ATP Citrate Lyase

By Targets:	ATP Citrate Lyase (15) AMPK (3) Autophagy (1) Bacterial (3) Endogenous Metabolite (3) Fatty Acid Synthase (FASN) (1) Free Fatty Acid Receptor (1) HIF/HIF Prolyl-Hydroxylase (3)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Infection (3) Inflammation/Immunology (3) Metabolic Disease (14)

Targets Recommended: ATP Citrate Lyase ATP Synthase P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16007

(-)-Hydroxycitric acid Garcinia acid	ATP Citrate Lyase	Metabolic Disease
(-)-Hydroxycitric acid (Garcinia acid) is the principal acid of fruit rinds of Garcinia cambogia. (-)-Hydroxycitric acid is a potent and competitive and orally active inhibitor of **ATP citrate lyase**. (-)-Hydroxycitric acid suppresses the fatty acid synthesis, lipogenesis, food intake, and induced weight loss .

HY-16450

SB 204990 10+ Cited Publications	ATP Citrate Lyase	Metabolic Disease
SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme.

HY-16107

BMS-303141 10+ Cited Publications	ATP Citrate Lyase	Metabolic Disease
BMS-303141 is a potent, cell-permeable ATP-citrate lyase (ACL) inhibitor with an IC₅₀ of 0.13 μM.

HY-12357

Bempedoic acid 10+ Cited Publications ETC-1002; ESP-55016	ATP Citrate Lyase AMPK	Metabolic Disease
Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor . Bempedoic acid (ETC-1002) activates AMPK .

HY-B1295

Lithium citrate tetrahydrate Maximum Cited Publications 26 Publications Verification Litarex tetrahydrate	ATP Citrate Lyase Bacterial HIF/HIF Prolyl-Hydroxylase Endogenous Metabolite	Infection Metabolic Disease Inflammation/Immunology Cancer
Lithium citrate (Litarex) tetrahydrate is the major active ingredient of Garcinia cambogia. Lithium citrate tetrahydrate competitively inhibits **ATP citrate lyase** with weight loss benefits. Lithium citrate tetrahydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects .

HY-127111

NDI-091143 2 Publications Verification	ATP Citrate Lyase	Cancer
NDI-091143 is a potent and high-affinity *human ATP-citrate* lyase (ACLY) inhibitor with an IC₅₀ of 2.1 nM (ADP-Glo assay), a K_i of 7.0 nM and a K_d of 2.2 nM. NDI-091143 inhibits ACLY** catalysis allosterically, by stabilizing large conformational changes in the citrate domain that indirectly block the binding and recognition of citrate .

HY-12357S2

Bempedoic acid-d4 ETC-1002-d₄; ESP-55016-d₄	ATP Citrate Lyase AMPK	Others
Bempedoic acid-d₄ is the deuterium labeled Bempedoic acid. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor. Bempedoic acid (ETC-1002) activates AMPK[1][2].

HY-N12336

Gnetuhainin I	Others	Metabolic Disease
Gnetuhainin I (Compound 5) is a lignin derived from Pouzolzia zeylanica. Gnetuhainin I shows good inhibitory effect on ATP citrate lyase (ACLY) (IC₅₀=2.63 μM) .

HY-N11781

Forrestiacids J	ATP Citrate Lyase	Metabolic Disease
Forrestiacids J is an ATP-citrate lyase (ACL) inhibitor with an IC₅₀ of 2.6 μM .

HY-N11782

Forrestiacids K	ATP Citrate Lyase	Others
Forrestiacids K, a terpenoid isolated from Pseudotsuga forrestii, acts as an ATP-citrate lyase (ACL) inhibitor .

HY-N7347

(-)-Hydroxycitric acid lactone Garcinia lactone	ATP Citrate Lyase	Metabolic Disease
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of **ATP-citrate lyase*. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate* to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .

HY-W009156

Citric acid tripotassium hydrate Maximum Cited Publications 26 Publications Verification Potassium Citrate monohydrate	ATP Citrate Lyase HIF/HIF Prolyl-Hydroxylase Bacterial Endogenous Metabolite	Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) is the major active ingredient of Garcinia cambogia. Hydroxycitric acid tripotassium hydrate competitively inhibits **ATP citrate lyase with weight loss benefits. Hydroxycitric acid tripotassium hydrate effective inhibits stones formation and also inhibits HIF**, and has antioxidation, anti-inflammation and anti-tumor effects .

