2. GPCR/G Protein Neuronal Signaling Apoptosis
  3. 5-HT Receptor Apoptosis
  4. 1-(1-Naphthyl)piperazine hydrochloride

1-(1-Naphthyl)piperazine hydrochloride  (Synonyms: 1-NP hydrochloride; 1-Naphthylpiperazine hydrochloride)

Cat. No.: HY-112538
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1-1-Naphthylpiperazine hydrochloride (1-NP hydrochloride; 1-Naphthylpiperazine hydrochloride) is a serotonergic derivative of quipazine, which is both an agonist for 5-HT1A receptor and an antagonist for 5-HT2A receptor. 1-1-Naphthylpiperazine hydrochloride induces cell apoptosis. 1-1-Naphthylpiperazine hydrochloride prevents the immunosuppression and photocarcinogenesis.

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1-(1-Naphthyl)piperazine hydrochloride Chemical Structure

1-(1-Naphthyl)piperazine hydrochloride Chemical Structure

CAS No. : 104113-71-5

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1-(1-Naphthyl)piperazine hydrochloride Related Antibodies

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Description

1-1-Naphthylpiperazine hydrochloride (1-NP hydrochloride; 1-Naphthylpiperazine hydrochloride) is a serotonergic derivative of quipazine, which is both an agonist for 5-HT1A receptor and an antagonist for 5-HT2A receptor. 1-1-Naphthylpiperazine hydrochloride induces cell apoptosis. 1-1-Naphthylpiperazine hydrochloride prevents the immunosuppression and photocarcinogenesis[1].

IC50 & Target

5-HT1A Receptor

 

5-HT2A Receptor

 

In Vitro

1-1-Naphthylpiperazine hydrochloride (50-300 μM) suppresses the melanoma cells MNT-1 with an IC50 is 163.6 μM, by inducing the cell cycle arrest at S-phase, cell apoptosis and ROS generation[1].
1-1-Naphthylpiperazine hydrochloride (0-200 μM) regulates the expressions of related genes, which are associated with the UV-induced immunosuppression[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1-(1-Naphthyl)piperazine hydrochloride Related Antibodies

Cell Viability Assay[1]

Cell Line: MNT-1
Concentration: 50-300 μM
Incubation Time: 3-24 h
Result: Inhibited cell viability

RT-PCR[1]

Cell Line: MNT-1
Concentration: 0-150 μM
Incubation Time: 24 h
Result: Downregulated levels of PAK1, upregulated levels of PTGS2 and IL12A.
In Vivo

1-1-Naphthylpiperazine hydrochloride (1 μM, i.p., single dose) promotes the DNA repair induced by UV radiation through the mechanism involving nucleotid excision repair(NER), which prevents the immune suppression and interferes the photocarcinogenesis in UVB exposed C57BL/6 mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: UVB-radiation exposed C57BL/6 mice and XPA-/- mice[2]
Dosage: 1 μM
Administration: i.p., single dose
Result: Accelerated the repair of UV-induced photoproducts with presence of NER.
Molecular Weight

248.75

Formula

C14H17ClN2
CAS No.
SMILES

C12=C(C=CC=C2N3CCNCC3)C=CC=C1.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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1-(1-Naphthyl)piperazine hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-(1-Naphthyl)piperazine104113-71-51-NP1-Naphthylpiperazine5-HT ReceptorApoptosisSerotonin Receptor5-hydroxytryptamine ReceptorSK-MEL-28MNT-1C57BL/6 mouseXPA-/- mouseInhibitorinhibitorinhibit

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