AC4

By Targets:	Apoptosis (1) Biochemical Assay Reagents (3) DNA/RNA Synthesis (1) Dopamine Transporter (1) Endogenous Metabolite (4) GnRH Receptor (1) PROTAC Linkers (3) STAT (1)
By Research Areas:	Cancer (4) Endocrinology (1) Metabolic Disease (2) Neurological Disease (1)
Click Chemistry:	Labeling and Fluorescence Imaging (1) PROTAC Synthesis (2) Azide (2) Alkynes (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-124500

AC-4-130 3 Publications Verification	STAT Apoptosis	Cancer
AC-4-130 is a potent STAT5 SH2 domain inhibitor. AC-4-130 directly binds to STAT5 and disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription. AC-4-130 induces cell cycle arrest and apoptosis in FLT3-ITD-driven leukemic cells. AC-4-130 has anti-cancer activity and can efficiently block pathological levels of STAT5 activity in acute myeloid leukemia (AML) .

HY-W728531

Ac4ManNAz 1 Publications Verification	Biochemical Assay Reagents	Others
Ac4ManNAz can be taken up by cells and is an azide-containing metabolic glycoprotein labeling reagent that selectively modifies proteins. Commonly used for cell labeling, tracking and proteomic analysis. Ac4ManNAz contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Ac4ManNAz can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-118297

Ac4ManNAz (80% α isomer) 2 Publications Verification	Biochemical Assay Reagents	Metabolic Disease
Ac4ManNAz is an azido-containing metabolic glycoprotein labeling reagent. Ac4ManNAz can be used to selectively modify proteins. Ac4ManNAz can be used in cell labeling, tracking and proteomic analysis . Ac4ManNAz is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-141128

Ac4GalNAz	PROTAC Linkers	Cancer
Ac4GalNAz is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . Ac4GalNAz is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-110209

*AC4*	Others	Others
AC4 is a trans antagonist upon voltageactivation of TRPV1 and as cis antagonist of TRPV1 currents upon stimulation with Capsaicin (CAP) (HY-10448). AC4 demonstrates that a photoswitchable antagonist and an agonist can be used in concert .

HY-161160

Ac4ManNDAz	Others	Others
Ac4ManNDAz is a cell-permeable photocross-linking probe. Ac4ManNDAz can effectively compete with endogenous sialic acid for incorporation into cell surface glycoproteins and form cross-links with glycoprotein ligands under UV light irradiation. Ac4ManNDAz can be used to study interactions between glycoproteins .

HY-140343

Ac4GalNAl	PROTAC Linkers	Cancer
Ac4GalNAl is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . Ac4GalNAl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-141136

Ac4GlcNAlk	PROTAC Linkers	Cancer
Ac4GlcNAlk is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-161913

AC-4-248	Dopamine Transporter	Neurological Disease
AC-4-248 is an atypical non-competitive dopamine transporter (DAT) inhibitor and reduces the potency of cocaine to inhibit DAT. AC-4-248 is a non-selective inhibitor of SLC6 transporters with IC₅₀ values for hDAT, hSERT, and hNET of 45.5 μM, 96.2 μM, and 250 μM, respectively .

HY-W415798

Ac4GalNAlk	Endogenous Metabolite	Others
Ac4GalNAlk is a weakly alkyne-labeled reagent for metabolic oligosaccharide engineering (MOE) that can be used to detect protein glycosylation. MOE reagents can be activated by cellular biosynthetic machinery into nucleotide sugars, which can be further traced through the introduction of glycoproteins in bioorthogonal chemistry. Ac4GalNAlk promotes nucleotide-sugar biosynthesis and increases bioorthogonal cell surface markers .

HY-111815A

N4-Acetylcytidine triphosphate sodium 1 Publications Verification AC4CTP sodium	Endogenous Metabolite	Others
N4-Acetylcytidine triphosphate sodium is efficiently used as a substrate in T7 Polymerase-catalyzed in vitro transcription and it can be incorporated into multiple templates .

HY-111815

N4-Acetylcytidine triphosphate AC4CTP	Endogenous Metabolite	Metabolic Disease
N4-Acetylcytidine triphosphate is efficiently used as a substrate in T7 Polymerase-catalyzed in vitro transcription and can be incorporated into multiple templates .

HY-111815B

N4-Acetylcytidine triphosphate sodium (solution) AC4CTP sodium (solution)	Endogenous Metabolite	Others
N4-Acetylcytidine triphosphate sodium (solution) is an efficient substrate for T7 RNA polymerase-catalyzed transcription in vitro and can be incorporated into multiple templates .

HY-W129441

N-Acetyl-4-S-cysteaminylphenol N-AC-4-S-CAP	Others	Others
N-Acetyl-4-S-mercaptoaminophenol (N-Ac-4-S-CAP) is a compound that is selectively cytotoxic to melanocytes of black mouse hair follicles. It can cause 98% depigmentation of black mouse hair follicles. N-Ac-4-S-CAP can produce visible changes in hair follicle melanocytes 4 hours after intraperitoneal injection, including aggregation of melanin granules and nuclear condensation. Electron microscopy observations showed that it caused progressive destruction of melanocytes, including swelling of membranous organelles, nuclear condensation, and cytoplasmic vacuolation, ultimately leading to complete cell necrosis. N-Ac-4-S-CAP has a specific cytotoxic effect on melanocytes that actively produce eumelanin, but may not affect precursor or dormant melanocytes. These properties suggest that N-Ac-4-S-CAP may have potential application value in the treatment of melanoma or skin whitening.