HY-17640

Nicodicosapent	Fatty Acid Synthase (FASN) Autophagy	Metabolic Disease
Nicodicosapent is a fatty acid niacin conjugate that is also an inhibitor of the sterol regulatory element binding protein (SREBP), a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1.

HY-12357S

Bempedoic acid-d5 ETC-1002-d₅; ESP-55016-d₅	ATP Citrate Lyase AMPK	Metabolic Disease
Bempedoic acid-d₅ is the deuterium labeled Bempedoic acid[1]. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor[1]. Bempedoic acid (ETC-1002) activates AMPK[2].

HY-P1123

MEDICA16	ATP Citrate Lyase Free Fatty Acid Receptor	Metabolic Disease
MEDICA16, an **ATP-citrate lyase inhibitor, significantly reduces intracellular TG content in gastrocnemius muscle, and this reduction is accompanied by an increase in insulin sensitivity. MEDICA16 is a selective agonist for GPR40 as well as selective partial agonists for GPR120** .

HY-N7347R

(-)-Hydroxycitric acid lactone (Standard)	ATP Citrate Lyase	Metabolic Disease
(-)-Hydroxycitric acid lactone (Standard) is the analytical standard of (-)-Hydroxycitric acid lactone. This product is intended for research and analytical applications. (-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .

HY-W009156R

Citric acid tripotassium hydrate (Standard)	ATP Citrate Lyase HIF/HIF Prolyl-Hydroxylase Bacterial Endogenous Metabolite	Infection Metabolic Disease Inflammation/Immunology Cancer
Citric acid (tripotassium hydrate) (Standard) is the analytical standard of Citric acid (tripotassium hydrate). This product is intended for research and analytical applications. Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) is the major active ingredient of Garcinia cambogia. Hydroxycitric acid tripotassium hydrate competitively inhibits ATP citrate lyase with weight loss benefits. Hydroxycitric acid tripotassium hydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects .

Cat. No.	Product Name	Type

HY-B1295

Lithium citrate tetrahydrate 25+ Cited Publications Litarex tetrahydrate	Biochemical Assay Reagents
Lithium citrate (Litarex) tetrahydrate is the major active ingredient of Garcinia cambogia. Lithium citrate tetrahydrate competitively inhibits **ATP citrate lyase** with weight loss benefits. Lithium citrate tetrahydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-16007

(-)-Hydroxycitric acid Garcinia acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Guttiferae Metabolic Disease Plants Garcinia cambogia Disease Research Fields	ATP Citrate Lyase
(-)-Hydroxycitric acid (Garcinia acid) is the principal acid of fruit rinds of Garcinia cambogia. (-)-Hydroxycitric acid is a potent and competitive and orally active inhibitor of **ATP citrate lyase**. (-)-Hydroxycitric acid suppresses the fatty acid synthesis, lipogenesis, food intake, and induced weight loss .

HY-B1295

Lithium citrate tetrahydrate 25+ Cited Publications Litarex tetrahydrate	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	ATP Citrate Lyase Bacterial HIF/HIF Prolyl-Hydroxylase Endogenous Metabolite
Lithium citrate (Litarex) tetrahydrate is the major active ingredient of Garcinia cambogia. Lithium citrate tetrahydrate competitively inhibits **ATP citrate lyase** with weight loss benefits. Lithium citrate tetrahydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects .

HY-N7347

(-)-Hydroxycitric acid lactone Garcinia lactone	Structural Classification other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Plants Disease Research Fields	ATP Citrate Lyase
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of **ATP-citrate lyase*. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate* to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .

HY-W009156

Citric acid tripotassium hydrate 25+ Cited Publications Potassium Citrate monohydrate	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Guttiferae Metabolic Disease Plants Garcinia cambogia Inflammation/Immunology Disease Research Fields	ATP Citrate Lyase HIF/HIF Prolyl-Hydroxylase Bacterial Endogenous Metabolite
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) is the major active ingredient of Garcinia cambogia. Hydroxycitric acid tripotassium hydrate competitively inhibits **ATP citrate lyase with weight loss benefits. Hydroxycitric acid tripotassium hydrate effective inhibits stones formation and also inhibits HIF**, and has antioxidation, anti-inflammation and anti-tumor effects .

