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Results for "

ACC

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetyl-CoA Carboxylase (18) Adrenergic Receptor (1) AMPK (2) Antibiotic (1) Bacterial (3) Biochemical Assay Reagents (1) E3 Ligase Ligand-Linker Conjugates (1) EAAT (1) Epigenetic Reader Domain (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Isotope-Labeled Compounds (1) Ligands for E3 Ligase (1) Mitochondrial Metabolism (1) Monocarboxylate Transporter (2) Motilin Receptor (1) PDGFR (1) PROTACs (1) Proteasome (3) Small Interfering RNA (siRNA) (1) Trk Receptor (1) VEGFR (1)
By Research Areas:	Cancer (12) Cardiovascular Disease (1) Infection (6) Inflammation/Immunology (5) Metabolic Disease (12) Neurological Disease (4)
Oligonucleotides:	Aptamers (1) Pre-designed siRNA Sets (1) CpG ODNs (1) siRNAs (1)

Inhibitors & Agonists

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Acetyl-CoA Carboxylase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19624

*NVP-ACC789* ACC-789; ZK202650	VEGFR PDGFR	Cancer
NVP-ACC789 is an inhibitor of human VEGFR-1, VEGFR-2 (mouse VEGFR-2), VEGFR-3 and PDGFR-β with IC₅₀s of 0.38, 0.02 (0.23), 0.18, 1.4 μM, respectively.

HY-161976

ACC1-IN-2	Acetyl-CoA Carboxylase	Inflammation/Immunology
ACC1-IN-2 (Compound 16) is an *ACC1* inhibitor with an IC₅₀ of 7.3 nM. ACC1-IN-2 can be used in the study of acne .

HY-147930

ACC1/2-IN-1	Acetyl-CoA Carboxylase	Cancer
ACC1/2-IN-1 (compound 4s) is a potent *ACC1/2* inhibitor with IC₅₀ values of 98.06 and 29.43 nM for ACC1 and ACC2, respectively. ACC1/2-IN-1 can be used for cancer research .

HY-147932

ACC1/2-IN-2	Acetyl-CoA Carboxylase	Cancer
ACC1/2-IN-2 (compound PF-3) is a potent *ACC1/2* inhibitor with IC₅₀ values of 22 and 48 nM for ACC1 and ACC2, respectively. ACC1/2-IN-2 has antiproliferation activity and can be used for cancer research .

HY-E70227

Cathepsin G, human neutrophils CTSH; ACC4; ACC5	Others	Inflammation/Immunology
Cathepsin G, human neutrophils (CTSH; ACC4) a serine protease found in polymorphonuclear neutrophils (PMNs), functions in inflammation .

HY-127128

Flestolol sulfate ACC-9089 sulfate	Adrenergic Receptor	Neurological Disease
Flestolol (ACC-9089) sulfate is a competitive, ultra-short-acting beta-adrenergic blocking agent. Flestolol sulfate shows a half-life of approximately 6.5 minutes. Flestolol sulfate has the potential for the research of chest pain .

HY-RS00146

ACCS Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ACCS Human Pre-designed siRNA Set A contains three designed siRNAs for ACCS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ACCS Human Pre-designed siRNA Set A ACCS Human Pre-designed siRNA Set A

HY-151931

JA-ACC Jasmonyl-ACC	Others	Metabolic Disease
JA-ACC (Jasmonyl-ACC) is a derivative of 1-aminocyclopropane-1-carboxylic acid (ACC). ACC is the direct precursor of the plant hormone ethylene. JA-ACC inhibits root growth in Arabidopsis and the inhibition is independent of jasmonic acid (JA) signaling .

HY-169008

*PROTAC ACC* degrader-1**	Acetyl-CoA Carboxylase PROTACs	Infection
PROTAC ACC degrader-1 (Compound 9b) is a Acetyl-CoA Carboxylase degrader. PROTAC ACC degrader-1 exhibits superior potency against Aphis craccivora (IC₅₀ = 107.8 μg/mL). (Srtucture Note: Pink, Target protein ligand (HY-169009); Blue, E3 ligand (HY-163440); Black, linker (HY-W007559) .

