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Results for "

5-HT1A Agonist

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (167) Adenylate Cyclase (1) Adrenergic Receptor (22) Apoptosis (1) Biochemical Assay Reagents (1) Cannabinoid Receptor (1) Dopamine Receptor (56) GABA Receptor (1) Isotope-Labeled Compounds (12) Parasite (1) Potassium Channel (2) Reactive Oxygen Species (5) Serotonin Transporter (12) Sigma Receptor (3)
By Research Areas:	Cancer (13) Cardiovascular Disease (3) Endocrinology (16) Infection (3) Inflammation/Immunology (8) Neurological Disease (157)

176

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12959A

Repinotan hydrochloride BAY x 3702	5-HT Receptor	Neurological Disease
Repinotan hydrochloride (BAY x 3702) is a potent, selective, brain-penetrant and orally active 5-HT1A receptor agonist, with K_i values of 0.19 nM (calf hippocampus), 0.25 nM (rat and human cortex), and 0.59 nM (rat hippocampus Repinotan hydrochloride has a weak affinity for other related receptors. Repinotan hydrochloride has pronounced neuroprotective effects .

HY-100166

AP521	5-HT Receptor	Neurological Disease
AP521 is an agonist of human 5-HT_1A receptor with an IC₅₀ of 94 nM.

HY-14785

Befiradol NLX-112; F13640	5-HT Receptor	Neurological Disease
Befiradol (NLX-112) is a selective *5-HT1A* receptor agonist.

HY-14785A

Befiradol hydrochloride NLX-112 hydrochloride; F 13640 hydrochloride	5-HT Receptor	Neurological Disease
Befiradol hydrochloride (NLX-112 hydrochloride) is a selective *5-HT_1A* receptor agonist.

HY-B0716

Urapidil	5-HT Receptor Adrenergic Receptor	Neurological Disease Endocrinology
Urapidil is an α1 adrenoreceptor antagonist and a 5-HT_1A receptor agonist.

HY-161105

FPIP	5-HT Receptor	Others
FPIP is a selectivity agonist of *5-HT1A* with a functional potency (pEC₅₀=8.92) .

HY-120498

RS-64459-193	5-HT Receptor	Neurological Disease
RS-64459-193 is a 5-HT1A receptor partial agonist with a K_i of 24.9 nM. RS-64459-193 also shows high affinity for 5-HT2C, 5-HT2A and 5-HT7 with pK_i values of 6.87, 7.02, and 7.18, respectively. RS-64459-193 is almost devoid of activity at the m 5-HT3 receptor .

HY-119775

U92016A	Others	Others
U92016A is a potent and selective agonist of the 5-HT1A receptor, with activities such as high affinity binding to the 5-HT1A receptor in vitro, causing a decrease in body temperature in vivo, and high potency and high intrinsic activity as an agonist in single-cell firing studies.

HY-N3398

Lauroscholtzine N-Methyllaurotetanine	5-HT Receptor	Neurological Disease
Lauroscholtzine (N-Methyllaurotetanine), a natural alkaloid, is a 5-HT1A receptor agonist .

HY-100426

Osemozotan MKC242 free base	Others	Others
Osemozotan (MKC242 free base) acts as an agonist for the 5-HT(1A) receptor.

HY-101609

Lesopitron dihydrochloride E4424	5-HT Receptor	Neurological Disease
Lesopitron dihydrochloride is a full and selective *5-HT_1A* receptor agonist with IC₅₀ of 125 nM in rat hippocampal membranes.

HY-14261

Vilazodone Hydrochloride 4 Publications Verification EMD 68843 Hydrochloride; SB659746A Hydrochloride	5-HT Receptor Serotonin Transporter	Neurological Disease
Vilazodone Hydrochloride (EMD 68843 Hydrochloride) is a serotonin transporter (SER) inhibitor and *5-HT_1A* receptor partial agonist.

HY-B0716S2

Urapidil-d4	Isotope-Labeled Compounds Adrenergic Receptor 5-HT Receptor	Endocrinology
Urapidil-d₄ is the deuterium labeled Urapidil[1]. Urapidil is an α1 adrenoreceptor antagonist and a 5-HT1A receptor agonist[2].

HY-B1115

Buspirone hydrochloride 1 Publications Verification	5-HT Receptor Reactive Oxygen Species	Neurological Disease Cancer
Buspirone hydrochloride is a 5-HT1A receptor agonist. Buspirone hydrochloride can be used for anxiety and depression research .

