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Results for "

A3AR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (32) Apoptosis (1) Fluorescent Dye (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (2) Inflammation/Immunology (19) Neurological Disease (8)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-158180

A3AR agonist 4	Adenosine Receptor	Inflammation/Immunology
A3AR agonist 4 is an A3 adenosine receptor (A3AR) agonist (K_i: 1.24 nM for hA3AR). A3AR agonist 4 inhibits cAMP production with an EC₅₀ of 0.17 nM. A3AR agonist 4 can be used for research of inflammation and pain .

HY-120652

A3AR antagonist 3	Adenosine Receptor	Inflammation/Immunology
A3AR antagonist 3 (compound 21) is a selective A3 adenosine receptor (A3AR) antagonist with a K_i of 37 nM. A3AR antagonist 3 shows >60-fold selectivity in comparison to A1 and A2A adenosine receptors .

HY-134555

A3AR antagonist 4	Adenosine Receptor	Neurological Disease
A3AR antagonist 4 (Compd 1) is an *A3AR* antagonist, with K_i values of 30.8 nM (hA₃) and 203 nM (hA₁), repectively. A3AR antagonist 4 (Compd 1) can be used for the study of cerebral ischemia .

HY-151899

A3AR modulator 1	Adenosine Receptor	Inflammation/Immunology
A3AR modulator 1 (MRS8054) is an orally active A3 adenosine receptor (A3AR) (Adenosine Receptor) positive allosteric modulator (PAM). A3AR modulator 1 greatly enhances Cl-IB-MECA-stimulated [ ³⁵S]GTPγS binding E_max .

HY-155183

A3AR agonist 1	Adenosine Receptor	Inflammation/Immunology Cancer
A3AR agonist 1 (Compound 12) is an *A3AR* agonist (K_i: 25.8 nM). A3AR agonist 1 stimulates β-arrestin2 recruitment, with an EC₅₀ value of 5.17 nM. A3AR agonist 1 can be used for research of inflammatory diseases, ischemia, cancer, neuropathic pain, liver diseases, etc .

HY-158179

A3AR agonist 3	Adenosine Receptor	Neurological Disease
A3AR agonist 3 (Compound 15A) is a A3 adenosine receptor (A3AR) agonist, with K_i and EC₅₀ values of 2.27 and 0.20 nM for hA3 and cAMP, respectivelly. A3AR agonist 3 can be used for the research of neuroinflammation .

HY-158181

A3AR agonist 5	Adenosine Receptor	Inflammation/Immunology
A3AR agonist 5 (Compound 6b) is a A3 adenosine receptor (A3AR) activator, with EC₅₀ and K_i values of 0.14 nM and 6.36 nM for cAMP and hA3, respectively. A3AR agonist 5 can be used in pain and inflammatory research .

HY-155184

A3AR agonist 2	Adenosine Receptor	Neurological Disease Inflammation/Immunology Cancer
A3AR agonist 2 (Compound 19) a selective *A3AR* agonist (K_i: 22.1 nM). A3AR agonist 2 stimulates β-arrestin2 recruitment, with EC₅₀ value of 4.36 nM. A3AR agonist 2 can be used for research of inflammatory diseases, ischemia, cancer, neuropathic pain, liver diseases, and other chronic conditions . A3AR agonist 2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-146457

A3AR antagonist 1	Adenosine Receptor	Inflammation/Immunology
A3AR antagonist 1 (compound 17) is a potent and selective human A₃ adenosine receptor (AR) antagonist, with an K_i of 4.63 nM. A3AR antagonist 1 shows no affinity for the rat A₃ AR even at high concentrations .

HY-12099

A3AR antagonist 2	Adenosine Receptor	Inflammation/Immunology
A3AR antagonist 2 (compound 18) is a potent Human A3 adenosine receptor antagonist with an K_i value of 4.54 nM .

HY-164621

A3AR antagonist 5	Adenosine Receptor	Others
A3AR antagonist 5 (Compound 16) is a selective antagonist for human adenosine A3 receptor with an affinity pC of 4.542 μM .

HY-156983

MRS 5980	Adenosine Receptor	Neurological Disease
MRS 5980 is an *A3AR* agonist with a K_i value of 0.7 nM. MRS 5980 has oral activity .

HY-159889

hA3AR agonist 2	Adenosine Receptor	Others
hA3AR agonist 2 (compound 1h) is an *A3AR* agonist, with a K_i of 3.5 nM.

HY-155772

LUF7690	Adenosine Receptor Fluorescent Dye	Inflammation/Immunology
LUF7690 (Compound 9) is a clickable and covalent affinity-based probe (AfBP) that targets the human A3AR (hA3AR). LUF7690 can be used in the detection and characterization of the hA3AR in different types of granulocytes, among other cell types .

HY-110202

MRS5698	Adenosine Receptor	Neurological Disease Inflammation/Immunology
MRS5698 is a selective G_i protein-coupled A₃ adenosine receptor (A₃AR) agonist, with K_is of approximately 3 nM for human and mouse A₃AR, respectively. MRS5698 can be used for the research of pain and psoriasis .

HY-124259

I-AB-MECA	Adenosine Receptor	Others
I-AB-MECA is an important radioligand for the study of A₃ adenosine receptors (A₃AR) .

HY-161810

MRS8247	Adenosine Receptor	Others
MRS8247 is a positive allosteric modulator (PAM) of the A3 adenosine receptor (A3AR) that can also slow the dissociation rate of agonists .

HY-122231

MRS3558	Adenosine Receptor	Neurological Disease
MRS3558 is a potent and selective *A3AR* agonist, with K_i values of 0.6 nM for humans and 0.9 nM for rats, making it suitable for research in the fields of neuropathic pain and anesthesia .