HY-151931S

*JA-ACC-d3* Jasmonyl-ACC-d₃	Isotope-Labeled Compounds	Others
JA-ACC-d₃ is deuterium labeled JA-ACC[1].

HY-D0713

7ACC2 5+ Cited Publications	Monocarboxylate Transporter Mitochondrial Metabolism	Cancer
7ACC2 is a potent monocarboxylate transporter (MCT) inhibitor with an IC₅₀ of 11 nM for inhibition of [ ¹⁴C]-lactate influx. 7ACC2 is also a potent inhibitor of mitochondrial pyruvate transport. 7ACC2 is an anticancer agent through inhibition of lactate flux .

HY-P10003

iso-VQA-ACC	Proteasome	Cancer
iso-VQA-ACC is a substrate for constitutive proteasome .

HY-P10002

EWFW-ACC	Proteasome	Cancer
EWFW-ACC is the tetrapeptide substrate for the immunoproteasome and has selectivity for the LMP7 subunits .

HY-P10003A

*iso-VQA-ACC* TFA**	Proteasome	Others
iso-VQA-ACC TFA is a constitutive proteasome substrate .

HY-P10002A

*EWFW-ACC* TFA**	Biochemical Assay Reagents	Others
EWFW-ACC TFA is a specific immunoproteasome substrate that can be used to study immunoproteasome function .

HY-16946

CP-610431	Acetyl-CoA Carboxylase	Metabolic Disease
CP-610431 is a reversible, ATP-uncompetitive, isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor. CP-610431 inhibits *ACC1* and *ACC2* with IC₅₀s of ~50 nM. CP-610431 can be used for the research of metabolic syndrome .

HY-148684

AMPK activator 10	AMPK	Metabolic Disease
AMPK activator 10 is an orally active, potent AMPK activator with EC₁₅₀ of 44.3 nM by cell-ELISA. AMPK activator 10 increases the phosphorylation levels of ACC. AMPK activator 10 exhibits a glucose lowering effect .

HY-D0067

7ACC1 5+ Cited Publications DEAC; Coumarin D 1421; D 1421	Monocarboxylate Transporter	Cancer
7ACC1 (DEAC; Coumarin D 1421; D 1421) can selectively interfere with lactate flux in the tumor microenvironment and inhibit the influx of lactate in tumor cells expressing MCT1 and MCT4, but has no effect on lactate efflux.

HY-12942

PF-05175157 1 Publications Verification	Acetyl-CoA Carboxylase	Metabolic Disease
PF-05175157 is broad spectrum acetyl-CoA carboxylase (ACC) inhibitor with IC₅₀s of 27.0, 33.0, 23.5 and 50.4 nM for ACC1 (human), ACC2 (human), ACC1 (rat), ACC2 (rat), respectively.

HY-147376

hACC2-IN-1	Acetyl-CoA Carboxylase	Metabolic Disease
hACC2-IN-1 is a potent acetyl-CoA carboxylase 2 (ACC2) inhibitor, with an IC₅₀ value of 2.5 μM (hACC2). hACC2-IN-1 could be used for obesity research .

HY-16901

Firsocostat Maximum Cited Publications 13 Publications Verification ND-630; GS-0976; NDI-010976	Acetyl-CoA Carboxylase	Metabolic Disease
Firsocostat (ND-630; GS-0976; NDI-010976) is an acetyl-CoA carboxylase (ACC) inhibitor; inhibits human ACC1 and ACC2 with IC₅₀ values of 2.1 and 6.1 nM, respectively.

HY-107709

MK-4074 4 Publications Verification	Acetyl-CoA Carboxylase	Metabolic Disease
MK-4074 is a liver-specific inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC₅₀ values of approximately 3 nM.