HY-106430

Piclozotan SUN N4057	5-HT Receptor	Neurological Disease
Piclozotan (SUN N4057) is a 5HT1A receptor agonist. Piclozotan improves motor complications in Parkinson's disease model .

HY-116076

S-15535	5-HT Receptor	Neurological Disease
S-15535 is a highly selective *5-HT_1A* receptor ligand. S-15535 is an antagonist of postsynaptic *5-HT_1A* receptors and an agonist of presynaptic *5-HT_1A* receptors. S-15535 can be used in research on psychiatric disorders, such as anti-anxiety .

HY-19863

F-15599 2 Publications Verification NLX-101	5-HT Receptor	Neurological Disease
F-15599 is a highly selective G-protein biased 5-HT1A receptor agonist, with K_i of 3.4 nM.

HY-19946

Eptapirone F 11440	5-HT Receptor	Neurological Disease
Eptapirone (F11440) is a potent and selective 5-HT_1A receptor agonist with marked anxiolytic and antidepressant potential .

HY-19134

EMD 56551	5-HT Receptor	Neurological Disease
EMD 56551 is a potent and selective 5-HT1A receptor agonist. EMD 56551 exerts anxiolytic activity .

HY-19863A

F-15599 tosylate NLX-101 tosylate	5-HT Receptor	Neurological Disease
F-15599 tosylate is a highly selective G-protein biased 5-HT1A receptor agonist, with K_i of 3.4 nM.

HY-19946A

Eptapirone fumarate F 11440 fumarate	5-HT Receptor	Neurological Disease
Eptapirone (F11440) fumarate is a potent and selective 5-HT_1A receptor agonist with marked anxiolytic and antidepressant potential .

HY-122422

Gepirone	5-HT Receptor	Others
Gepirone is a selective and affinitive *5-HT_1A* agonist. Gepirone binds selectively to 5-HT_1A receptor binding site. Gepirone acts as an antidepressant agent can be used for anxiety and major depressive disorder research .

HY-14546S

Aripiprazole-d8 OPC-14597-d₈	5-HT Receptor	Neurological Disease
Aripiprazole-d₈ is the deuterium labeled Aripiprazole, which is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM.

HY-W362839

Binospirone	5-HT Receptor	Neurological Disease
Binospirone is a 5-HT1A Receptor agonist. Binospirone has anxiolytic activity. Binospirone can be used in the study of movement disorders .

HY-14547

Bifeprunox	Dopamine Receptor 5-HT Receptor	Neurological Disease
Bifeprunox is a potent dopamine D2-like and 5-HT1A receptor partial agonist with pK_is of 7.19 and 8.83 for cortex 5-HT1A and striatum D2, and a pEC₅₀ of 6.37 for hippocampus 5-HT1A, respectively. Bifeprunox is an antipsychotic for the research of schizophrenia .

HY-14547A

Bifeprunox mesylate	Dopamine Receptor 5-HT Receptor	Neurological Disease
Bifeprunox mesylate is a potent dopamine D2-like and 5-HT1A receptor partial agonist with pK_is of 7.19 and 8.83 for cortex 5-HT1A and striatum D2, and a pEC₅₀ of 6.37 for hippocampus 5-HT1A, respectively. Bifeprunox mesylate is an antipsychotic for the research of schizophrenia .

HY-B0716S1

Urapidil-d3	5-HT Receptor Adrenergic Receptor	Neurological Disease Endocrinology
Urapidil-d₃ is the deuterium labeled Urapidil. Urapidil is an α1 adrenoreceptor antagonist and a 5-HT1A receptor agonist.

HY-19682

Enciprazine	5-HT Receptor	Neurological Disease
Enciprazine is a potent agonist *5-HT_1A* receptor. Enciprazine shows anxiolytic activity, and can be used in the research of anxiety disorders, and depression .

HY-169140

Zalospirone WY-47846	5-HT Receptor	Neurological Disease
Zalospirone (WY-47846) is a novel cyclic imide with *5-HT1A* partial agonist activity. Zalospirone shows antidepressant efficacy .

HY-118775

LEK 8804	Others	Others
LEK 8804 is a compound with 5-HT1A receptor agonist and 5-HT2 receptor antagonist properties, and has the activity of modulating related receptor-mediated behavioral responses. LEK 8804 can induce spontaneous tail-flick response in rats in a dose-dependent manner, showing complete 5-HT1A agonist activity, and can inhibit 5-HTP-induced head twitch response in mice, probably through antagonism of 5-HT2 receptors rather than agonism of 5-HT1A receptors.

