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Results for "

543

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (4) Autophagy (3) Bacterial (1) Cannabinoid Receptor (1) COX (1) Epigenetic Reader Domain (1) Fluorescent Dye (7) GABA Receptor (1) GPR55 (1) HSP (1) JAK (1) LPL Receptor (3) MicroRNA (12) NO Synthase (1) Parasite (1) Potassium Channel (1) Prolyl Endopeptidase (PREP) (1) Reactive Oxygen Species (1) RET (1) SGLT (1) SphK (3) Tyrosinase (1)
By Research Areas:	Cancer (20) Cardiovascular Disease (5) Infection (3) Inflammation/Immunology (5) Metabolic Disease (2) Neurological Disease (4)
Click Chemistry:	Azide (1)
Oligonucleotides:	miRNA mimics (3) miRNA agomirs (3) miRNA antagomirs (3) MicroRNAs (12) miRNA inhibitors (3)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108590

DMP-543 XR-543	Potassium Channel	Neurological Disease
DMP-543 (XR-543) is a K_V7 channel blocker, also acts as a potent neurotransmitter release enhancer .

HY-15425

PF-543 5+ Cited Publications Sphingosine Kinase 1 Inhibitor II	SphK LPL Receptor Apoptosis Autophagy	Cardiovascular Disease Inflammation/Immunology Cancer
PF-543 (Sphingosine Kinase 1 Inhibitor II) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC₅₀ of 2 nM and a K_i of 3.6 nM. PF-543 is >100-fold selectivity for SPHK1 over SPHK2. PF-543 is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC₅₀ of 26.7 nM. PF-543 induces apoptosis, necrosis, and autophagy .

HY-15425A

*PF-543* Citrate** 5+ Cited Publications Sphingosine Kinase 1 Inhibitor II Citrate	SphK LPL Receptor Apoptosis Autophagy	Cardiovascular Disease Inflammation/Immunology Cancer
PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC₅₀ of 2 nM and a K_i of 3.6 nM. PF-543 Citrate is >100-fold selectivity for SPHK1 over SPHK2. PF-543 Citrate is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC₅₀ of 26.7 nM. PF-543 Citrate induces apoptosis, necrosis, and autophagy .

HY-14526

5-DACTHF 543U76; 5,11-Methenyltetrahydrohomofolate	Others	Cancer
5-DACTHF (543U76) is an inhibitor of purine de novo biosynthesis. 5-DACTHF is a GAR-TFase and AICAR-TFase inhibitor (IC₅₀: 3 and 94 μM). 5-DACTHF is a potent antitumor agent .

HY-125327

YM-543	Others	Metabolic Disease
YM-543 is a selective SGLT2 inhibitor that effectively reduces hyperglycemia in type 2 diabetic mice through increased urinary glucose excretion. YM-543 demonstrates potent inhibition of both mouse and human SGLT2 activities at nanomolar concentrations. YM-543, when administered orally, significantly improves glucose tolerance in diabetic models and sustains its effects for over 12 hours. YM-543, in combination with other antidiabetic agents like rosiglitazone or metformin, enhances the therapeutic effects on diabetic symptoms. YM-543 does not affect blood glucose levels in normal mice, indicating its specificity for diabetic conditions.

HY-122613

YM543 free base	SGLT	Metabolic Disease
YM543 free base is a potent and orally active sodium-glucose cotransporter (SGLT) 2 inhibitor. YM543 free base reduces blood glucose levels. YM543 free base can be used in research of diabetes .

HY-R01626

*hsa-miR-543* mimic**	MicroRNA	Cancer
hsa-miR-543 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-543 mimic hsa-miR-543 mimic

HY-15425B

*PF-543* hydrochloride** Sphingosine Kinase 1 Inhibitor II hydrochloride	SphK LPL Receptor Apoptosis Autophagy	Cardiovascular Disease Inflammation/Immunology Cancer
PF-543 hydrochloride (Sphingosine Kinase 1 Inhibitor II hydrochloride) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC₅₀ of 2 nM and a K_i of 3.6 nM. PF-543 hydrochloride is >100-fold selectivity for SPHK1 over SPHK2. PF-543 hydrochloride is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC₅₀ of 26.7 nM. PF-543 hydrochloride induces apoptosis, necrosis, and autophagy .

