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Results for "

AKR1C3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	17β-HSD (8) Aldose Reductase (21) Androgen Receptor (1) Antibiotic (1) Bacterial (1) DNA Alkylator/Crosslinker (1) Drug Metabolite (1) E3 Ligase Ligand-Linker Conjugates (1) Endogenous Metabolite (1) Fluorescent Dye (1) GPR84 (1) Ligands for Target Protein for PROTAC (1) PPAR (1) Prostaglandin Receptor (1) PROTACs (1) RAR/RXR (1) Reactive Oxygen Species (2) Small Interfering RNA (siRNA) (1) Topoisomerase (1)
By Research Areas:	Cancer (31) Infection (1) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (2)
Click Chemistry:	Azide (1)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138557

AKR1C3-IN-4	17β-HSD	Cancer
AKR1C3-IN-4 is a potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC₅₀ of 0.56 μM. AKR1C3-IN-4 has the potential for castrate resistant prostate cancer (CRPC) research .

HY-RS00536

AKR1C3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AKR1C3 Human Pre-designed siRNA Set A contains three designed siRNAs for AKR1C3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AKR1C3 Human Pre-designed siRNA Set A AKR1C3 Human Pre-designed siRNA Set A

HY-163323

AKR1C3-IN-12	Aldose Reductase	Cancer
AKR1C3-IN-12 (compound 2j) is an aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC₅₀ of 27 nM. AKR1C3-IN-12 enhances the efficacy of Gemcitabine and Cisplatin in bladder cancer .

HY-144749

AKR1C3-IN-5	Aldose Reductase	Cancer
AKR1C3-IN-5 (Compound 6e) is a potent inhibitor of *AKR1C3. AKR1C3* enzyme is overexpressed in hormone-dependent prostate and breast tumors. AKR1C3-IN-5 derived from drupanin, which exhibits half-maximal inhibitory concentration (IC₅₀) of 9.6 ± 3 μM and selectivity index (SI) of 5.5 against MCF-7 cells .

HY-163784

AKR1C3-IN-14	Aldose Reductase	Cancer
AKR1C3-IN-14 (compound 4) is an *AKR1C3* inhibitor (IC₅₀=0.122 μM) that reduces the overproduction of androgens by inhibiting the activity of the *AKR1C3* enzyme, thereby regulating hormone-mediated signaling. AKR1C3-IN-14 also plays a role in the biosynthesis of the prostaglandin PGF2α, regulating cell proliferation by affecting this pathway. AKR1C3-IN-14 can be used in the study of prostate cancer .

HY-163610

AKR1C3-IN-13	Ligands for Target Protein for PROTAC Aldose Reductase	Cancer
AKR1C3-IN-13 (Compound 4) is an *AKR1C3* inhibitor. AKR1C3-IN-13 degrades AKR1C3 in prostate cancer cells .

HY-146573

AKR1C3-IN-6	Aldose Reductase 17β-HSD	Cancer
AKR1C3-IN-6 (Compound 1) is a potent, selective *AKR1C3* inhibitor with IC₅₀ values of 0.31 μM and 73.23 μM against AKR1C3 and AKR1C2, respectively. AKR1C3-IN-6 shows antitumor activity .

HY-146574

AKR1C3-IN-7	Aldose Reductase 17β-HSD	Cancer
AKR1C3-IN-7 (Compound 13) is a potent, selective *AKR1C3* inhibitor with an IC₅₀ of 0.19 μM. AKR1C3-IN-7 shows antitumor activity .

HY-146575

AKR1C3-IN-8	Aldose Reductase 17β-HSD	Cancer
AKR1C3-IN-8 (Compound 5) is a potent, selective *AKR1C3* inhibitor with an IC₅₀ of 0.069 μM. AKR1C3-IN-8 shows antitumor activity .

HY-157810

AKR1C3-IN-11	Aldose Reductase	Cancer
AKR1C3-IN-11 (Compound 6e) is a Aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC₅₀ of 2.0 μM. AKR1C3-IN-11 inhibit cell proliferation in combination with abiraterone (HY-70013). AKR1C3-IN-11 can be used for the research of prostate cancer .

HY-107379

AKR1C3-IN-1 1 Publications Verification	17β-HSD	Others
AKR1C3-IN-1 is a potent, highly selective inhibitor of *AKR1C3, with an IC₅₀* of 13 nM.