HY-14958

Pardoprunox SLV-308; DU-126891	5-HT Receptor Adrenergic Receptor Dopamine Receptor	Neurological Disease Endocrinology
Pardoprunox (SLV-308) is a partial dopamine D2 and D3 receptor partial agonist and a *serotonin 5-HT1A* receptor** agonist, with pEC₅₀s of 8, 9.2, and 6.3, respectively .

HY-14958A

Pardoprunox hydrochloride SLV-308 hydrochloride; DU-126891 hydrochloride	5-HT Receptor Adrenergic Receptor Dopamine Receptor	Neurological Disease Endocrinology
Pardoprunox (SLV-308) hydrochloride is a partial dopamine D2 and D3 receptor partial agonist and a *serotonin 5-HT1A* receptor** agonist, with pEC₅₀s of 8, 9.2, and 6.3, respectively .

HY-146232

F 13714 F 14679	5-HT Receptor	Others
F 13714 (F 14679) is a prototypical *5-HT_1A* agonist with a pK_i of 10.23. F 13714 induces large Ca ²⁺ responses .

HY-167648

PD 158771	Dopamine Receptor 5-HT Receptor	Neurological Disease
PD 158771 is an antipsychotic agent that functions as a partial agonist for D₂ /D₃ receptors (K_i = 42.0/13.7 nM) and as an agonist for *5-HT_1A* receptors (K_i = 2.6 nM). PD 158771 can be utilized in antipsychotic research .

HY-14261S

Vilazodone-d8	5-HT Receptor Serotonin Transporter	Neurological Disease
Vilazodone-d₈ is the a deuterium labeled vilazodone, which is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist.

HY-106100A

Roxindole hydrochloride EMD 38362	Dopamine Receptor Serotonin Transporter	Neurological Disease
Roxindole hydrochloride (EMD 38362), an indot-alkyl-pipenidine, is a potent agonist at dopamine autoreceptors, with an affinity for the D2-like subtype in the low nanomolar range. Roxindole can be used for the research of positive and negative schizophrenic symptoms. Roxindole is a *5-HT_1A* agonist and 5-HT uptake inhibitor with high affinity for 5-HT_1A (IC₅₀=0.9 nM). Antipsychotic and antidepressant activities .

HY-111985

Revospirone BAY Vq 7813	5-HT Receptor Adenylate Cyclase	Others
Revospirone (BAY Vq 7813) is a partial agonist of the *5-HT_1A* receptor with a K_i of 2 nmol/L. Revospirone inhibits adenylate cyclase activity with an IC₅₀ of 124 nmol/L .

HY-B0716R

Urapidil (Standard)	5-HT Receptor Adrenergic Receptor	Neurological Disease Endocrinology
Urapidil (Standard) is the analytical standard of Urapidil. This product is intended for research and analytical applications. Urapidil is an α1 adrenoreceptor antagonist and a 5-HT_1A receptor agonist.

HY-117507

U92016A hydrochloride	5-HT Receptor	Neurological Disease
U92016A hydrochloride is a potent, metabolically stable, orally acitive *5-HT1A* receptor agonist with an exceptionally high degree of intrinsic activity . U92016A hydrochloride binds with high affinity to human 5-HT1A receptors expressed in Chinese hamster ovary cells (K_i=0.2 nM) .

HY-122422R

Gepirone (Standard)	5-HT Receptor	Others
Gepirone (Standard) is the analytical standard of Gepirone. This product is intended for research and analytical applications. Gepirone is a selective and affinitive *5-HT_1A* agonist. Gepirone binds selectively to 5-HT_1A receptor binding site. Gepirone acts as an antidepressant agent can be used for anxiety and major depressive disorder research .

HY-100820

Sarizotan 1 Publications Verification EMD 128130	5-HT Receptor Dopamine Receptor	Neurological Disease
Sarizotan (EMD 128130) is an orally active serotonin 5-HT_1A receptor and dopamine receptor agonist. Sarizotan (EMD 128130) exhibits IC₅₀ values of 6.5 nM (rat 5-HT_1A), 0.1 nM (human 5-HT_1A), 15.1 nM (rat D₂), 17 nM (human D₂), 6.8 nM (human D₃) and 2.4 nM (human D_4.2), respectively .