HY-15259A

CP-640186 hydrochloride 5+ Cited Publications	Acetyl-CoA Carboxylase	Metabolic Disease
CP-640186 hydrochloride is an orally active and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC₅₀s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA. CP-640186 hydrochloride can also stimulate muscle fatty acid oxidation .

HY-15259

CP-640186 5+ Cited Publications	Acetyl-CoA Carboxylase	Metabolic Disease
CP-640186 is an orally active and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC₅₀s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA. CP-640186 can also stimulate muscle fatty acid oxidation .

HY-17641

Olumacostat glasaretil DRM01	Acetyl-CoA Carboxylase	Others
Olumacostat glasaretil (DRM01) is a small molecule inhibitor of acetyl coenzyme A carboxylase (ACC).

HY-106258

Atilmotin OHM 11638; BAX-ACC 1638; MOT 288	Motilin Receptor	Metabolic Disease
OHM 11638 (Atilmotin), an analogue of the (1-14) fragment of porcine motilin, is a motilin receptor agonist with a pK_d of 8.94 for the motilin receptor. OHM 11638 affects esophageal, lower esophageal sphincter (LES), and gastric motility. OHM 11638 increases LES and gastric pressures, OHM 11638 can be used as prokinetic agents .

HY-16901A

Firsocostat (S enantiomer) ND-630 (S enantiomer); GS-0976 (S enantiomer); NDI-010976 (S enantiomer)	Acetyl-CoA Carboxylase	Others
Firsocostat S enantiomer (ND-630 S enantiomer) is the less active S enantiomer of Firsocostat. Firsocostat is an acetyl-CoA carboxylase (ACC) inhibitor.

HY-16943

Moiramide B	Bacterial Acetyl-CoA Carboxylase	Infection
Moiramide B is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC₅₀ value of 6 nM. Moiramide B has antibacterial activity .

HY-147004

A-908292	Acetyl-CoA Carboxylase	Metabolic Disease
A-908292 is a potent and selective acetyl-CoA carboxylase 2 (ACC2) inhibitor, with an IC₅₀ of 23 nM for human ACC2. A-908292 can be used for the research of fatty acid metabolism . A-908292 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-144701

SABA1	Antibiotic Bacterial	Infection Inflammation/Immunology
SABA1 possesses antibacterial properties against Pseudomonas aeruginosa and Escherichia coli, with an IC₅₀ of 4.0 µM against E. coli ACC .

HY-152117

Acetyl-CoA Carboxylase-IN-1	Acetyl-CoA Carboxylase Bacterial	Infection
Acetyl-CoA Carboxylase-IN-1 is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC₅₀ value of ＜5 nM. Acetyl-CoA Carboxylase-IN-1 has antibacterial activity .

HY-101842

ND-646 5+ Cited Publications	Acetyl-CoA Carboxylase	Cancer
ND-646 is an orally bioavailable and steric inhibitor of acetyl-CoA carboxylase (ACC) with IC₅₀s of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively.

HY-100771

PCC0208009	Indoleamine 2,3-Dioxygenase (IDO)	Cardiovascular Disease
PCC0208009 is a potent IDO inhibitor with an IC₅₀ value of 4.52 nM in HeLa cell. PCC0208009 alleviates neuropathic pain and comorbidities by regulating synaptic plasticity of anterior cingulate cortex (ACC) and amygdala .

HY-120904

AMPK-IN-1	AMPK	Metabolic Disease
AMPK-IN-1 is an activator of AMPK (EC₅₀: 551 nM for isoform α2β2γ1). AMPK-IN-1 leads to eEF2 phosphorylation in a mTORC1-independent way .

HY-169010

Pomalidomide-CO-C5-Br	E3 Ligase Ligand-Linker Conjugates	Infection
Pomalidomide-CO-C5-Br (Compound 6b) is a conjugated compound of the E3 ligand Pomalidomide and linker. It can be used to synthesize highly effective PROTAC molecules targeting ADC (HY-169008) .