HY-N12336

Gnetuhainin I	Structural Classification Urticaceae Pouzolzia zeylanica (L.) Benn. Source classification Phenols Polyphenols Plants	Others
Gnetuhainin I (Compound 5) is a lignin derived from Pouzolzia zeylanica. Gnetuhainin I shows good inhibitory effect on ATP citrate lyase (ACLY) (IC₅₀=2.63 μM) .

HY-N11781

Forrestiacids J	Triterpenes Structural Classification Classification of Application Fields Pinaceae Terpenoids Source classification Metabolic Disease Plants Pseudotsuga forrestii Craib Disease Research Fields	ATP Citrate Lyase
Forrestiacids J is an ATP-citrate lyase (ACL) inhibitor with an IC₅₀ of 2.6 μM .

HY-N11782

Forrestiacids K	Structural Classification Pinaceae Terpenoids Source classification Diterpenoids Plants Pseudotsuga forrestii Craib	ATP Citrate Lyase
Forrestiacids K, a terpenoid isolated from Pseudotsuga forrestii, acts as an ATP-citrate lyase (ACL) inhibitor .

HY-N7347R

(-)-Hydroxycitric acid lactone (Standard)	Structural Classification other families Ketones, Aldehydes, Acids Source classification Plants	ATP Citrate Lyase
(-)-Hydroxycitric acid lactone (Standard) is the analytical standard of (-)-Hydroxycitric acid lactone. This product is intended for research and analytical applications. (-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .

HY-W009156R

Citric acid tripotassium hydrate (Standard)	Structural Classification Ketones, Aldehydes, Acids Guttiferae Plants Garcinia cambogia	ATP Citrate Lyase HIF/HIF Prolyl-Hydroxylase Bacterial Endogenous Metabolite
Citric acid (tripotassium hydrate) (Standard) is the analytical standard of Citric acid (tripotassium hydrate). This product is intended for research and analytical applications. Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) is the major active ingredient of Garcinia cambogia. Hydroxycitric acid tripotassium hydrate competitively inhibits ATP citrate lyase with weight loss benefits. Hydroxycitric acid tripotassium hydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects .

Cat. No.	Compare	Product Name	Species	Source

HY-P72070

	ACLY Protein, Human (His-SUMO) ACL; Acly; ACLY_HUMAN; ATP Citrate pro-S; Lyase; ATP Citrate Lyase; ATP Citrate synthase; ATP-Citrate pro-S-; -Lyase; ATP-Citrate synthase; ATPCitrate synthase; ATPCL; Citrate cleavage enzyme; CLATP; OTTHUMP00000164773	Human	E. coli
	ACLY Protein, Human (His-SUMO) is an important enzyme in the cholesterol biosynthetic pathway. ACLY produces acetyl-CoA (AcCoA) from mitochondrial citrate for cholesterol and fatty acid biosynthesis.

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Cat. No.	Product Name	Chemical Structure

HY-12357S2

Bempedoic acid-d4
Bempedoic acid-d₄ is the deuterium labeled Bempedoic acid. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor. Bempedoic acid (ETC-1002) activates AMPK[1][2].

HY-12357S

Bempedoic acid-d5
Bempedoic acid-d₅ is the deuterium labeled Bempedoic acid[1]. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor[1]. Bempedoic acid (ETC-1002) activates AMPK[2].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80380

	ATP citrate lyase Antibody	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse
	ATP citrate lyase Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 121 kDa, targeting to ATP citrate lyase. It can be used for WB,ICC/IF,IHC-P,IP,FC assays with tag free, in the background of Human, Mouse.

HY-P80560

	ATP Citrate Lyase Antibody (YA829) ACLY; ATP-Citrate synthase; ATP-Citrate; pro-S-)-Lyase; ACL; Citrate cleavage enzyme	WB, ICC/IF, FC	Human, Mouse, Monkey
	ATP Citrate Lyase Antibody (YA829) is a non-conjugated and Mouse origined monoclonal antibody about 121 kDa, targeting to ATP Citrate Lyase (3D9). It can be used for WB,ICC/IF,FC assays with tag free, in the background of Human, Mouse, Monkey.

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Inhibitors & Agonists

Biochemical Assay Reagents

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ATP Citrate Lyase

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Recombinant Proteins

Isotope-Labeled Compounds

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