HY-100820B

Sarizotan dihydrochloride EMD 128130 dihydrochloride	5-HT Receptor Dopamine Receptor	Neurological Disease
Sarizotan dihydrochloride (EMD 128130) is an orally active serotonin 5-HT_1A receptor and dopamine receptor agonist. Sarizotan (EMD 128130) exhibits IC₅₀ values of 6.5 nM (rat 5-HT_1A), 0.1 nM (human 5-HT_1A), 15.1 nM (rat D₂), 17 nM (human D₂), 6.8 nM (human D₃) and 2.4 nM (human D_4.2), respectively .

HY-100820A

Sarizotan hydrochloride EMD 128130 hydrochloride	5-HT Receptor Dopamine Receptor	Neurological Disease
Sarizotan hydrochloride is an orally active serotonin 5-HT_1A receptor and dopamine receptor agonist. Sarizotan hydrochloride (EMD 128130) exhibits IC₅₀ values of 6.5 nM (rat 5-HT_1A), 0.1 nM (human 5-HT_1A), 15.1 nM (rat D₂), 17 nM (human D₂), 6.8 nM (human D₃) and 2.4 nM (human D_4.2), respectively .

HY-128901

F 13714 fumarate F 14679 fumarate	5-HT Receptor	Neurological Disease
F13714 fumarate, a selective 5-HT1A receptor biased agonist, shows antidepressant-like properties after a single administration in the mouse model of chronic mild stress .

HY-B1115A

Buspirone 1 Publications Verification	5-HT Receptor Dopamine Receptor Reactive Oxygen Species	Neurological Disease Cancer
Buspirone is an orally active 5-HT1A receptor agonist, and a dopamine D2 autoreceptorsant antagonist. Buspirone is an anxiolytic agent, and can be used for the generalized anxiety disorder research .

HY-117646

FG-5893	5-HT Receptor	Neurological Disease
FG-5893 is a 5-HT1A receptor agonist and a 5-HT2 receptor antagonist. FG-5893 has anxiolytic effect .

HY-14261R

Vilazodone Hydrochloride (Standard)	5-HT Receptor Serotonin Transporter	Neurological Disease
Vilazodone (Hydrochloride) (Standard) is the analytical standard of Vilazodone (Hydrochloride). This product is intended for research and analytical applications. Vilazodone Hydrochloride (EMD 68843 Hydrochloride) is a serotonin transporter (SER) inhibitor and *5-HT_1A* receptor partial agonist.

HY-106964A

(Rac)-S 16924	5-HT Receptor	Neurological Disease
(Rac)-S 16924 is a partial agonist of the *5-HT1A* receptor. (Rac)-S 16924 regulates signaling through its interaction with the *5-HT1A* receptor, and (Rac)-S 16924 can stabilize the receptor in its G-protein-coupled conformation without fully activating it, which may affect intracellular signaling pathways associated with this receptor. (Rac)-S 16924 can be used to study the *5-HT1A* receptor in mental disorders, especially schizophrenia .

HY-B1115R

Buspirone hydrochloride (Standard)	5-HT Receptor Reactive Oxygen Species	Neurological Disease Cancer
Buspirone (hydrochloride) (Standard) is the analytical standard of Buspirone (hydrochloride). This product is intended for research and analytical applications. Buspirone hydrochloride is a 5-HT1A receptor agonist. Buspirone hydrochloride can be used for anxiety and depression research .

HY-B1115S1

Buspirone-d8 (di(hydrochloride))	Isotope-Labeled Compounds 5-HT Receptor Reactive Oxygen Species	Neurological Disease Cancer
Buspirone-d8 dihydrochloride is the deuterium labeled Buspirone hydrochloride (HY-B1115). Buspirone hydrochloride is a 5-HT1A receptor agonist. Buspirone hydrochloride can be used for anxiety and depression research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2411

Geissoschizine methyl ether	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Structural Classification Source classification Rubiaceae Plants Indole Alkaloids	5-HT Receptor
Geissoschizine methyl ether, a major indole alkaloid found in Uncaria hook, is a major active component of Yokukansan with psychotropic effects. Geissoschizine methyl ether is potent 5-HT_1A receptor agonist .

HY-N0049

Nuciferine 4 Publications Verification	Structural Classification Alkaloids Aporphine Alkaloids other families Source classification Plants Isoquinoline Alkaloids	Parasite 5-HT Receptor Dopamine Receptor
Nuciferine is an antagonist at 5-HT_2A (IC₅₀=478 nM), 5-HT_2C (IC₅₀=131 nM), and 5-HT_2B (IC₅₀=1 μM), an inverse agonist at 5-HT₇ (IC₅₀=150 nM), a partial agonist at D₂ (EC₅₀=64 nM), D₅ (EC₅₀=2.6 μM) and 5-HT₆ (EC₅₀=700 nM), an agonist at *5-HT_1A* (EC₅₀=3.2 μM) and D₄ (EC₅₀=2 μM) receptor.

