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AngiotensinII (AngiotensinII) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. AngiotensinIIhuman plays a central role in regulating human blood pressure, which is mainly mediated by interactions between AngiotensinII and the G-protein-coupled receptors (GPCRs) AngiotensinII type 1 receptor (AT1R) and AngiotensinII type 2 receptor (AT2R). AngiotensinIIhuman stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. AngiotensinIIhuman induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. AngiotensinIIhuman also induces apoptosis. AngiotensinII induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .
AngiotensinIIhuman (AngiotensinII) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. AngiotensinIIhuman acetate plays a central role in regulating human blood pressure, which is mainly mediated by interactions between AngiotensinII and the G-protein-coupled receptors (GPCRs) AngiotensinII type 1 receptor (AT1R) and AngiotensinII type 2 receptor (AT2R). AngiotensinIIhuman acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. AngiotensinIIhuman acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. AngiotensinIIhuman acetate also induces apoptosis. AngiotensinIIhuman acetate induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .
AngiotensinIIhuman (AngiotensinII) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. AngiotensinIIhuman TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between AngiotensinII and the G-protein-coupled receptors (GPCRs) AngiotensinII type 1 receptor (AT1R) and AngiotensinII type 2 receptor (AT2R). AngiotensinIIhuman TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. AngiotensinIIhuman TFA induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. AngiotensinIIhuman TFA also induces apoptosis. AngiotensinIIhuman TFA induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .
AngiotensinIIhuman- 13C6, 15N TFA (Ang II- 13C6, 15N TFA) is 13C- and 15N-labeled AngiotensinIIhuman (TFA) (HY-13948B). AngiotensinIIhuman (AngiotensinII) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. AngiotensinIIhuman TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between AngiotensinII and the G-protein-coupled receptors (GPCRs) AngiotensinII type 1 receptor (AT1R) and AngiotensinII type 2 receptor (AT2R). AngiotensinIIhuman TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions .
AngiotensinII (5-8), human is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensinII . AngiotensinII binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca 2+ levels. AngiotensinII also acts at the Na +/H + exchanger in the proximal tubules of the kidney .
AngiotensinII (1-4), human is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). AngiotensinII binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca 2+ levels. AngiotensinII also acts at the Na +/H + exchanger in the proximal tubules of the kidney .
AngiotensinII (1-4), human (TFA) is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). AngiotensinII binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca 2+ levels. AngiotensinII also acts at the Na +/H + exchanger in the proximal tubules of the kidney .
Biotinyl-Angiotensin I (human, mouse, rat) is biotin-labeled Angiotensin I . Angiotensin I (human, mouse, rat) is the precursor to the vasoconstrictor peptide angiotensinII, cleaved by the angiotensin-converting enzyme (ACE) .
Angiotensin I-13C6,15N (human, mouse, rat) TFA is 13C and 15N labeled Angiotensin I (human, mouse, rat) TFA. Angiotensin I-13C6,15N (human, mouse, rat) TFA is a precursor of angiotensinII and is cleaved into angiotensinII by angiotensin converting enzyme (ACE) .
Eprosartan mesylate (SKF-108566J) is a selective, competitive, nonpeptid and orally active angiotensinII receptor antagonist, used as an antihypertensive. Eprosartan mesylate binds angiotensinII receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .
Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensinII receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensinII receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .
Eprosartan-d3 is the deuterium labeled Eprosartan. Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensinII receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensinII receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively [1].
Eprosartan (mesylate) (Standard) is the analytical standard of Eprosartan (mesylate). This product is intended for research and analytical applications. Eprosartan mesylate (SKF-108566J) is a selective, competitive, nonpeptid and orally active angiotensinII receptor antagonist, used as an antihypertensive. Eprosartan mesylate binds angiotensinII receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .
Eprosartan-d6 is deuterated labeled Eprosartan (HY-117743). Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensinII receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensinII receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .
Eprosartan (Standard) is the analytical standard of Eprosartan. This product is intended for research and analytical applications. Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensinII receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensinII receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .
Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensinII receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensinII-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure .
Losartan carboxylic acid-d4 (hydrochloride) is deuterium labeled Losartan Carboxylic Acid. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensinII receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensinII-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure[1][2][3][4].
Losartan Carboxylic Acid (Standard) is the analytical standard of Losartan Carboxylic Acid. This product is intended for research and analytical applications. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensinII receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensinII-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure [4].
AT2R antagonist 1 (compound 21) is a potent and high selective AT2R (angiotensinII AT2 receptor) ligand. AT2R antagonist 1 exhibits a fair AT2R affinity, with a Ki of 29 nM. AT2R antagonist 1 also inhibits common agent-metabolizing CYP enzymes. AT2R antagonist 1 shows high stability in human, rat and mouse liver microsomes .
AngiotensinII (AngiotensinII) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. AngiotensinIIhuman plays a central role in regulating human blood pressure, which is mainly mediated by interactions between AngiotensinII and the G-protein-coupled receptors (GPCRs) AngiotensinII type 1 receptor (AT1R) and AngiotensinII type 2 receptor (AT2R). AngiotensinIIhuman stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. AngiotensinIIhuman induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. AngiotensinIIhuman also induces apoptosis. AngiotensinII induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .
