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Results for "

3D7 P. falciparum

" in MedChemExpress (MCE) Product Catalog:

22

Inhibitors & Agonists

5

Natural
Products

2

Recombinant Proteins

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-117684
    Cabamiquine

    DDD107498; DDD-498; M5717

    		 Parasite CaMK Infection
    Cabamiquine (DDD107498) is a potent and orally active antimalarial agent, inhibits multiple life-cycle stages of the parasite, with an EC50 of 1 nM against P. falciparum 3D7. Cabamiquine inhibits protein synthesis by targeting eEF2/CaMKIII, with an EC50 of 2 nM for WT-PfeEF2 .
    Cabamiquine
  • HY-117684A
    Cabamiquine succinate

    DDD107498 succinate; DDD-498 succinate; M5717 succinate

    		 Parasite CaMK Infection
    Cabamiquine (DDD107498) succinate is a potent and orally active antimalarial agent, inhibits multiple life-cycle stages of the parasite, with an EC50 of 1 nM against P. falciparum 3D7. Cabamiquine succinate inhibits protein synthesis by targeting eEF2/CaMKIII, with an EC50 of 2 nM for WT-PfeEF2 .
    Cabamiquine succinate
  • HY-N0674A
    Dehydrocorydaline chloride
    Maximum Cited Publications
    27 Publications Verification

    13-Methylpalmatine chloride

    		 Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy Infection Cancer
    Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP . Dehydrocorydaline chloride elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities . Dehydrocorydaline chloride shows strong anti-malarial effects (IC50 =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .
    Dehydrocorydaline chloride
  • HY-N0674
    Dehydrocorydaline
    Maximum Cited Publications
    27 Publications Verification

    13-Methylpalmatine

    		 Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy Infection Cancer
    Dehydrocorydaline (13-Methylpalmatine) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP . Dehydrocorydaline elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities . Dehydrocorydaline shows strong anti-malarial effects (IC50=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .
    Dehydrocorydaline
  • HY-168184
    WJM280

    		Parasite Infection
    WJM280 is an orally active antimalarial agent, with an EC50 of 0.04 μM for P. falciparum 3D7 parasites .
    WJM280
  • HY-150065
    Antimalarial agent 15

    		Parasite Infection Inflammation/Immunology
    Antimalarial agent 15 (Compound 4e) is a parasite inhibitor. Antimalarial agent 15 shows antimalarial activity, and can inhibit P. falciparum 3D7 parasite growth (IC50=20 nM) .
    Antimalarial agent 15
  • HY-143487
    Antimalarial agent 12

    		Parasite Infection
    Antimalarial agent 12 (compound R-3b) is a potent antimalarial agent. Antimalarial agent 12 shows growth inhibition on P. falciparum Dd2 Strain (EC50=155 nM), 3D7 strain (EC50=136 nM). Antimalarial agent 12 has CC50 values of 10,000 to 50,000 nM for HEK-293 and hPHep cell lines. Antimalarial agent 12 has a MIC of >250,000 nM for Escherichia coli .
    Antimalarial agent 12
  • HY-128354
    CWHM-1552

    		Parasite Infection
    CWHM-1552 is an orally efficacious inhibitor of P. falciparum with IC50s of 51 nM and 53 nM for 3D7 and Dd2 strain, respectively .
    CWHM-1552
  • HY-149782
    Phosphodiesterase-IN-1

    		Phosphodiesterase (PDE) Parasite Infection
    Phosphodiesterase-IN-1 (Compound 7) is a phosphodiesterase (PDE) inhibitor with anti-Plasmodium activity. Phosphodiesterase-IN-1 has antiproliferative activity against P. falciparum (strain 3D7) with an IC50 value of 0.64 μM .
    Phosphodiesterase-IN-1
  • HY-147850
    JMI-346

    		Parasite Infection
    JMI-346 is a potent PfFP-2 (Plasmodium falciparum falcipain-2 protease) inhibitor. JMI-346 inhibits the growth of CQ S (3D7; IC50=13 µM) and CQ R (RKL-9; IC50=33 µM) strains of P. falciparum. JMI-346 has the potential to be used as an anti-malarial agent .
    JMI-346
  • HY-N0674B
    Dehydrocorydaline (hydroxyl)
    Maximum Cited Publications
    27 Publications Verification

    13-Methylpalmatine (hydroxyl)

    		 Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy Infection Inflammation/Immunology Cancer
    Dehydrocorydaline (13-Methylpalmatine) hydroxyl is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline hydroxyl elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. Dehydrocorydaline hydroxyl shows strong anti-malarial effects (IC50=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.
    Dehydrocorydaline (hydroxyl)
  • HY-135855
    SARS-CoV-IN-1
    1 Publications Verification

    		 SARS-CoV Parasite Infection
    SARS-CoV-IN-1 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-1 shows anti-Coronavirus activity with an EC50 of 4.9 μM in Vero cells. SARS-CoV-IN-1 inhibits the 3D7 and W2 strains of P. falciparum with IC50s of 15.4 and 133.2 nM; and IC90s of 25.7 and 459.1 nM; respectively. Antimalarial and antiviral activities .
    SARS-CoV-IN-1
  • HY-147849
    JMI-105