HY-RI01626

*hsa-miR-543* inhibitor**	MicroRNA	Cancer
hsa-miR-543 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-543 inhibitor hsa-miR-543 inhibitor

HY-R01626A

*hsa-miR-543* agomir**	MicroRNA	Cancer
hsa-miR-543 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-543 agomir hsa-miR-543 agomir

HY-RI01626A

*hsa-miR-543* antagomir**	MicroRNA	Cancer
hsa-miR-543 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-543 antagomir hsa-miR-543 antagomir

HY-R03291

*mmu-miR-543-5p mimic*	MicroRNA	Cancer
mmu-miR-543-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-miR-543-5p mimic mmu-miR-543-5p mimic

HY-R04514

*rno-miR-543-3p mimic*	MicroRNA	Cancer
rno-miR-543-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

rno-miR-543-3p mimic rno-miR-543-3p mimic

HY-RI03291

*mmu-miR-543-5p inhibitor*	MicroRNA	Cancer
mmu-miR-543-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-miR-543-5p inhibitor mmu-miR-543-5p inhibitor

HY-RI04514

*rno-miR-543-3p inhibitor*	MicroRNA	Cancer
rno-miR-543-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

rno-miR-543-3p inhibitor rno-miR-543-3p inhibitor

HY-R03291A

*mmu-miR-543-5p agomir*	MicroRNA	Cancer
mmu-miR-543-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-543-5p agomir mmu-miR-543-5p agomir

HY-R04514A

*rno-miR-543-3p agomir*	MicroRNA	Cancer
rno-miR-543-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

rno-miR-543-3p agomir rno-miR-543-3p agomir

HY-RI04514A

*rno-miR-543-3p antagomir*	MicroRNA	Cancer
rno-miR-543-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

rno-miR-543-3p antagomir rno-miR-543-3p antagomir

HY-RI03291A

*mmu-miR-543-5p antagomir*	MicroRNA	Cancer
mmu-miR-543-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-543-5p antagomir mmu-miR-543-5p antagomir

HY-125959

Ucf-101 1 Publications Verification	Apoptosis	Cardiovascular Disease Neurological Disease
Ucf-101 is a selective and competitive inhibitor of pro-apoptotic protease Omi/HtrA2, with an IC₅₀ of 9.5 μM for His-Omi. Ucf-101 exhibits very little activity against various other serine proteases (IC₅₀>200 μM). Ucf-101 has a natural red fluorescence at 543 nm that is used to monitor its ability to enter mammalian cells. Ucf-101 has a significant cardioprotective effect against MI/R injury and also has certain neuroprotective effect .

HY-D0304

Rhodamine B base Solvent red 49	Fluorescent Dye	Others
Rhodamine B base (Solvent red 49) is a fluorescent dye (Ex=543 nM; Em=565 nM) .

HY-D1704

Bodipy TMR-X muscimol	GABA Receptor	Neurological Disease
Bodipy TMR-X muscimol is a Bodipy labeled Muscimol (HY-N2313) (Ex=543 nm, Em=572 nm). Muscimol is a GABAA agonist. Bodipy TMR-X muscimol can be used for imaging the spread of reversible brain inactivations .

HY-112728

MMV024101	Parasite	Infection
MMV024101 shows potency against P. falciparum NF54 with an IC₅₀ value of 543 nM, which has antiplasmodial activity .

HY-158739

Rhodamine dithenoyl hydrazide	Fluorescent Dye	Cancer
Rhodamine dithenoyl hydrazide possesses excellent recognition and selectivity for Fe ³⁺ ion. Rhodamine dithenoyl hydrazide exhibits Excitation/Emission maxima of 543/550-700 nm, respectively .

HY-100696

PNZ5	Epigenetic Reader Domain	Cancer
PNZ5 is a potent and isoxazole-based pan-BET inhibitor with high selectivity and potency similar to the well-established (+)-JQ1, with a K_D of 5.43 nM for BRD4(1) .

HY-D1148

HKGreen-4I 1 Publications Verification	Fluorescent Dye	Others
HKGreen-4I is a highly sensitive green fluorescent probe for the specific detection of ONOO ^- in living cells with a maximum excitation wavelength and emission wavelength of 520 nm and 543 nm, respectively .