AngiotensinIIhuman (AngiotensinII) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. AngiotensinIIhuman acetate plays a central role in regulating human blood pressure, which is mainly mediated by interactions between AngiotensinII and the G-protein-coupled receptors (GPCRs) AngiotensinII type 1 receptor (AT1R) and AngiotensinII type 2 receptor (AT2R). AngiotensinIIhuman acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. AngiotensinIIhuman acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. AngiotensinIIhuman acetate also induces apoptosis. AngiotensinIIhuman acetate induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .
AngiotensinIIhuman (AngiotensinII) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. AngiotensinIIhuman TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between AngiotensinII and the G-protein-coupled receptors (GPCRs) AngiotensinII type 1 receptor (AT1R) and AngiotensinII type 2 receptor (AT2R). AngiotensinIIhuman TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. AngiotensinIIhuman TFA induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. AngiotensinIIhuman TFA also induces apoptosis. AngiotensinIIhuman TFA induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .
AngiotensinIIhuman, FAM-labeled (AngiotensinII, FAM-labeled ; Ang II, FAM-labeled ; DRVYIHPF, FAM-labeled) is a biological active peptide. (FAM labeled HY-13948)
AngiotensinII (5-8), human is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensinII . AngiotensinII binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca 2+ levels. AngiotensinII also acts at the Na +/H + exchanger in the proximal tubules of the kidney .
Biotin-Ahx-AngiotensinIIhuman (Biotin-Ahx-AngiotensinII; Biotin-Ahx-Ang II; Biotin-Ahx-DRVYIHPF) is a biological active peptide. (biotin labeled HY-13948)
AngiotensinII (1-4), human is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). AngiotensinII binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca 2+ levels. AngiotensinII also acts at the Na +/H + exchanger in the proximal tubules of the kidney .
AngiotensinII (1-4), human (TFA) is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). AngiotensinII binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca 2+ levels. AngiotensinII also acts at the Na +/H + exchanger in the proximal tubules of the kidney .
Biotinyl-Angiotensin I (human, mouse, rat) is biotin-labeled Angiotensin I . Angiotensin I (human, mouse, rat) is the precursor to the vasoconstrictor peptide angiotensinII, cleaved by the angiotensin-converting enzyme (ACE) .
Angiotensin I-13C6,15N (human, mouse, rat) TFA is 13C and 15N labeled Angiotensin I (human, mouse, rat) TFA. Angiotensin I-13C6,15N (human, mouse, rat) TFA is a precursor of angiotensinII and is cleaved into angiotensinII by angiotensin converting enzyme (ACE) .
AngiotensinII (AngiotensinII) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. AngiotensinIIhuman plays a central role in regulating human blood pressure, which is mainly mediated by interactions between AngiotensinII and the G-protein-coupled receptors (GPCRs) AngiotensinII type 1 receptor (AT1R) and AngiotensinII type 2 receptor (AT2R). AngiotensinIIhuman stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. AngiotensinIIhuman induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. AngiotensinIIhuman also induces apoptosis. AngiotensinII induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .
AGTR2 Protein, Human (Sf9, Flag, His) is the recombinant human-derived AGTR2, expressed by Sf9 insect cells , with His, Flag labeled tag. The total length of AGTR2 Protein, Human (Sf9, Flag, His) is 312 a.a.,
The NLRP6 protein serves as the central sensor of the NLRP6 inflammasome, driving inflammasome activation in response to various pathogen-related signals. It recognizes specific pathogen- and damage-associated signals, such as lipoteichoic acid (LTA) and double-stranded RNA (dsRNA), initiating liquid-liquid phase separation (LLPS) to form complexes. NLRP6 Protein, Human (Sf9) is the recombinant human-derived NLRP6 protein, expressed by Sf9 insect cells , with tag free. The total length of NLRP6 Protein, Human (Sf9) is 892 a.a., .
The NLRP6 protein serves as the central sensor of the NLRP6 inflammasome, driving inflammasome activation in response to various pathogen-related signals. It recognizes specific pathogen- and damage-associated signals, such as lipoteichoic acid (LTA) and double-stranded RNA (dsRNA), initiating liquid-liquid phase separation (LLPS) to form complexes. NLRP6 Protein, Human (Sf9, His, MBP) is the recombinant human-derived NLRP6, expressed by Sf9 insect cells , with MBP, His labeled tag. ,
AngiotensinIIhuman- 13C6, 15N TFA (Ang II- 13C6, 15N TFA) is 13C- and 15N-labeled AngiotensinIIhuman (TFA) (HY-13948B). AngiotensinIIhuman (AngiotensinII) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. AngiotensinIIhuman TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between AngiotensinII and the G-protein-coupled receptors (GPCRs) AngiotensinII type 1 receptor (AT1R) and AngiotensinII type 2 receptor (AT2R). AngiotensinIIhuman TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions .
Angiotensin I-13C6,15N (human, mouse, rat) TFA is 13C and 15N labeled Angiotensin I (human, mouse, rat) TFA. Angiotensin I-13C6,15N (human, mouse, rat) TFA is a precursor of angiotensinII and is cleaved into angiotensinII by angiotensin converting enzyme (ACE) .
Eprosartan-d3 is the deuterium labeled Eprosartan. Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensinII receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensinII receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively [1].
Eprosartan-d6 is deuterated labeled Eprosartan (HY-117743). Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensinII receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensinII receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .
Losartan carboxylic acid-d4 (hydrochloride) is deuterium labeled Losartan Carboxylic Acid. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensinII receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensinII-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure[1][2][3][4].
ACE Antibody is an unconjugated, approximately 150 kDa, rabbit-derived, anti-ACE monoclonal antibody. ACE Antibody can be used for: WB,IHC-P,FC expriments in human, mouse background without labeling.
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