    		Parasite Infection
    JMI-105 is a potent PfFP-2 (Plasmodium falciparum falcipain-2 protease) inhibitor. JMI-105 inhibits the growth of CQ S (3D7; IC50=8.8 µM) and CQ R (RKL-9; IC50=14.3 µM) strains of P. falciparum. JMI-105 significantly decreases parasitemia and prolonged host survival in a murine model with P. berghei ANKA infection. JMI-105 has the potential to be used as an anti-malarial agent .
    JMI-105
  • HY-120462
    Genz-669178

    		Dihydroorotate Dehydrogenase Parasite Infection
    Genz-669178 is an inhibitor for dihydroorotate dehydrogenase (DHODH) with IC50 of 0.015-0.05 μM in Plasmodium spp.. Genz-669178 inhibits P. berghei, P. falciparum strains 3D7 and Dd2 with IC50 of 0.068, 0.008 and 0.01 μM, respectively. Genz-669178 exhibits anti-malarial efficacy in P. berghei-infected mice with ED50 of 13-21 mg/kg/day. Genz-669178 exhibits good pharmacokinetic characteristics in mice .
    Genz-669178
  • HY-134914
    Fosmidomycin

    		Antibiotic Parasite Infection
    Fosmidomycin is an orally active antibiotic, which exhibits antimalarial activity through inhibition of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DOXP reductoisomerase). Fosmidomycin inhibits P. falciparum strains 3D7, HB3, Dd2 and A2, with IC50s of 150, 71, 170 and 150 ng/mL, respectively. Fosmidomycin exhibits synergistic effect with Clindamycin (HY-B1455), and ameliorates malaria in mouse model .
    Fosmidomycin
  • HY-N4238
    Dehydrocorydaline nitrate
    Maximum Cited Publications
    27 Publications Verification

    13-Methylpalmatine nitrate

    		 Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy Infection Cancer
    Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) is an alkaloid. Dehydrocorydaline regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP . Dehydrocorydaline nitrate elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. . Dehydrocorydaline nitrate shows strong anti-malarial effects (IC50 =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .
    Dehydrocorydaline nitrate
  • HY-135858
    SARS-CoV-IN-3
    1 Publications Verification

    		 SARS-CoV Parasite HIV Infection
    SARS-CoV-IN-3 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-3 shows anti-Coronavirus activity with an EC50 of 3.6 μM in Vero cells. SARS-CoV-IN-3 inhibits the 3D7 and W2 strains of P. falciparum with IC50s of 11.7 and 20.4 nM; and IC90s of 29.19 and 56 nM; respectively. SARS-CoV-IN-3 reduces HIV-1-induced cytopathic effect with an EC50 of 10 μM in MT-4 cells .
    SARS-CoV-IN-3
  • HY-135856
    SARS-CoV-IN-2
    1 Publications Verification

    		 SARS-CoV Parasite HIV Infection
    SARS-CoV-IN-2 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-2 shows anti-Coronavirus activity with an EC50 of 1.9 μM in Vero cells. SARS-CoV-IN-2 inhibits the 3D7 and W2 strains of P. falciparum with IC50s of 21.5 and 30 nM; and IC90s of 51.0 and 99.9 nM; respectively. SARS-CoV-IN-2 reduces HIV-1-induced cytopathic effect with an EC50 of 2.9 μM in MT-4 cells. Antimalarial and Antiviral Activities .
    SARS-CoV-IN-2
  • HY-N2795
    9-Hydroxycalabaxanthone

    Xanthone I

    		 Parasite Bacterial Infection
    9-Hydroxycalabaxanthone (Xanthone I) is a known xanthone isolated from Garcinia mangostana Linn. 9-Hydroxycalabaxanthone has quorum-sensing inhibitory, anti-microbial, and anti-malarial activities (IC50=1.2-1.5 μM) .
    9-Hydroxycalabaxanthone
  • HY-100184
    DSM265
    1 Publications Verification

    		 Dihydroorotate Dehydrogenase Parasite Infection
    DSM265 is a long-duration inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 of 8.9 nM. DSM265 can also inhibit the growth of Pf3D7 parasites with an EC50 of 4.3 nM .
    DSM265
  • HY-162905
    Antimalarial agent 43

    		Parasite Infection
    Antimalarial agent 43 (compound 16c) is an antimalarial compound, with an IC50 value of 0.0151 μM against 3D7 strain .
    Antimalarial agent 43
  • HY-153547
    HSP90-IN-21

    		Parasite Infection Inflammation/Immunology
    HSP90-IN-21 (5e) is an antiplasmodial agent, with IC50 values of 0.04, 0.17 and 2.91 μM against erythrocytic stage of P. falciparum (Pf3D7 and PfDd2 strains), cytotoxicity of human liver hepatocellular carcinoma cell line (HepG2), respectively .
    HSP90-IN-21

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