HY-W145646

*Fmoc-L-Ser((Ac)4-β-D-Glc)-OH*	Biochemical Assay Reagents	Others
Fmoc-L-Ser((Ac)4-β-D-Glc)-OH is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P4688

*(Ser(Ac)4,D-Ser(tBu)6,Azagly10)-LHRH*	GnRH Receptor	Endocrinology
(Ser(Ac)4,D-Ser(tBu)6,Azagly10)-LHRH is an important peptide hormone .

HY-N9459

2-Amino-2-deoxyglucose hydrochloride	Others	Others
2-Amino-2-deoxyglucose hydrochloride is a hexosamine hydrochloride can be used in the synthesis of cyclopropene-modified hexosamine derivative Ac4GlcNCyoc and Ac4GalNCyoc .

HY-W114327

N4-Acetyl-2'-O-methylcytidine	DNA/RNA Synthesis	Others
N4-Acetyl-2'-O-methylcytidine (ac4Cm) is an RNA with dual acetylation and methoxidation modifications found in thermophilic archaea. N4-Acetyl-2'-O-methylcytidine has been implicated in the adaptability of archaea in extreme environments, enhancing RNA stability through dual modification .

Cat. No.	Product Name	Type

HY-W145646

*Fmoc-L-Ser((Ac)4-β-D-Glc)-OH*	Biochemical Assay Reagents
Fmoc-L-Ser((Ac)4-β-D-Glc)-OH is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Cat. No.	Product Name	Target	Research Area

HY-P4688

*(Ser(Ac)4,D-Ser(tBu)6,Azagly10)-LHRH*	GnRH Receptor	Endocrinology
(Ser(Ac)4,D-Ser(tBu)6,Azagly10)-LHRH is an important peptide hormone .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-111815A

N4-Acetylcytidine triphosphate sodium 1 Publications Verification AC4CTP sodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
N4-Acetylcytidine triphosphate sodium is efficiently used as a substrate in T7 Polymerase-catalyzed in vitro transcription and it can be incorporated into multiple templates .

HY-N9459

2-Amino-2-deoxyglucose hydrochloride	Microorganisms Classification of Application Fields Source classification Other Diseases Disease Research Fields Saccharides	Others
2-Amino-2-deoxyglucose hydrochloride is a hexosamine hydrochloride can be used in the synthesis of cyclopropene-modified hexosamine derivative Ac4GlcNCyoc and Ac4GalNCyoc .

HY-W415798

Ac4GalNAlk	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Ac4GalNAlk is a weakly alkyne-labeled reagent for metabolic oligosaccharide engineering (MOE) that can be used to detect protein glycosylation. MOE reagents can be activated by cellular biosynthetic machinery into nucleotide sugars, which can be further traced through the introduction of glycoproteins in bioorthogonal chemistry. Ac4GalNAlk promotes nucleotide-sugar biosynthesis and increases bioorthogonal cell surface markers .

HY-111815

N4-Acetylcytidine triphosphate AC4CTP	Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
N4-Acetylcytidine triphosphate is efficiently used as a substrate in T7 Polymerase-catalyzed in vitro transcription and can be incorporated into multiple templates .

Cat. No.	Compare	Product Name	Species	Source

HY-P72328

	H2AC4 Protein, Human " Histone H2A type 1-B/E; Histone H2A.2; Histone H2A/a; Histone H2A/m; H2AFM"	Human	E. coli
	The H2AC4 protein is a core component of nucleosomes, which compress DNA into chromatin and restrict DNA entry into cellular processes. H2AC4 Protein, Human is the recombinant human-derived H2AC4 protein, expressed by E. coli , with tag free. The total length of H2AC4 Protein, Human is 129 a.a., with molecular weight of ~14.0 kDa.

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Cat. No.	Product Name		Classification

HY-118297

Ac4ManNAz (80% α isomer) 2 Publications Verification		Labeling and Fluorescence Imaging Azide
Ac4ManNAz is an azido-containing metabolic glycoprotein labeling reagent. Ac4ManNAz can be used to selectively modify proteins. Ac4ManNAz can be used in cell labeling, tracking and proteomic analysis . Ac4ManNAz is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-141128

Ac4GalNAz		Azide PROTAC Synthesis
Ac4GalNAz is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . Ac4GalNAz is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-140343

Ac4GalNAl		PROTAC Synthesis Alkynes
Ac4GalNAl is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . Ac4GalNAl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-141136

Ac4GlcNAlk		Alkynes
Ac4GlcNAlk is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-W415798

Ac4GalNAlk		Alkynes
Ac4GalNAlk is a weakly alkyne-labeled reagent for metabolic oligosaccharide engineering (MOE) that can be used to detect protein glycosylation. MOE reagents can be activated by cellular biosynthetic machinery into nucleotide sugars, which can be further traced through the introduction of glycoproteins in bioorthogonal chemistry. Ac4GalNAlk promotes nucleotide-sugar biosynthesis and increases bioorthogonal cell surface markers .

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Biochemical Assay Reagents

Peptides

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Recombinant Proteins

Click Chemistry

AC4

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Biochemical Assay Reagents

Peptides

NaturalProducts

Recombinant Proteins

Click Chemistry

Natural
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