HY-N3398

Lauroscholtzine N-Methyllaurotetanine	Structural Classification Alkaloids Thalictrum revolutum DC. Source classification Ranunculaceae Plants Isoquinoline Alkaloids	5-HT Receptor
Lauroscholtzine (N-Methyllaurotetanine), a natural alkaloid, is a 5-HT1A receptor agonist .

HY-N0049R

Nuciferine (Standard)	Structural Classification Alkaloids other families Source classification Plants	5-HT Receptor Dopamine Receptor
Nuciferine (Standard) is the analytical standard of Nuciferine. This product is intended for research and analytical applications. Nuciferine is an antagonist at 5-HT_2A (IC₅₀=478 nM), 5-HT_2C (IC₅₀=131 nM), and 5-HT_2B (IC₅₀=1 μM), an inverse agonist at 5-HT₇ (IC₅₀=150 nM), a partial agonist at D₂ (EC₅₀=64 nM), D₅ (EC₅₀=2.6 μM) and 5-HT₆ (EC₅₀=700 nM), an agonist at *5-HT_1A* (EC₅₀=3.2 μM) and D₄ (EC₅₀=2 μM) receptor.

Cat. No.	Product Name	Chemical Structure

HY-14546S

Aripiprazole-d8
Aripiprazole-d₈ is the deuterium labeled Aripiprazole, which is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM.

HY-B0716S1

Urapidil-d3
Urapidil-d₃ is the deuterium labeled Urapidil. Urapidil is an α1 adrenoreceptor antagonist and a 5-HT1A receptor agonist.

HY-14261S

Vilazodone-d8
Vilazodone-d₈ is the a deuterium labeled vilazodone, which is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist.

HY-14546S1

Aripiprazole (1,1,2,2,3,3,4,4-d8) 5+ Cited Publications
Aripiprazole (1,1,2,2,3,3,4,4-d₈) is the deuterium labeled Aripiprazole. Aripiprazole (OPC-14597) is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM[1][2].

HY-B0716S2

Urapidil-d4
Urapidil-d₄ is the deuterium labeled Urapidil[1]. Urapidil is an α1 adrenoreceptor antagonist and a 5-HT1A receptor agonist[2].

HY-B1115S1

Buspirone-d8 (di(hydrochloride))
Buspirone-d8 dihydrochloride is the deuterium labeled Buspirone hydrochloride (HY-B1115). Buspirone hydrochloride is a 5-HT1A receptor agonist. Buspirone hydrochloride can be used for anxiety and depression research .

HY-A0095S

Flibanserin-d4
Flibanserin-d₄ is a deuterium labeled Flibanserin (BIMT-17). Flibanserin is a full agonist of the serotonin 5-HT1A receptor (Ki=1 nM) and an antagonist of 5-HT2A (49 nM)[1].

HY-15414AS

Vortioxetine-d8 hydrobromide
Vortioxetine-d₈ (Lu AA 21004-d₈) hydrobromide is the deuterated form of Vortioxetine. Vortioxetine (Lu AA 21004) is an antagonist of 5-HT_3A and 5-HT₇ receptors (K_i: 3.7 nM, 19 nM) and an inhibitor of 5-hydroxytryptamine transporter (SERT) (K_i: 1.6 nM), as well as a 5-HT_1A agonist and a partial 5-HT_1B agonist (K_i: 15 nM, 33 nM) .

HY-15414S

Vortioxetine-d8
Vortioxetine-d₈ (Lu AA 21004-d₈) is a deuterated version of Vortioxetine. Vortioxetine (Lu AA 21004) is an antagonist of 5-HT_3A and 5-HT₇ receptors (K_i: 3.7 nM, 19 nM) and an inhibitor of 5-hydroxytryptamine transporter (SERT) (K_i: 1.6 nM), as well as a 5-HT_1A agonist and a partial 5-HT_1B agonist (K_i: 15 nM, 33 nM) .

HY-B0032AS

Lurasidone-d8
Lurasidone-d₈ is deuterium labeled Lurasidone. Lurasidone (SM-13496) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (SM-13496) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM.