HY-169009

(Rac)-Spirotetramat-enol	Ligands for E3 Ligase	Infection
(Rac)-Spirotetramat-enol (Compound 8) is a target protein ligand that is used to synthesize PROTAC ADC degrader (HY-169008) .

HY-12741

LDN-212320 4 Publications Verification LDN-0212320; OSU-0212320	EAAT	Neurological Disease
LDN-212320 (LDN-0212320) is a glutamate transporter (GLT-1)/excitatory amino acid transporter 2 (EAAT2) activator (at translational level). LDN-212320 (LDN-0212320) prevents nociceptive pain by upregulating astroglial GLT-1 expression in the hippocampus and ACC ^[1]

HY-153367

FHD-609	Epigenetic Reader Domain	Cancer
FHD-609 is an inhibitor and a degrader of BRD9 (bromodomain-containing protein 9). FHD-609 targets to ncBAF, can be used for research of wide range of cancers that contain a mutation in a BAF complex subunit. FHD-609 in combination with Telomelysin or INO5401, may play a role in adrenocortical carcinoma (ACC) treatment .

HY-135981

CMS-121 1 Publications Verification	Acetyl-CoA Carboxylase	Neurological Disease Inflammation/Immunology
CMS-121 is a quinolone derivative and an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage with EC₅₀ values of 7 nM and 200 nM, respectively. CMS-121 has strong neuroprotective, anti-inflammatory, antioxidative and renoprotective activities .

HY-102066

Utatrectinib AZD-7451	Trk Receptor	Cancer
Utatrectinib (AZD-7451) is a potent, selective and orally active Trk inhibitor. Utatrectinib blocks TrkC activation and associated tumorigenic behaviors .

Cat. No.	Product Name	Target	Research Area

HY-P10003

iso-VQA-ACC	Proteasome	Cancer
iso-VQA-ACC is a substrate for constitutive proteasome .

HY-P10002

EWFW-ACC	Proteasome	Cancer
EWFW-ACC is the tetrapeptide substrate for the immunoproteasome and has selectivity for the LMP7 subunits .

HY-P10003A

*iso-VQA-ACC* TFA**	Proteasome	Others
iso-VQA-ACC TFA is a constitutive proteasome substrate .

HY-P10002A

*EWFW-ACC* TFA**	Biochemical Assay Reagents	Others
EWFW-ACC TFA is a specific immunoproteasome substrate that can be used to study immunoproteasome function .

HY-106258

Atilmotin OHM 11638; BAX-ACC 1638; MOT 288	Motilin Receptor	Metabolic Disease
OHM 11638 (Atilmotin), an analogue of the (1-14) fragment of porcine motilin, is a motilin receptor agonist with a pK_d of 8.94 for the motilin receptor. OHM 11638 affects esophageal, lower esophageal sphincter (LES), and gastric motility. OHM 11638 increases LES and gastric pressures, OHM 11638 can be used as prokinetic agents .

Cat. No.	Product Name

HY-KE7017

Fsp I
MCE Fsp I is a restriction enzyme for rapid DNA digestion, including plasmid, genomic DNA as well as PCR products. Isoschizomers: Acc16 I，Nsb I.

HY-KE7022

Kpn I
MCE Kpn I is a restriction enzyme for rapid DNA digestion, including plasmid, genomic DNA as well as PCR products. Isoschizomers: Asp718 I, Acc65 I.

Cat. No.	Product Name	Target	Research Area

HY-P99527

Vanutide cridificar ACC-001; PF 05236806	Inhibitory Antibodies	Neurological Disease
Vanutide cridificar (ACC-001) is an aminoterminal Aβ1-7 peptide conjugate. Vanutide cridificar can be used for Alzheimer's disease (AD) research .