HY-155502

AKR1C3-IN-10	Aldose Reductase	Cancer
AKR1C3-IN-10 (compound 5r) is a selective *AKR1C3* inhibitor (IC₅₀=51 nM). AKR1C3-IN-10 shows good activity in a prostate cancer xenograft model .

HY-152188

AKR1C3-IN-9	Aldose Reductase	Cancer
AKR1C3-IN-9 is a selective inhibitor of Aldo-keto Reductase 1C3 (AKR1C3) with an IC₅₀ value of 8.92 nM. AKR1C3-IN-9 significantly reverses the Doxorubicin (HY-15142A) (DOX) resistance in a resistant breast cancer cell line .

HY-163609

*PROTAC AKR1C3* degrader-1**	PROTACs Aldose Reductase	Cancer
PROTAC AKR1C3 degrader-1 (compound 5) is a potent *AKR1C3* PROTAC degrader. PROTAC AKR1C3 degrader-1 decreases the protein expression of AKR1C3, AKR1C1/2, and ARv7. PROTAC AKR1C3 degrader-1 has the potential for the research of prostate cancer. (Blue:ubiquitin E3 ligase cereblon ligand (HY-A0003), Black: linker (HY-163647); Pink: AKR1C3 inhibitor (HY-163610)) .

HY-D1342

Coumberol	Fluorescent Dye	Cancer
Coumberol is a fluorescent substrate of AKR1C3 protein. Coumberol can be used for the research of AKR1C3 .

HY-W008567

N-Deschlorobenzoyl indomethacin	Drug Metabolite	Others
N-Deschlorobenzoyl indomethacin (Compound 18), the primary metabolite of indomethacin (HY-14397), lacks the N-p-chlorobenzoyl group in its structure. Consequently, N-Deschlorobenzoyl indomethacin loses inhibitory activity against AKR1C2 and *AKR1C3* (AKR1C2 IC₅₀ =100 μM, *AKR1C3* IC₅₀ >100 μM), exhibiting no selectivity .

HY-150646

S07-2009	Aldose Reductase	Cancer
S07-2009 is a potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC₅₀ value of 0.20 μM .

HY-150649

S07-2005 (racemic)	17β-HSD	Cancer
S07-2005 racemic is a potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC₅₀ value of 0.13 μM and 0.75 μM for AKR1C3 and AKR1C4, respectively. S07-2005 racemic has potential as a chemotherapeutic potentiator for cancer agent resistance .

HY-19903

ASP-9521 2 Publications Verification	17β-HSD	Cancer
ASP-9521 is a potent, selective and orally available *AKR1C3* inhibitor with an IC₅₀ of 11 nM for human AKR1C3.

HY-155035

S07-1066	17β-HSD	Cancer
S07-1066 is an aldo-keto reductase 1C3 (AKR1C3) inhibitor, synergizing doxorubicin (DOX) cytotoxicity. S07-1066 selectively blocks AKR1C3-mediated reduction of DOX, and reverses the DOX resistance in overexpressing AKR1C3 cells .

HY-W024692

Indomethacin methylester Indometacin methylester	Prostaglandin Receptor	Cancer
Indomethacin methylester (Compound 10; Indometacin methylester) is a potent and selective *AKR1C3* inhibitor with an IC₅₀ value of 5.67 μM. Indomethacin methylester is promising for research of postate cancer .

HY-171115

Pyrone-211	GPR84 Aldose Reductase	Metabolic Disease
Pyrone-211 is a potent GPR84 agonist and *AKR1C3* inhibitor. Pyrone-211 participates in an expanded polyamine pathway .

HY-109154

Obafistat	Aldose Reductase	Inflammation/Immunology
Obafistat is a potent aldo-keto reductase *AKR1C3* inhibitor with an IC₅₀ of 1.2 nM for human AKR1C3 (patent WO2017202817A1, example 4) .

HY-163940

LX1	Aldose Reductase Androgen Receptor	Cancer
LX1 is an anti-prostate cancer compound that targets androgen receptor (AR), AR variants and steroidogenic enzyme *AKR1C3. LX1 inhibits the enzymatic activity of AKR1C3, reduces the conversion of androstenedione to testosterone and reduces the expression of AR and AR-V7* and downregulates their target genes. LX1 overcomes the resistance of tumor cells to Enzalutamide (HY-70002), and the combination with Enzalutamide (HY-70002) further inhibits tumor growth .