HY-15414S1

Vortioxetine-d6
Vortioxetine-d6 (Lu AA 21004-d6) is the deuterium labeled Vortioxetine (HY-B1490A). Vortioxetine (Lu AA 21004) is an antagonist of 5-HT_3A and 5-HT₇ receptors (K_i: 3.7 nM, 19 nM) and an inhibitor of serotonin transporter (SERT) (K_i: 1.6 nM), as well as a **5-HT_1A agonist and a partial agonist of 5-HT_1B (K_i: 15 nM, 33 nM) .**

HY-B0982S

Pindolol-d7
Pindolol-d₇ (LB-46-d7) is the deuterium labeled Pindolol. Pindolol (LB-46) is a nonselective β-blocker with partial beta-adrenergic receptor agonist activity, also functions as a 5-HT1A receptor weak partial antagonist (Ki=33 nM)[1][2].

HY-14262S1

Vilazodone-d8 hydrochloride
Vilazodone-d₈ hydrochloride is deuterated labeled Vilazodone (HY-14262). Vilazodone (EMD 68843; SB 659746A) is a potent, selective and orally active serotonin reuptake inhibitor (SSRI) and partial 5-HT₁A receptor agonist. Vilazodone exhibits antidepressant efficacy in vivo can be used for the research of major depressive disorder (MDD) and affective disorders .

HY-15780S

Brexpiprazole-d8
Brexpiprazole-d₈ is a deuterium labeled Brexpiprazole (OPC-34712). Brexpiprazole, an atypical antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine receptor (Ki=0.12 nM and 0.3 nM, respectively). Brexpiprazole is also a 5-HT2A receptor antagonist (Ki=0.47 nM)[1][2].

HY-B0121BS

Sumatriptan-d6 succinate
Sumatriptan-d6 succinate is the deuterium labeled Sumatriptan succinate. Sumatriptan succinate is an orally active 5-HT1 receptor agonist with K_is of 17 nM, 27 nM and 100 nM for 5-HT1D, 5-HT1B and 5-HT1A receptors, respectively. Sumatriptan succinate can be used for migraine headache research .

HY-A0095S1

Flibanserin-d4-1

Flibanserin-d₄-1 is deuterium labeled Flibanserin. Flibanserin (BIMT-17) is a full agonist of the serotonin 5-HT1A receptor (Ki=1 nM) and an antagonist of 5-HT2A (49 nM). Flibanserin binds to dopamine D4 receptors (4-24 nM), and has negligible affinity for a variety of other neurotransmitter receptors and ion channels. Flibanserin is efficacious in treating hypoactive sexual desire disorder (HSDD)[1][2].

HY-133152S

Brexpiprazole S-oxide-d8

Brexpiprazole S-oxide-d₈ is a deuterium labeled Brexpiprazole S-oxide. Brexpiprazole S-oxide is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM[1][2][3].

HY-B0031S2

Quetiapine-d8 fumarate

Quetiapine-d₈ (fumarate) is the deuterium labeled Quetiapine. Quetiapine is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects[1][2].

HY-15780S1

Brexpiprazole-d8-1

Brexpiprazole-d₈-1 is the deuterium labeled Brexpiprazole[1]. Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM)[2][3].

HY-B0031S3

Quetiapine-d8 hemifumarate

Quetiapine-d₈ (hemifumarate) is the deuterium labeled Quetiapine hemifumarate. Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects[1].

HY-B0031S4

Quetiapine hemifumarate-d8

Quetiapine (hemifumarate)-d₈ is the deuterium labeled Quetiapine hemifumarate[1]. Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects[2].

HY-B0031S5

Quetiapine-d4-1 fumarate

Quetiapine-d₄-1 fumarate is deuterated labeled Quetiapine (hemifumarate) (HY-B0031). Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC₅₀ of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC₅₀ of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pK_is of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects .

HY-B1658BS

Frovatriptan-d3 succinate

Frovatriptan-d₃ (succinate) is deuterium labeled Frovatriptan (succinate). Frovatriptan succinate ((R)-Frovatriptan succinate) is a potent, high affinity, selective and orally active 5-HT1B (pK50 of 8.2) and 5-HT1D receptor agonist. Frovatriptan succinate exhibits >10-fold selectivity for 5-HT1B and 5-HT1D over 5-HT1A, 5-HT1F, and 5-HT7 and >1000-fold selectivity over other 5-HT, dopamine, histamine H1, and α1-adrenoceptor. Frovatriptan succinate has the potential for migraine research[1][2].

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