HY-130022

HKPerox-1 1 Publications Verification	Fluorescent Dye	Others
HKPerox-1 is a highly sensitive green fluorescent probe for the specific detection of H₂O₂ in living cells with a maximum excitation wavelength and emission wavelength of 520 nm and 543 nm, respectively .

HY-D1157

HKPerox-2 3 Publications Verification	Fluorescent Dye Reactive Oxygen Species	Others
HKPerox-2 is a highly sensitive green fluorescent probe for the specific detection of H₂O₂ in living cells with a maximum excitation wavelength and emission wavelength of 520 nm and 543 nm, respectively .

HY-50856S

Deuruxolitinib CTP-543; Ruxolitinib d₈; Deuterated Ruxolitinib	JAK	Inflammation/Immunology
Deuruxolitinib, a deuterated Ruxolitinib (HY-50856), is an orally active JAK1 and JAK2 inhibitor. Deuruxolitinib demonstrates significant hair regrowth effects. Deuruxolitinib can be used for the research of alopecia areata .

HY-N4005

Isoastilbin	Bacterial Tyrosinase	Infection Neurological Disease
Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC₅₀ value of 54.3 μg/mL, and also inhibits tyrosinase activity. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer’s disease research .

HY-103336

Tocrifluor 1117 T1117	GPR55 Cannabinoid Receptor	Cardiovascular Disease
Tocrifluor 1117 (T1117), a fluorescent form of the cannabinoid CB1 receptor antagonist AM251 (HY-15443), is a selective fluorescent GPR55 ligand. Tocrifluor 1117 is a potent tool for identifying the cellular location of cannabinoid receptors (including GPR55 in living tissues) (Ex/Em=543/590 nm) .

HY-15112

JTP-4819	Prolyl Endopeptidase (PREP)	Infection
JTP-4819 is a potent and specific inhibitor of prolyl endopeptidase (PREP) with IC₅₀s of 0.83 nM (in rat brain supernatant) and 5.43 nM (in Flavobacterium meningosepticum). JTP-4819 has blood-brain penetration, also improves the retention time of amnesia rats induced by Scopolamine (HY-N2096) .

HY-114289

6-HEX	Fluorescent Dye	Others
6-HEX is one kind of light base group, the wave length is 532 nm, the wave length is 556 nm. 6-HEX can be used to record nucleic acid sequences and design optical materials. 6-HEX can be used to record nucleic acids at 543 nm radiation, and at 550 nm and 650 nm radiation (5 nm radiation), it can be used to directly locate the base of the cell group .

HY-15096

MKT-077 Maximum Cited Publications 10 Publications Verification FJ-776	Fluorescent Dye HSP	Cancer
MKT-077 (FJ-776), a highly water-soluble mitochondrial dye, has significant antitumor activity . MKT-077 exhibits low cytotoxicity, and inhibits broad-spectrum human cancer cell lines (colon cancer, breast cancer, pancreatic cancer). MKT-077 inhibits the growth of tumor in nude mice enograft tumor model. Ex/Em=488/543 nm .

HY-146710

RET-IN-16	RET	Cancer
RET-IN-16 is a potent and selective RET inhibitor with IC₅₀s of 3.98 nM, 8.42 nM, 15.05 nM, 7.86 nM, 5.43 nM and 8.86 nM for RET(WT), RET(M918T), RET(V804L), RET(V804M), RET-CCDC6 and RET-KIF5B, respectively. RET-IN-16 has anticancer effects .

HY-159564

iNOS/COX-2-IN-3	COX NO Synthase	Inflammation/Immunology
iNOS/COX-2-IN-3 (compound 7d) is a dual inhibitor of iNOS and COX-2, with potential anti-inflammatory activity against LPS (HY-D1056)-induced RAW 264.7 cells (IC₅₀=3.48 μM). iNOS/COX-2-IN-3 has good plasma stability, oral activity and gastric safety, and its inhibitory activity on iNOS and COX-2 expression is 5.43-fold and 2.37-fold that of Indomethacin (HY-14397), respectively .

Cat. No.	Product Name	Type