HY-116170

SN34037	Aldose Reductase	Cancer
SN34037 is a specific inhibitor of Aldo-keto reductase 1C3 (AKR1C3, EC 1.1.1.188) with the ability to inhibit the cytotoxic activity of PR-104A. SN34037-sensitive coumberone reduction provides a rapid and specific assay for AKR1C3 activity. SN34037 inhibits the aerobic cytotoxicity of PR-104A in TF1 erythroleukemia cells with high AKR1C3 expression, but not in Nalm6 pre-B acute lymphoblastic leukemia cells with low AKR1C3 expression .

HY-152189

S19-1035	Others	Cancer
S19-1035 is a highly potent and specific aldo-keto reductase 1C3 (AKR1C3) inhibitor. S19-1035 inhibits AKR1C3 with an IC₅₀ value of 3.04 nM. S19-1035 can be used for the research of tumor .

HY-150648

S07-2008	Aldose Reductase	Cancer
S07-2008 is a selective aldo-keto reductase family 1 member C3 (AKR1C3) inhibitor with an IC₅₀ of 0.16 μM. S07-2008 shows anticancer activities .

HY-124573

OBI-3424 TH-3424	DNA Alkylator/Crosslinker	Cancer
OBI-3424 (TH-3424) is a proagent that is selectively converted by AKR1C3 (aldo-keto reductase 1C3) to a potent DNA-alkylating agent. OBI-3424 can be used for hepatocellular carcinoma, castrate-resistant prostate cancer, and acute lymphoblastic leukemia (ALL) research .

HY-150650

S07-2001	Aldose Reductase	Cancer
S07-2001 is a potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC₅₀ value of 2.08 μM. S07-2001 enhances the activity of Doxorubicin against cancer cells. S07-2001 has potential as a chemotherapeutic potentiator for cancer agent resistance .

HY-121656

AKR1C2/3-IN-2	Endogenous Metabolite	Cancer
AKR1C2/3-IN-2 is a potential AKR1C3 inhibitor with selective AKR1C3 activity. AKR1C2/3-IN-2 is able to block AKR1C3-mediated testosterone (T) production and PSA induction, affecting the endocrine activity of prostate cancer cells. AKR1C2/3-IN-2 shows selectivity over other AKR1C enzymes, indicating its potential application in inhibiting drug-resistant prostate cancer. AKR1C2/3-IN-2 has no inhibitory activity against COX isomerases, further emphasizing its specificity as a prostate cancer inhibitory compound .

HY-N10361

Drupanin	RAR/RXR PPAR Aldose Reductase	Cancer
Drupanin is an orally active and selective AKR1C3 enzyme inhibitor and an RXRα agonist with an EC₅₀ value of 4.8 μM, which is found in green propolis. Drupanin also activates PPARγ moderately. Drupanin induces adipogenesis and elevates aP2 mRNA levels in 3T3-L1 fibroblasts Drupanin has the potential for the research of breast and prostate cancers .

HY-161839

AKR1C2/3-IN-1	Aldose Reductase	Cancer
AKR1C2/3-IN-1 (compound 3a) is a potent AKR1C2 and *AKR1C3* inhibitor with IC₅₀ values of 90, 50 nM, respectively. AKR1C2/3-IN-1 can be used as a radiation sensitizer and as a potentiator of chemotherapy cytotoxicity .

HY-163647

Lenalidomide-COCH-PEG2-azido	E3 Ligase Ligand-Linker Conjugates	Cancer
Lenalidomide-COCH-PEG2-azido is a synthesized E3 ligase ligand-linker conjugate that incorporates the Lenalidomide (HY-A0003) based cereblon ligand and a linker. Lenalidomide-COCH-PEG2-azido can be used in the synthesis of PROTAC AKR1C3 degrader-1 (HY-163609) .

HY-150644

S07-2010 1 Publications Verification	Aldose Reductase	Cancer
S07-2010 is a potent pan-AKR1C (aldo-keto reductase family 1 member C) inhibitor, with IC₅₀ values of 0.19, 0.36, 0.47, and 0.73 μM for *AKR1C3, AKR1C4, AKR1C1* and AKR1C2, respectively. S07-2010 induces apoptosis in A549/DDP cells. S07-2010 strengthens the cytotoxicity of chemotherapeutic agents in drug-resistant cells. S07-2010 significantly inhibits the proliferation of drug-resistant cells .