Species:	Mouse (1) Rat (1)
Tag:	His (1) Tag Free (1)
Source:	HEK293 (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P7752

	Cathepsin H Protein, Mouse (HEK293, His) rMuCathepsin H, His; Pro-cathepsin H; CTSH; ACC-4; ACC-5; aleurain; cathepsin B3; cathepsin BA; cathepsin H; CPSB;	Mouse	HEK293
	Cathepsin H Protein, Mouse (HEK293, His) is an approximately 36-40 kDa cathepsin H protein with a His-flag. Cathepsin H is a lysosomal cysteine protease of the papain family.

HY-P79193

	Fractalkine/CX3CL1 Protein, Rat Fractalkine; Cx3cl1; C-X3-C motif chemokine 1; CX3C membrane-anchored chemokine; Neurotactin; Small-inducible cytokine D1; ACC1; Fkn; Scyd1	Rat	E. coli
	Fractalkine/CX3CL1 protein is a versatile chemokine that acts as a ligand for CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1. It regulates immune response, inflammation, adhesion, and chemotaxis. It activates integrins via CX3CR1-dependent and -independent pathways, binding to site 1 with CX3CR1 and site 2 without CX3CR1. Soluble Fractalkine/CX3CL1 attracts T-cells and monocytes, not neutrophils. Fractalkine/CX3CL1 Protein, Rat is the recombinant rat-derived Fractalkine/CX3CL1 protein, expressed by E. coli , with tag free. The total length of Fractalkine/CX3CL1 Protein, Rat is 79 a.a., with molecular weight of ~11 kDa.

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HY-P80787

	Phospho-Acetyl Coenzyme A Carboxylase (Ser79) Antibody ACACA; ACAC; ACC1; ACCA; Acetyl-CoA carboxylase 1; ACC1; ACC-alpha	WB	Human
	Phospho-Acetyl Coenzyme A Carboxylase (Ser79) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 266 kDa, targeting to Phospho-Acetyl Coenzyme A Carboxylase (Ser79). It can be used for WB assays with tag free, in the background of Human.

HY-P80482

	*Acetyl CoA Carboxylase 1 (ACC1) Antibody*	WB, IHC-P	Human, Mouse
	Acetyl CoA Carboxylase 1 (ACC1) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 266 kDa, targeting to Acetyl CoA Carboxylase 1(ACC1). It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse.

HY-P80528

	Acetyl Coenzyme A Carboxylase Antibody ACC; ACAC; ACC1; ACCA; ACACAD	WB, IHC-F, IHC-P, ICC/IF	Human
	Acetyl Coenzyme A Carboxylase Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 277 kDa, targeting to Acetyl Coenzyme A Carboxylase. It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human.

HY-P82998

	Bcl2 A1 Antibody (YA2743) BCL2A1; ACC-1; ACC-2; Bcl-2-like protein 5; Bcl-2-related protein A1; BCL2-related protein A1; BFL1; Bcl2-L-5; BCL2L5; GRS; HBPA1; Protein BFL-1; Protein GRS	WB, IHC-P, FC	Human, Mouse, Rat
	Bcl2 A1 Antibody (YA2743) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2743), targeting Bcl2 A1, with a predicted molecular weight of 20 kDa (observed band size: 27 kDa). Bcl2 A1 Antibody (YA2743) can be used for WB, IHC-P, FC experiment in human, mouse, rat background.

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Cat. No.	Product Name		Classification

HY-RS00146

ACCS Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
ACCS Human Pre-designed siRNA Set A contains three designed siRNAs for ACCS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-150214

ODN MT01		CpG ODNs
ODN MT01 was designed based on human mitochondrial DNA sequences, which is an inhibitory ODN that promotes osteocyte differentiation. ODN MT01 could promote osteoblast maturation and activation in rats, reduce rat alveolar bone absorption caused by periodontitis, regulate the expression levels of osteogenesis-related factors.

HY-148100

Emapticap pegol NOX-E36		Aptamers
Emapticap pegol is a inhibitor of pro-inflammatory chemokine C-C motif-ligand 2 (CCL2). Emapticap pegol is a 40-nucleotide oligonucleotide aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36) .

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