y cells.
Concentration: 5, 10, 20, 40 or 80 µM.
Incubation Time: 24 h.
Result: Exhibited toxicity to differentiated SH-SY5Y cell lines and has a protective effect on undifferentiated SH-SY5Y cell lines.
In Vivo

SD-6 (100, 300 and 500 mg/kg; p.o.; single dose) has no toxic effect on nonpregnant female Wistar rats[1].
SD-6 (2.5, 5 and 10 mg/kg; p.o.; 3 times a day for 7 days) improves cognitive and memory deficits induced by Scopolamine (HY-N0296) in male Wistar rats[1].
SD-6 (2.5, 5 and 10 mg/kg; p.o.; single dose) significantly improves the abnormalities induced by Scopolamine in rats and promotes the normalization of biochemical indicators[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 10–11 weeks nonpregnant female Wistar rats (220–280 g)[1].
Dosage: 100, 300 and 500 mg/kg.
Administration: Oral gavage; single dose.
Result: Showed safety and tolerability.
Animal Model: 10–11 weeks male Wistar rats (220–280 g)[1].
Dosage: 2.5、5、10 mg/kg.
Administration: Oral gavage; 3 times a day for 7 days or single dose.
Result: Had the function of repairing cognitive and memory deficits.
Reduced the level of AChE and malonaldehyde (MDA), increased the level of acetylcholine, superoxide dismutase (SOD), glutathione (GSH) and catalase.
Molecular Weight

366.48

Formula

C20H22N4OS
CAS No.
SMILES

S=C1OC(C2=CC=CC=C2)=NN1CN3CCN(CC3)CC4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SD-6 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SD-6744206-31-3SD6SD 6Cholinesterase (ChE)Wistar ratsScopolamineSH-SY5Y cellsInhibitorinhibitorinhibit

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