HY-N0376

Liquiritin Maximum Cited Publications 7 Publications Verification	Reactive Oxygen Species	Neurological Disease Inflammation/Immunology Cancer
Liquiritin, a flavonoid isolated from Glycyrrhiza uralensis, is a potent and competitive AKR1C1 inhibitor with IC₅₀s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo . Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity .

HY-N0376R

Liquiritin (Standard)	Reactive Oxygen Species	Neurological Disease Inflammation/Immunology Cancer
Liquiritin (Standard) is the analytical standard of Liquiritin. This product is intended for research and analytical applications. Liquiritin, a flavonoid isolated from Glycyrrhiza uralensis, is a potent and competitive AKR1C1 inhibitor with IC50s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo . Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity .

HY-B0398AR

Nalidixic acid (sodium salt) (Standard)	Bacterial Antibiotic Topoisomerase	Infection
Liquiritin (Standard) is the analytical standard of Liquiritin. This product is intended for research and analytical applications. Liquiritin, a flavonoid isolated from Glycyrrhiza uralensis, is a potent and competitive AKR1C1 inhibitor with IC50s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo . Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity .

Drupanin	Monophenols Animals Classification of Application Fields Source classification Phenols Disease Research Fields Cancer	RAR/RXR PPAR Aldose Reductase
Drupanin is an orally active and selective AKR1C3 enzyme inhibitor and an RXRα agonist with an EC₅₀ value of 4.8 μM, which is found in green propolis. Drupanin also activates PPARγ moderately. Drupanin induces adipogenesis and elevates aP2 mRNA levels in 3T3-L1 fibroblasts Drupanin has the potential for the research of breast and prostate cancers .

Liquiritin 5+ Cited Publications	Structural Classification Neurological Disease Classification of Application Fields Source classification Plants Monophenols Flavonoids Leguminosae Flavonones Phenols Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields	Reactive Oxygen Species
Liquiritin, a flavonoid isolated from Glycyrrhiza uralensis, is a potent and competitive AKR1C1 inhibitor with IC₅₀s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo . Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity .

Liquiritin (Standard)	Structural Classification Monophenols Flavonoids Leguminosae Flavonones Source classification Phenols Plants Glycyrrhiza uralensis Fisch.	Reactive Oxygen Species
Liquiritin (Standard) is the analytical standard of Liquiritin. This product is intended for research and analytical applications. Liquiritin, a flavonoid isolated from Glycyrrhiza uralensis, is a potent and competitive AKR1C1 inhibitor with IC50s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo . Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity .

Cat. No.	Compare	Product Name	Species	Source

HY-P7604

	AKR1C3 Protein, Human (HEK293, His) rHuAKR1C3, His; AKR1C3; HA1753; Dihydrodiol Dehydrogenase Type I; Indanol Dehydrogenase; Prostaglandin F Synthase	Human	HEK293
	AKR1C3 Protein, Human (HEK293, His) expresses in HEK293 cells with a His tag. Aldo-keto reductase family 1 member C3 (AKR1C3) is a steroidogenic enzyme that plays a crucial role in the conversion of adrenal androgen dehydroepiandrosterone (DHEA) into high-affinity ligands for the androgen receptor (testosterone [T] and dihydrotestosterone [DHT]).

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HY-P82593

	AKR1C3 Antibody (YA2338) DD3; DDX; HA1753; HAKRB; HAKRe; HSD17B5; KIAA0119; hluPGFS	WB, ICC/IF, IP, FC	Human
	AKR1C3 Antibody (YA2338) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2338), targeting AKR1C3, with a predicted molecular weight of 37 kDa (observed band size: 37 kDa). AKR1C3 Antibody (YA2338) can be used for WB, ICC/IF, IP, FC experiment in human background.

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Cat. No.	Product Name		Classification

HY-163647

Lenalidomide-COCH-PEG2-azido		Azide
Lenalidomide-COCH-PEG2-azido is a synthesized E3 ligase ligand-linker conjugate that incorporates the Lenalidomide (HY-A0003) based cereblon ligand and a linker. Lenalidomide-COCH-PEG2-azido can be used in the synthesis of PROTAC AKR1C3 degrader-1 (HY-163609) .

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AKR1C3

Inhibitors & Agonists

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