HY-161718

MRS8028	Adenosine Receptor	Inflammation/Immunology
MRS8028 is an agonist for A3 adenosine receptor (A3AR), which binds hA3AR with K_i of 2.44 nM. MRS8028 is potential for ameliorating ischemia and inflammatory diseases .

HY-161717

MRS5663	Adenosine Receptor	Cardiovascular Disease
MRS5663 (Compound 3a) is an *A3AR* agonist, with an EC₅₀ of 5.62 nM for β-arrestin2 recruitment assay. MRS5663 has a cytoprotective effect on skeletal muscle ischemia-reperfusion injury/claudication model .

HY-12365

Namodenoson 2 Publications Verification CF-102; 2-Cl-IB-MECA	Adenosine Receptor	Cancer
Namodenoson (CF-102) is a selective A3 adenosine receptor (A3AR) agonist (K_i=0.33 nM). Namodenoson displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively .

HY-12365R

Namodenoson (Standard)	Adenosine Receptor	Cancer
Namodenoson (Standard) is the analytical standard of Namodenoson. This product is intended for research and analytical applications. Namodenoson (CF-102) is a selective A3 adenosine receptor (A3AR) agonist (K_i=0.33 nM). Namodenoson displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively .

HY-13591

Piclidenoson 5+ Cited Publications IB-MECA; CF-101	Adenosine Receptor Apoptosis	Inflammation/Immunology Cancer
Piclidenoson (IB-MECA) is a first-in-class, orally active and selective A3 adenosine receptor (A3AR) agonist. Piclidenoson exhibits antiproliferative effect and induces apoptosis in different cancer cell types like melanoma, leukemia. Piclidenoson can be used for the research of autoimmune inflammatory diseases and COVID-19 ^[3] .

HY-147907

Adenosine receptor inhibitor 1	Adenosine Receptor	Neurological Disease Inflammation/Immunology Cancer
Adenosine receptor inhibitor 1 is a potent and selective adenosine receptor (AR) inhibitor with K_i values of >1000, 68.5, >1000, >1000 nM for A₁AR, A_2AAR, A_2BAR, A₃AR, respectively. Adenosine receptor inhibitor 1 shows antinociceptive activity, anti-inflammatory effect and peripheral analgesic effect. Adenosine receptor inhibitor 1 has the potential for the research of cancer or neurodegenerative diseases .

HY-103177

PSB-10 hydrochloride	Adenosine Receptor	Inflammation/Immunology
PSB-10 hydrochloride is a potent and selective antagonist of human adenosine A3 receptor (A₃AR), with a K_i of 0.44 nM. PSB-10 hydrochloride shows more than 800-fold selectivity for hA₃ over rA₁, rA_2A, hA₁, hA_2A and hA_2B receptors (K_i=805, 6040, 1700, 2700, 30000 nM, respectively). PSB-10 hydrochloride produces thermal hyperalgesia in mice .

HY-153152

DPTN dihydrochloride	Adenosine Receptor	Inflammation/Immunology
DPTN is a potent and selective human, mouse, and rat A ³AR antagonist with K_i values of 1.65, 9.61, and 8.53 nM, respectively .

HY-147541

A2A/A3 AR antagonist-1	Adenosine Receptor	Inflammation/Immunology
A2A/A3 AR antagonist-1 (compound 23) is a dual A_2A/A₃ adenosine receptor (AR) fluorescent ligand, with K_is of 90 nM and 31.8 nM for hA_2A AR and hA₃ AR, respectively .

HY-146479

A1/A3 AR antagonist 2	Adenosine Receptor	Inflammation/Immunology
The compound is an a1/a3 adenosine receptor antagonist, which helps to research (neurological) inflammatory diseases.

HY-153333

A1/A3 AR antagonist 3	Adenosine Receptor	Cardiovascular Disease
A1/A3 AR antagonist 3 is an *A₁R/A₃R* dual antagonist with high affinity at low-micromolar to low-nanomolar. A1/A3 AR antagonist 3 can be used for the research of chronic heart diseases .

HY-146478

A1/A3 AR antagonist 1	Adenosine Receptor	Neurological Disease Inflammation/Immunology
A1/A3 AR antagonist 1 (compound 10) is a potent adenosine 1 (A1) and adenosine 3 (A3) receptor dual antagonist with K_is of 36.7 nM, 25.4 nM and 1.47 nM for human A1, human A3 and rat A1, respectively. A1/A3 AR antagonist 1 can be used for researching kidney failure, inflammatory pulmonary diseases, and Alzheimer’s disease .

HY-162851

Adenosine receptor agonist 1	Adenosine Receptor	Others
Adenosine receptor agonist 1 (compound 6m) is an A3 adenosine receptor (AR) partial agonist with K_i value of 6.7 nM .

HY-101854

N6-(2-Phenylethyl)adenosine N6-Phenethyladenosine; N6-Phenylethyladenosine	Adenosine Receptor	Inflammation/Immunology Cancer
N6-(2-Phenylethyl)adenosine (N6-Phenethyladenosine), an adenosine derivative, is a potent adenosine receptors (AR) agonist with K_i values of 11.8 nM, 30.1 nM, 0.63 nM for rat A₁AR, human A₁AR and hA₃AR, respectively .

Cat. No.	Product Name		Classification

HY-155772

LUF7690		Alkynes
LUF7690 (Compound 9) is a clickable and covalent affinity-based probe (AfBP) that targets the human A3AR (hA3AR). LUF7690 can be used in the detection and characterization of the hA3AR in different types of granulocytes, among other cell types .

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